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Macrophage Inflammation may Contribute to LSD Symptoms

Researchers at The Hospital for Sick Children (SickKids) have found that inflammation in an immune cell may be responsible in part for some severe symptoms in a group of rare genetic conditions called lysosomal storage diseases (LSDs).

15 Jul 2024

CRISPR Screening Reveals Peptide in Human RNA Regulating Inflammation

UC Santa Cruz researchers have discovered a peptide in human RNA that regulates inflammation and may provide a new path for treating diseases such as arthritis and lupus.

27 May 2024

Unlocking Glucose-Driven Mechanisms of Immunosuppression in Glioblastoma

The Wistar Institute assistant professor Filippo Veglia, Ph.D., and team, have discovered a key mechanism of how glioblastoma -; a serious and often fatal brain cancer -; suppresses the immune system so that the tumor can grow unimpeded by the body's defenses.

6 May 2024

Harmless Particles Enhance Immune Response, Study Finds

Our lungs are bombarded by all manner of different particles every single day. Whilst some are perfectly safe for us, others-;known as pathogens-;have the potential to make us ill.

29 Apr 2024

Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

16 Jan 2024

STING-seq Discovers Causal Variants and Genetic Mechanisms for Blood Cell Traits

A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the 98% of the genome that does not encode proteins.

5 May 2023

Myeloid cells contribute to a long-lived HIV reservoir, study shows

A subset of white blood cells, known as myeloid cells, can harbor HIV in people who have been virally suppressed for years on antiretroviral therapy, according to findings from a small study supported by the National Institutes of Health.

28 Mar 2023

Monocytes harbor stable HIV DNA capable of infecting neighboring cells

To develop treatments that may one day entirely rid the body of HIV infection, scientists have long sought to identify all of the places that the virus can hide its genetic code.

28 Mar 2023

Study discovers the ability of certain blood immune cells to proliferate

The ability of a cell to divide, to proliferate, is essential for life and gives rise to the formation of complex organisms from a single cell.

20 Mar 2023

Study highlights key role of group 2 innate lymphoid cells in shaping the alveolar niche

A study conducted by researchers at the University of Liège on group 2 innate lymphoid cells (or ILC2s) shows that the functional reprogramming of these cells following their exposure to viruses allows our body to react differently to exposure to certain respiratory allergens.

27 Feb 2023

Macrophages show altered inflammatory, metabolic expression months after mild COVID-19

There is a lack of understanding as to why some people suffer from long-lasting symptoms after COVID-19 infection.

15 Mar 2022

Study shows how the immune system effectively combats coronavirus to prevent pneumonia

Most people’s immune responses are powerful enough to prevent the SARS-CoV-2 virus from spreading throughout the body that they are immune to pneumonia.

11 Mar 2022

Cell-analysis method could pave the way for new strategies to fight tuberculosis

A new method that analyzes how individual immune cells react to the bacteria that cause tuberculosis could pave the way for new vaccine strategies against this deadly disease, and provide insights into fighting other infectious diseases around the world.

23 Jul 2021

Researchers discover protein that may trigger lung scarring

Systemic sclerosis is an autoimmune disease associated with inflammation and fibrosis, or scarring, that affects organs including the skin, heart, kidney and lungs.

18 Dec 2020

CAR T cell therapy can predict treatment outcomes in patients with large B-cell lymphoma

Scientists have identified cellular and molecular features of anti-CD19 CAR T cell infusion products that are correlated with large B-cell lymphoma (LBCL).

6 Oct 2020

Study shows immune cells contribute to brain infection

A new study shows how the immune system has a damaging effect on a severe brain condition, which is most commonly caused by the cold sore virus.

17 Sep 2020

Blood Cells Could Serve As A 'Thermometer' To Detect Breast Cancer

Immune system cells in the blood of breast cancer patients undergo alterations early in the disease course, according to a study.

18 May 2020

New type of antigen-presenting immune cell discovered

With a discovery that could rewrite the immunology textbooks, an international group of scientists, including the teams of Bart Lambrecht, Martin Guilliams, Hamida Hammad, and Charlotte Scott (all from the VIB-UGent Center for Inflammation Research) identified a new type of antigen-presenting immune cell.

12 May 2020