Neurodegenerative Disorder News and Research

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Oligodendrocytes as Producers of Amyloid Beta in Alzheimer's Disease

Oligodendrocytes are an important source of amyloid beta (Aβ) and play a key role in promoting neuronal dysfunction in Alzheimer's disease (AD), according to a study published July 23, 2024 in the open-access journal PLOS Biology by Rikesh Rajani and Marc Aurel Busche from the UK Dementia Research Institute at University College London, and colleagues.

24 Jul 2024

Novel protein biomarker panel can detect Parkinson's disease in early stages using blood samples

A team of researchers used multiplexed mass spectrometry data and a machine learning model to identify biomarkers that can predict Parkinson’s disease.

27 Jun 2024

Innovative ssREAD Database Provides Rich Alzheimer's Disease RNA-Seq Resources for Researchers

The Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease, or ssREAD.

12 Jun 2024

CSHL Researchers Unravel Why Some Splicing-Based Drugs Tend to Work Better Than Others

Spinal muscular atrophy, or SMA, is the leading genetic cause of infant death. Less than a decade ago, Cold Spring Harbor Laboratory (CSHL) Professor Adrian Krainer showed this brutal disease can be treated by tweaking a process called RNA splicing.

6 Mar 2024

How the Disturbed Recycling Chain of Endoplasmic Reticulum Causes Neurodegenerative Diseases

Our cells are crisscrossed by a system of membrane tubes and pockets called the endoplasmic reticulum (ER). It is crucial for the production of biomolecules and is continuously built up and degraded.

29 May 2023

Discovery of Shanghai APP Mutation Offers New Avenues for Treatment of Alzheimer's Disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting tens of millions of people worldwide, and it is the most common cause of dementia.

15 May 2023

Researchers get funding to develop a vaccine against ALS disease

DZNE and Intravacc B.V., have received a grant from the European Union of € 2.5 million to further create a prototype ALS vaccine.

8 Jul 2022

Little-known protein may play a role in frontotemporal lobar degeneration

Scientists have known for years that amyloid fibrils -; fibrous, ropelike structures formed by closely linked protein molecules -; are present in the brains of patients with Alzheimer's and Parkinson's diseases and likely play a role in the progression of these disorders.

21 Apr 2022

Study discovers common genetic factors between depression and Alzheimer’s disease

Recent research discovered common genetic factors between depression and AD.

18 Feb 2022

First molecular images of enzyme may help solve the mystery cause of hereditary neurodegenerative diseases

WEHI researchers have produced the first molecular images of an enzyme that controls proteins to signal and communicate with each other in human cells.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 13 Jan 2022

Research reveals involvement of secretory granules in Parkinson’s disease

Recent research states that the number of secretory granules (SGs) in tyrosine hydroxylase-positive neurons and the marker proteins secretogranin III substantially lowered in the substantia nigra and striatum regions of mice exposed to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine.

13 Oct 2021

Study discloses neuroprotective properties of aromatic turmerone and its derivatives

Scientists discovered that aromatic turmerone and its derivatives have a direct effect on the dopaminergic nerves.

16 Jul 2021

Mass spectrometry: Important analytical tool to understand Huntington’s disease proteome

Mass spectrometry has emerged as an important analytical tool for gaining a better understanding of mechanisms underlying Huntington's disease (HD), alongside the increased availability of cell and animal models of the disease.

14 Jul 2021

Children with rare genetic disorder experience dramatic improvements in a gene therapy trial

Children with a devastating genetic disorder characterized by severe motor disability and developmental delay have experienced sometimes dramatic improvements in a gene therapy trial launched at UCSF Benioff Children's Hospitals.

13 Jul 2021

Study finds an amyloid link between melanoma and Parkinson’s disease

Parkinson’s disease is a neurodegenerative disorder and melanoma is a type of skin cancer but on the surface, these disorders do not seem to have much in common.

8 Apr 2021

Study reveals molecular profiles of Parkinson's disease

The second most common neurodegenerative disorder is Parkinson’s disease, but despite this, not much is known about the causes of this condition.

17 Mar 2021

Two new Alzheimer’s genes discovered

AZoLifeSciences speaks to researchers from Tianjin Medical University about their latest research that led to the discovery of two new genes that are linked to Alzheimer's disease.

From Tianjin Medical University 1 Mar 2021

Scientists identify mystery protein that explains the origins of Parkinson's Disease

Researchers have made a “vital step” toward inferring the origins of Parkinson’s disease—a neurological condition that is rapidly growing in the world.

11 Feb 2021

New fluorescent probe to detect damaged mitochondria could help treat neurodegenerative disorders

Scientists have developed a new, multipurpose probe that is capable of detecting the programmed destruction of faulty mitochondria with pinpoint precision.

17 Aug 2020

Identifying a new genetic cause of inherited neuropathy

Inherited mutations in a gene that keeps nerve cells intact were shown, for the first time, to be a driver of neuropathy known as Charcot-Marie-Tooth disease.

4 Aug 2020