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New Discovery Sheds Light on C. Diff's Survival Mechanism in the Gut

The pathogen C. diff - the most common cause of health care-associated infectious diarrhea - can use a compound that kills the human gut's resident microbes to survive and grow, giving it a competitive advantage in the infected gut.

26 Mar 2025

Cryo-EM Reveals 3D Structure of Nipah Virus RNA Polymerase

The replication of the Nipah virus's genetic material in infected cells has been demonstrated for the first time by researchers from the Max Planck Institute (MPI) for Multidisciplinary Sciences and the University Medical Center Göttingen (UMG). In humans, the virus can cause fatal encephalitis.

11 Mar 2025

Understanding the World Beyond DNA and Genes

Curled up inside every single one of the trillions of cells in the human body is six feet of DNA, spooled tightly and carrying the genetic instructions that govern so much of who a person becomes.

17 Feb 2025

Genetic Editing Reveals Key Functions of Bean Plant Genes in Nitrogen Fixation

Beans are a key food at the dietary level, boasting high nutritional value and constituting the most directly consumed legume.

8 Feb 2025

Random Versions of Human Genomes Created to Unlock Disease Mechanisms

The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought.

3 Feb 2025

Human Cell Lines Reveal Genome's Tolerance to Structural Variation

The most advanced engineering of human cell lines to date has been accomplished by scientists, demonstrating that genomes are more robust against significant structural changes than previously understood.

31 Jan 2025

High-Throughput Method Reveals the Effects of Active Substances on Cellular Metabolism

Researchers at the University of Basel are able to test in parallel the effects of over 1500 active substances on cell metabolism.

29 Jan 2025

Discovery of ALAS1's Secret Role Could Boost Cancer Therapy Development

In everyday life, when things turn out the opposite of what you expect, it's usually cause for frustration. In science, it's often the starting point for discovery.

23 Dec 2024

PlantRNA-FM: Bridging the Gap Between RNA Structure and Function

With PlantRNA-FM, researchers can systematically analyze plant RNA, uncovering functional motifs that play key roles in gene expression and stress responses.

23 Dec 2024

New Look at the Last Universal Common Ancestor

Revising genetic code evolution, this research uncovers early amino acid recruitment patterns and sulfur's significance for understanding extraterrestrial life.

13 Dec 2024

AI Tool for Accelerating Biological Discovery

Brian Hie leads the Laboratory of Evolutionary Design at Stanford, focusing on the intersection of artificial intelligence and biology.

5 Dec 2024

Amborella trichopoda sheds light on ZW sex chromosome evolution in angiosperm plants

A recent study characterizes the ZW sex chromosomes in Amborella trichopoda, revealing insights into sex determination and early evolutionary dynamics in plants.

4 Dec 2024

Sylph: A Fast and Accurate Tool for Species-Level Metagenome Profiling

Sylph's innovative approach to metagenome profiling delivers high accuracy and efficiency, advancing research in microbial diversity and disease associations.

21 Nov 2024

Innovative Biocatalysis Method Promises Faster, Greener Drug Manufacturing

Researchers have found a new way to use biocatalysis to improve the production of critical raw materials required for essential drugs, making the process quicker, more efficient, and environmentally friendly.

9 Nov 2024

Unveiling the Molecular Mechanisms of CRISPR-Cas10's Cellular Shutdown

CRISPR-Cas9 can elegantly and precisely cut away any desired region of DNA and has long been compared to a type of genetic scissors.

29 Oct 2024

Peptide Inhibitor Could Revolutionize mRNA-Based Therapies

The new hope in the fight against diseases that cannot be cured is mRNA-based vaccinations and treatments.

17 Oct 2024

AI Uncovers Over 160000 New RNA Virus Species

Artificial intelligence (AI) has been used to reveal details of a diverse and fundamental branch of life living right under our feet and in every corner of the globe.

10 Oct 2024

Modified Nucleotides Boost saRNA Vaccine Efficacy and Protection Against SARS-CoV-2

Modified nucleotides like m5C in saRNA enhance vaccine efficacy, stability, and reduce inflammation, offering a promising approach for SARS-CoV-2 protection.

18 Sep 2024

A Novel Method for Incorporating Non-Canonical Amino Acids into Proteins

Every basic biology lesson teaches that proteins are made up of combinations of 20 distinct amino acids, which are ordered in various patterns similar to words.

12 Sep 2024

CDCA7's Role in DNA Methylation Maintenance Revealed in Recent Study

DNA methylation is a process in which a methyl group is attached to the cytosine base of the DNA molecule, and a major way that DNA is epigenetically marked. Epigenetic modifications can act as on-off switches to regulate gene expression and help generate diverse cell types without changing the underlying DNA sequence. It is how the body ensures that brain-related genes don't get turned on in heart cells, for example.

28 Aug 2024