Nucleotide News and Research

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Wheat's Pathogen Defense Strengthened by Tandem Kinase Proteins

Wheat is grown over more land area than any other food crop. Among pathogen-driven threats to wheat, fungi top the list, causing billions of dollars of losses each year and posing a serious challenge to food security worldwide.

3 Apr 2025

How Does DNA Unwind? Study Explores Helicase Mechanisms In DNA Replication

This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights into viral replication mechanisms.

28 Mar 2025

New Discovery Sheds Light on C. Diff's Survival Mechanism in the Gut

The pathogen C. diff - the most common cause of health care-associated infectious diarrhea - can use a compound that kills the human gut's resident microbes to survive and grow, giving it a competitive advantage in the infected gut.

26 Mar 2025

UV Light Reshapes 3D Genome Structure, Altering DNA Repair and Gene Activity

Research shows UV radiation modifies 3D genome structure, affecting DNA damage response and gene activity, offering insights for cancer prevention strategies.

24 Mar 2025

Cryo-EM Reveals 3D Structure of Nipah Virus RNA Polymerase

The replication of the Nipah virus's genetic material in infected cells has been demonstrated for the first time by researchers from the Max Planck Institute (MPI) for Multidisciplinary Sciences and the University Medical Center Göttingen (UMG). In humans, the virus can cause fatal encephalitis.

11 Mar 2025

RNA Splicing Errors May Hold the Key to Beating Gliomas Using Immunotherapy

Identifying splicing-related neoantigens in gliomas opens new avenues for immunotherapy, enhancing treatment strategies for this challenging brain tumor.

26 Feb 2025

Random Versions of Human Genomes Created to Unlock Disease Mechanisms

The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought.

3 Feb 2025

Human Cell Lines Reveal Genome's Tolerance to Structural Variation

The most advanced engineering of human cell lines to date has been accomplished by scientists, demonstrating that genomes are more robust against significant structural changes than previously understood.

31 Jan 2025

High-Throughput Method Reveals the Effects of Active Substances on Cellular Metabolism

Researchers at the University of Basel are able to test in parallel the effects of over 1500 active substances on cell metabolism.

29 Jan 2025

Is it possible to predict a pathogen’s next move? Novel tool for detecting pathogen fitness says yes!

Phylowave reveals evolutionary dynamics in pathogens, identifying fitness-linked lineages and mutations, essential for effective public health interventions.

13 Jan 2025

Rewriting History: Advanced Genetic Analysis Uncovers Ancient Ancestry Shifts in Europe

High-resolution analysis of ancient genomes reveals key Scandinavian ancestry movements in early medieval Europe, highlighting complex genetic interactions.

9 Jan 2025

Genetic Discovery Offers Potential for Higher Crop Yields and Biofuel Production

A team of scientists with two Department of Energy Bioenergy Research Centers -; the Center for Bioenergy Innovation, or CBI, at Oak Ridge National Laboratory and the Center for Advanced Bioenergy and Bioproducts Innovation, or CABBI, at the University of Illinois Urbana-Champaign -; identified a gene in a poplar tree that enhances photosynthesis and can boost tree height by about 30% in the field and by as much as 200% in the greenhouse.

6 Jan 2025

PlantRNA-FM: Bridging the Gap Between RNA Structure and Function

With PlantRNA-FM, researchers can systematically analyze plant RNA, uncovering functional motifs that play key roles in gene expression and stress responses.

23 Dec 2024

Researchers Uncover Lamin A's Role in DNA Repair and Premature Aging Disease

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have discovered how a protein called lamin A helps repair the protective barrier around a cell's DNA.

16 Dec 2024

New Class of CRISPR-Cas Enzymes for Precise Genome Editing

Recent research published in the journal “Science Bulletin” detailed the creation of a tool called ChCas12b that can accurately edit genomes and identify single-base mutations.

9 Dec 2024

AI Tool for Accelerating Biological Discovery

Brian Hie leads the Laboratory of Evolutionary Design at Stanford, focusing on the intersection of artificial intelligence and biology.

5 Dec 2024

Study Links MICOS10 Gene Defect to Mitochondrial DNA Depletion Syndrome

Mitochondrial DNA depletion syndrome (MTDPS) is a rare genetic disorder characterized by a marked decrease in mitochondrial DNA (mtDNA).

27 Nov 2024

Novel Genetic Variant Associated with Severe Mitochondrial Dysfunction

The rare hereditary condition known as mitochondrial DNA depletion syndrome (MTDPS) is typified by a significant reduction in mitochondrial DNA (mtDNA).

26 Nov 2024

Discovery of Large Tandem Duplications Opens New Avenues for Cancer Treatment

Cancer researchers at the University of Chicago and the University of California, San Francisco (UCSF) have discovered that mutations in certain genes can lead to the accumulation of DNA errors, resulting in a specific type of genetic change known as large tandem duplications (TDs) that can arise from the collision of two critical cellular processes: transcription and DNA replication.

21 Nov 2024

Sylph: A Fast and Accurate Tool for Species-Level Metagenome Profiling

Sylph's innovative approach to metagenome profiling delivers high accuracy and efficiency, advancing research in microbial diversity and disease associations.

21 Nov 2024