Shigella News and Research

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New Weapon in the Fight Against Antimicrobial Resistance

According to the Centers for Disease Control and Prevention, waterborne illnesses cost the healthcare system more than $3 billion a year and impact more than seven million Americans. However, not everyone is affected in the same way.

7 Nov 2024

Unveiling the Molecular Mechanisms of Shigella flexneri Infection

Virginia Tech researchers have learned how bacteria manipulate molecules to infect the host organism.

23 Sep 2024

UConn Health scientists explain why Shigella bacteria can infect humans but not mice

Shigella bacteria can infect humans but not mice. In the March 29 issue of Nature, a team from UConn Health explains why. Their findings may explain the multifariousness of a key weapon of our immune system.

31 Mar 2023

Using viruses to fight antibiotic-resistant "superbugs"

The Centers for Disease Control and Prevention warns that the increase in cases of the drug-resistant bacterial infection Shigella could be a predictor of what's to come for other bacteria.

22 Mar 2023

Genomic study helps retrace origin and spread of Shigellosis outbreak in Seattle

A genomic study of a sustained, multidrug-resistant Shigellosis outbreak in Seattle enabled scientists to retrace its origin and spread.

1 Feb 2023

New genomic study suggests protein-based antigens provide more stable vaccine targets for Shigella

New genomics research conducted by the University of Liverpool will aid in the development and implementation of vaccinations against Shigella.

2 Feb 2022

Study identifies novel function for existing protein

Researchers recently identified a new role of the protein tBID, which was to date linked to the regulatory role in cancer and cell death. But tBID also directly mediates apoptosis (controlled cell death).

23 Dec 2021

New details about Shigella's translocon may help develop effective strategy to block infection

Shigella, a bacterial pathogen that causes dysentery and is the leading cause of childhood diarrheal diseases, inserts a pore called a translocon into an infected person's intestinal cells and then injects bacterial proteins into the cells.

24 Nov 2021

Novel molecular survival strategy of Shigella bacterium uncovered

Enteric pathogens, such as the bacterium Shigella, can cause severe intestinal disease with bloody diarrhea. In a new study, researchers from Tokyo Medical and Dental University (TMDU) discovered a novel molecular survival strategy by which Shigella is able to cause damage to the intestines despite two elaborate protective mechanisms used by host cells.

19 Aug 2020

Study shows how vulnerable cells armor themselves against infection

Cells in some of the body's most vulnerable entry routes to bacterial infection buffer themselves when the immune system detects danger by reorganizing the cholesterol on their surfaces, a new study led by UTSW scientists suggests.

16 Apr 2020

Bacterial acid tolerance system shown to confer growth capability to enteric bacteria

The potential to proliferate under acidic conditions is crucial for bacteria. Escherichia coli, Salmonella, and other such enteric bacteria have the ability to colonize and cause disease in the intestinal tract of the host. Yet, they must fight against acidic environments in the entire process of host invasion.

23 Mar 2020