Transcriptomics News and Research

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Understanding Marine Worms’ Unique Ability to Regenerate Lost Body Parts

Many living organisms are able to regenerate damaged or lost tissue, but why some are particularly good at this and others are not is not fully understood.

19 Nov 2024

MIT Engineers Develop Model to Decode Complex Biological Systems

Over the past two decades, new technologies have helped scientists generate a vast amount of biological data. Large-scale experiments in genomics, transcriptomics, proteomics, and cytometry can produce enormous quantities of data from a given cellular or multicellular system.

6 Nov 2024

Unraveling the Spatial Complexity of Gene Expression with Seq-Scope

A new method, developed by University of Michigan researchers, creates images that are worth many gigabytes of data, which could revolutionize the way biologists study gene expression. Seq-Scope, developed by Jun Hee Lee, Ph.D., Hyun Min Kang, Ph.D., and their colleagues, was first described in Cell in 2021 as the first method to analyze gene expression at sub micrometer-scale spatial resolution.

1 Nov 2024

Innovative Genomic Technology Uncovers Mechanisms of Marjolin's Ulcer

Researchers utilized specialized genomic technology at the University of Calgary to enhance our understanding of Marjolin's ulcer (MU), a rare, highly aggressive skin cancer that affects chronic wounds that can often arise from established scars like those caused by severe burns.

29 Oct 2024

A Novel Method for Improving Spatial Resolution in Transcriptomic Analysis

Existing spatial transcriptomics methods frequently lack the precision required to examine single cells in tissue samples, hindering their ability to reveal intricate biological information.

21 Oct 2024

Proteomics Reveals Age-Related Changes in Mouse Bone Formation

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 19 on October 12, 2024, entitled, "A proteomics approach to study mouse long bones: examining baseline differences and mechanical loading-induced bone formation in young-adult and old mice."

16 Oct 2024

Human Skin Map Gives ‘Recipe’ to Build Skin and Could Help Prevent Scarring

For the first time, researchers have created a single cell atlas of prenatal human skin to understand how skin forms, and what goes wrong in disease.

From Wellcome Sanger Institute 14 Oct 2024

New Tool START Enables Precision Mapping of Neuronal Connectivity

Scientists at the Salk Institute are unveiling a new brain-mapping neurotechnology called Single Transcriptome Assisted Rabies Tracing (START). The cutting-edge tool combines two advanced technologies-;monosynaptic rabies virus tracing and single-cell transcriptomics-;to map the brain's intricate neuronal connections with unparalleled precision.

1 Oct 2024

Study Reveals How Damaged Cells Contribute to Chronic Kidney Disease Progression

A study published in Nature Communications provides new insight into how damaged cells interact within disease-promoting microenvironments following acute kidney injury, or AKI.

6 Sep 2024

Study Utilizes Flow Cytometry and Advanced Transcriptomics to Reveal Age-Related Defects in Thymic Regeneration

Research identifies two states of age-associated thymic epithelial cells, linking thymic degeneration to aging and injury, impacting immune system function.

26 Aug 2024

Single-Cell Analysis Uncovers Impact of TREM2 Mutation on Beta-Amyloid Plaques

Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas to develop abnormal protein clumps, called beta-amyloid plaques, associated with late-onset Alzheimer's disease.

8 Aug 2024

High-Resolution Spatial Transcriptomics at Lower Cost

A novel spatial transcriptomics method that could revolutionize tissue sample gene expression profiling.

7 Aug 2024

The Role of Chemical Proteomics in Understanding Small Molecule-Protein Interactions

The various chemical proteomics methods with relevant examples.

31 Jul 2024

New ProteoCHIP EVO 96 Boosts Single-Cell Proteomics Sensitivity and Throughput

A label-free single-cell proteomics workflow that integrated the automated sample handling, optimal ion usage, and high-throughput capacities.

18 Jul 2024

High-resolution 3D maps of diseased tissues at the subcellular level

Molecular maps from patient tissue samples can be created with subcellular precision using an open-source platform created by researchers in the lab of Nikolaus Rajewsky at the Max Delbrück Center. This allows for in-depth analysis and may improve routine clinical pathology. The research was published in the journal Cell.

25 Jun 2024

Transcriptomics News and Research

Understanding Marine Worms’ Unique Ability to Regenerate Lost Body Parts

MIT Engineers Develop Model to Decode Complex Biological Systems

Unraveling the Spatial Complexity of Gene Expression with Seq-Scope

Innovative Genomic Technology Uncovers Mechanisms of Marjolin's Ulcer

A Novel Method for Improving Spatial Resolution in Transcriptomic Analysis

Proteomics Reveals Age-Related Changes in Mouse Bone Formation

Human Skin Map Gives ‘Recipe’ to Build Skin and Could Help Prevent Scarring

New Tool START Enables Precision Mapping of Neuronal Connectivity

Study Reveals How Damaged Cells Contribute to Chronic Kidney Disease Progression

Study Utilizes Flow Cytometry and Advanced Transcriptomics to Reveal Age-Related Defects in Thymic Regeneration

Single-Cell Analysis Uncovers Impact of TREM2 Mutation on Beta-Amyloid Plaques

High-Resolution Spatial Transcriptomics at Lower Cost

The Role of Chemical Proteomics in Understanding Small Molecule-Protein Interactions

New ProteoCHIP EVO 96 Boosts Single-Cell Proteomics Sensitivity and Throughput

High-resolution 3D maps of diseased tissues at the subcellular level

Study Identifies Three Distinct Subtypes of Clear Cell Renal Cell Carcinoma Using Radiomics and Transcriptomics

Tabulae Paralytica: Mapping Cellular Dynamics in Spinal Cord Injuries

Innovative ssREAD Database Provides Rich Alzheimer's Disease RNA-Seq Resources for Researchers

High-Accuracy DNA Methylation Clocks Illuminate Age-Related Changes in Primate Ovaries

New Computational Method STew Bridges Gap Between Gene Expression and Spatial Biology

Omics eBook

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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