Lipids are a broad group of naturally-occurring molecules which includes fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The main biological functions of lipids include energy storage, as structural components of cell membranes, and as important signaling molecules.
Few questions have captivated humankind more than the origin of life on Earth. How did the first living cells come to exist? How did these early protocells develop the structural membranes necessary for cells to thrive and assemble into complex organisms?
Findings indicate ovarian cancer disrupts CD8+ T cell metabolism through FABP5 and TAGLN2, suggesting new therapeutic targets for enhancing immune function.
Glycans are sugar chains that bind to cells via proteins or lipids, altering their chemical properties
Humans can do plenty, but plants have an ability we don't: they make energy straight from sunlight, a superpower called photosynthesis. Yet new research shows that scientists are closing that gap.
Humans aren't the only ones who grow forgetful as they age -; fruit flies do, too. But because fruit flies have a lifespan of only about two months, they can be a useful model for understanding the cognitive decline that comes with aging.
Researchers at Weill Cornell Medicine have shown that ovarian cancers disable immune cells and prevent them from attacking by cutting off the energy source that T cells rely on.
A scientific investigation led by researchers at HKUST has uncovered promising avenues for treating injuries to the central nervous system, with findings published in Proceedings of the National Academy of Sciences.
According to a study conducted by researchers at the Van Andel Institute, preventing cancer cells from obtaining fat may improve the efficacy of a particular cancer treatment.
Programmed cell death protects the body against cancer and other diseases. A team of researchers led by Professor Alexander Bartelt from the Institute for Cardiovascular Prevention (IPEK) has decoded a new mechanism by which oxidative stress influences cell death.
Acute kidney injury (AKI) is associated with a poor prognosis, and no effective treatment has been established to date. Understanding the mechanisms that prevent the progression of AKI is crucial. In AKI, immune cells known as macrophages produce lipid mediators (LMs), which are lipids with significant physiological activity and play a pivotal role in promoting and suppressing inflammation. Thus, elucidating their function is of paramount importance.
Sexual reproduction, a common mode of reproduction among numerous species, involves gametogenesis in which offspring are produced through fertilization, conjugation, or mating. In plants and animals, eggs and sperm differentiate from germ cells to form gametes.
A new study by Rice University researchers led by Jason Hafner could open new pathways for understanding how cholesterol influences cell membranes and their receptors, paving the way for future research on diseases linked to membrane organization.
Virginia Tech researchers have learned how bacteria manipulate molecules to infect the host organism.
Cells are highly controlled spaces that rely on every protein being in the right place. Many diseases, including cancers and neurodegenerative disorders, are associated with misplaced proteins. In some cancers, for instance, a protein that normally stands watch over DNA replicating in the nucleus is sent far from the DNA it is meant to monitor, allowing cancers to grow.
In a recent study published in Nature Communications, researchers utilized a comprehensive multi-omics approach, integrating genomic, proteomic, and metabolomic data from a diverse cohort, to uncover detailed molecular interactions and identify distinct diabetes subgroups.
Modified nucleotides like m5C in saRNA enhance vaccine efficacy, stability, and reduce inflammation, offering a promising approach for SARS-CoV-2 protection.
Cancer cells seldom start off stealthy. Quite to the contrary, they announce their presence to the immune system by planting chemical red flags right on their membranes.
Researchers at the Institute for Integrated Cell-Material Sciences (WPI-iCeMS) at Kyoto University have discovered new information regarding how cells control the distribution of lipids in their cell membrane.
A study by the team of Prof. Kodi Ravichandran (VIB-UGent Center for Inflammation Research) and colleagues found that pyroptosis, a form of programmed cell death traditionally thought to be purely inflammatory, also plays a crucial role in promoting healing and tissue repair.
Scientists are working to create quicker, more quantitative, and more publicly available methods of seeing biomolecules in living cells to speed up biotechnology discoveries, such as the production of lifesaving drugs.
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