Nucleotides News and Research

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Sylph: A Fast and Accurate Tool for Species-Level Metagenome Profiling

Sylph's innovative approach to metagenome profiling delivers high accuracy and efficiency, advancing research in microbial diversity and disease associations.

21 Nov 2024

Innovative Biocatalysis Method Promises Faster, Greener Drug Manufacturing

Researchers have found a new way to use biocatalysis to improve the production of critical raw materials required for essential drugs, making the process quicker, more efficient, and environmentally friendly.

9 Nov 2024

Unveiling the Molecular Mechanisms of CRISPR-Cas10's Cellular Shutdown

CRISPR-Cas9 can elegantly and precisely cut away any desired region of DNA and has long been compared to a type of genetic scissors.

29 Oct 2024

Peptide Inhibitor Could Revolutionize mRNA-Based Therapies

The new hope in the fight against diseases that cannot be cured is mRNA-based vaccinations and treatments.

17 Oct 2024

AI Uncovers Over 160000 New RNA Virus Species

Artificial intelligence (AI) has been used to reveal details of a diverse and fundamental branch of life living right under our feet and in every corner of the globe.

10 Oct 2024

Modified Nucleotides Boost saRNA Vaccine Efficacy and Protection Against SARS-CoV-2

Modified nucleotides like m5C in saRNA enhance vaccine efficacy, stability, and reduce inflammation, offering a promising approach for SARS-CoV-2 protection.

18 Sep 2024

A Novel Method for Incorporating Non-Canonical Amino Acids into Proteins

Every basic biology lesson teaches that proteins are made up of combinations of 20 distinct amino acids, which are ordered in various patterns similar to words.

12 Sep 2024

CDCA7's Role in DNA Methylation Maintenance Revealed in Recent Study

DNA methylation is a process in which a methyl group is attached to the cytosine base of the DNA molecule, and a major way that DNA is epigenetically marked. Epigenetic modifications can act as on-off switches to regulate gene expression and help generate diverse cell types without changing the underlying DNA sequence. It is how the body ensures that brain-related genes don't get turned on in heart cells, for example.

28 Aug 2024

DNA Sequence Variants Drive Link Between Methylation and Gene Expression

The relationship between DNA methylation and gene expression is driven by sequence variants, according to a recent study conducted by researchers at deCODE Genetics, an Amgen subsidiary.

25 Jul 2024

Decoding Dengue: The Use of Less Efficient Codons for Viral Advantage

Mosquito-borne viral infections once confined to tropical regions are spreading. Dengue virus infects up to 400 million people worldwide each year according to World Health Organization estimates, and no available treatments exist for this disease.

24 Jul 2024

Harnessing Enzymes for Making RNA Therapeutics

While the COVID-19 vaccines introduced many people to RNA-based medicines, RNA oligonucleotides have already been on the market for years to treat diseases like Duchenne Muscular Dystrophy and amyloidosis.

15 Jul 2024

New Gene-Editing Tool Offers More Precision and Flexibility

Researchers at the University of Sydney have created a gene-editing instrument that is more precise and adaptable than the industry standard CRISPR, which has transformed genetic engineering in biotechnology, agriculture, and medicine.

24 Jun 2024

MIT Researchers Develop Amber-Like Polymer for Room-Temperature DNA Storage

In the movie "Jurassic Park," scientists extracted DNA that had been preserved in amber for millions of years, and used it to create a population of long-extinct dinosaurs.

14 Jun 2024

Deciphering the Significance of m6A RNA Modification in HIV-1 Genome

A chemical modification in the HIV-1 RNA genome whose function has been a matter of scientific debate is now confirmed to be key to the virus's ability to survive and thrive after infecting host cells, a new study has found.

13 Apr 2024

Study Reveals Structure of Two Nucleic Acid-Degrading Enzymes

When nucleic acids like DNA or RNA build up in a cell's cytoplasm, it sets off an alarm call for the immune system.

3 Apr 2024

Microsatellites' Stability Through Deep Time: Insights from Adélie Penguin Genomes

Microsatellites are valuable tools for studying inheritance, genetic diversity, and population dynamics across a wide range of organisms including bacteria, plants, animals, and fungi. These

2 Apr 2024

Protein Fragments Uncover New Extremophiles, Aiding Alien Life Search

Microorganisms with perfect adaptations can survive in harsh settings, such as deep-sea tunnels and mountain peaks.

18 Mar 2024

Study Reveals Gut Microbiome's Influence on Premature Aging in Chronic HIV Patients

The Wistar Institute's associate professor Mohamed Abdel-Mohsen, Ph.D., has demonstrated, with his lab and collaborators, a connection between viral damage to the gut and premature biological aging.

22 Feb 2024

Discovery of a Subset of Human Short Introns That Are Spliced Out by a Novel Mechanism

The well-known essential pre-mRNA splicing factor U2AF heterodimer (U2AF2–U2AF1) has been considered to mediate early splicing reaction in all introns of different lengths.

15 Feb 2024