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Bridge RNA: The Revolutionary Tool in Genetic Recombination

In a leap forward for genetic engineering, a team of researchers from the Arc Institute have discovered the bridge recombinase mechanism, a precise and powerful tool to recombine and rearrange DNA in a programmable way.

27 Jun 2024

Arrowhead's Plozasiran Reduces Triglyceride Rich Lipoproteins in Patients with Mixed Hyperlipidemia

Arrowhead Pharmaceuticals, Inc. today announced results from the Phase 2b double blind, randomized MUIR study of investigational plozasiran (formerly ARO-APOC3) in patients with mixed hyperlipidemia.

3 Jun 2024

Breakthrough RNA-Based Vaccine Strategy Offers Universal Protection

Scientists at UC Riverside have demonstrated a new, RNA-based vaccine strategy that is effective against any strain of a virus and can be used safely even by babies or the immunocompromised.

16 Apr 2024

Study Identifies Risk Genes and Regulatory Variants for Colorectal Cancer by Integrating Multi-Omics Data

This study was led by Prof. Xiao-Ping Miao' team from the School of Public Health, Wuhan University, in collaboration with Prof. Shaokai Zhang from the Henan Cancer Hospital.

2 Nov 2023

New Toxin Found to Enhance Pathogen Infection and Disease Spread in Wheat

Although wheat was among the first domesticated food crops, it remains a global dietary staple several millennia later.

14 Jul 2023

Describing the molecular basis behind the ultrafast contraction of Spirostomum

Antonie van Leeuwenhoek stated that a single-celled eukaryote (Vorticella) and its appealing ultrafast cell contraction was the first set of discoveries. This was told in his famous letter to the Royal Society dated October 9th, 1676.

23 Feb 2023

Orbit Discovery and SanegeneBio collaborate to identify targeting peptides for RNAi drugs

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From Orbit Discovery 5 Jan 2023

Using in vivo self-assembled siRNA as part of combination therapy for ulcerative colitis

There is still a large unmet medical need for the treatment of ulcerative colitis, despite recent improvements in the understanding of the pathogenic mechanisms of ulcerative colitis.

30 Sep 2022

Study reveals how RNAi workhorse protein optimizes to keep protein synthesis on track

Proteins are made in cells in the same way as they are made in factories. However, making too much at the wrong moment may lead to illnesses like cancer, so they use RNA interference (RNAi) to regulate production.

1 Jun 2022

Mapping the genome of Eurasian spruce bark beetle reveals new insights

Researchers have successfully mapped the entire genome of the Eurasian spruce bark beetle. The breakthrough paves the way for new research into bark beetles and better prospects for effective pest control of a species that can destroy more than 100 million cubic meters of spruce forest during a single year in Europe and Asia.

30 Sep 2021

Newly identified protein regulates the flow of materials in the Drosophila ovary

According to a research work performed by Northwestern Medicine and published in the Current Biology journal, a protein helps guide the flow of materials in the ovary of Drosophila fruit flies during the formation of egg cells.

17 Jun 2021

Genetic and molecular mechanisms make chemotherapy drug work for some cancer patients

The chemotherapy drug decitabine is commonly used to treat patients with blood cancers, but its response rate is somewhat low. Researchers have now identified why this is the case, opening the door to more personalized cancer therapies for those with these types of cancers, and perhaps further afield.

25 May 2021

Study could help develop peptide siRNA carrier for human oral cancer

MUSC Hollings Cancer Center researchers are exploring the use of peptide carriers for the delivery of small RNA drugs as a novel treatment for cancer. The team's recent work, published online March 19 in the Molecular Therapy - Nucleic Acids journal, lays the foundation for developing a clinically relevant peptide carrier RNAi-based drug treatment strategy for human oral cancer.

25 May 2021

Researchers identify promising treatments for late-onset Alzheimer’s disease

Scientists from The Mount Sinai Hospital and the National Center for Geriatrics and Gerontology based in Japan have recently discovered novel molecular mechanisms that drive late-onset Alzheimer’s disease (LOAD).

25 Nov 2020

Movement of small RNAs underlies mobile RNA interference

Biologists have known for some time that RNA interference can silence genes in far-off cells. They suspected that a messenger substance “transmits” RNA interference.

29 Jul 2020

New startup launched to overcome the challenge of delivering next-generation therapeutics

Harvard University's Office of Technology Development (OTD) and the Harvard T.H. Chan School of Public Health today announced the launch of Vesigen Therapeutics, a startup company that aims to overcome the challenge of delivering next-generation therapeutics, such as gene-editing complexes, RNA molecules, and other large proteins, to intracellular targets in specific tissues of interest.

23 Jul 2020

UCL scientists discover genes responsible for maintaining healthy hearing

Scientists at UCL have discovered sets of regulatory genes, which are responsible for maintaining healthy hearing. The finding, made in fruit flies, could potentially lead to treatments for age-related hearing loss (ARHL) in humans.

From University College London 3 Jun 2020

Entos and Precision NanoSystems to develop vaccines and therapeutics using NanoAssemblr GMP System

Entos Pharmaceuticals, a healthcare biotechnology company developing next generation nucleic acid medicines with their Fusogenix delivery platform announced today a partnership with Precision NanoSystems, Inc., (PNI), a global leader in enabling transformative nanomedicines, to produce clinical grade vaccines and therapeutics using PNI's NanoAssemblr GMP System.

7 May 2020