Tyrosine News and Research

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A Novel Method for Incorporating Non-Canonical Amino Acids into Proteins

Every basic biology lesson teaches that proteins are made up of combinations of 20 distinct amino acids, which are ordered in various patterns similar to words.

12 Sep 2024

Insights into Peptide Clumping Could Transform Drug Design and Material Science

Scientists from China have investigated how short peptide chains aggregate together in order to deepen our understanding of the process, which is crucial for drug stability and material development.

4 Sep 2024

RYBREVANT Receives EC Nod for Advanced Lung Cancer Treatment

Janssen-Cilag International NV, a Johnson & Johnson company, today announced that the European Commission (EC) has approved a Type II extension of indication for RYBREVANT®▼ (amivantamab) in combination with chemotherapy (carboplatin and pemetrexed), for the treatment of adults with advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) Exon 19 deletions (ex19del) or Exon 21 L858R substitution (L858R) mutations, after failure of prior therapy including an EGFR tyrosine kinase inhibitor (TKI).

30 Aug 2024

Novel Drug Targets in Gardnerella Vaginalis: A Bioinformatics Approach to Combat Bacterial Vaginosis

A computational approach to identify proteins in G. vaginalis that could be potential drug targets.

20 Aug 2024

Cyclo(L-Pro-L-Tyr): A Promising Tyrosinase Inhibitor Derived from Skin Bacteria

Melanin protects the skin-;the body's largest organ and a vital component of the immune system-;from the damaging effects of ultraviolet (UV) radiation.

6 Aug 2024

Study Reveals Epigenetic Changes in Sperm from Non-Genetic Infertility Causes

How non-genetic factors can induce epigenetic modifications to the sperm and cause male infertility.

3 Jul 2024

3D Cell Cultures Improve Drug Screening Accuracy but Show Lower Efficacy for Anti-Cancer Drugs

The existing knowledge on monolayers and spheroid-based cell cultures, including the constituent compounds, and the difference in efficacy during drug screening, especially for anti-cancer drugs targeting cytoskeletal dynamics and cell cycles.

21 Jun 2024

Nutrient Nanomedicine Shows Promise Against Skin Cancer

An international research team has discovered a new way to effectively treat cancer, by using nutrients to reactivate suppressed metabolic pathways in cancer cells.

18 Jun 2024

Water-Soluble Bacterial Enzyme Could Enable Rapid Screening of Potential Antibiotics

A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a "hydrophobic" protein that loses its structure once removed from its normal location in the cell membrane.

11 Jun 2024

UC San Diego Researchers Find Cause of Cellular 'Short-Circuit'

A group of researchers at University of California San Diego has identified the cause of a "short-circuit" in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases.

5 Jun 2024

Stem Cell Factor Levels Show Promise in Predicting Successful IVF for Endometriosis

The ability of serum levels of stem cell factor to indicate the quality of oocyte and blastocyst development.

4 Jun 2024

C. elegans Study Reveals Impact of Embryonal Amphetamine Exposure

Amphetamine is a psychostimulant that has been used to treat a variety of brain dysfunctions. However, it is a highly abused drug.

31 May 2024

Breakthrough in Natural Vanillin Production Using Engineered Enzyme

Vanilla extract is one of the most widely used flavoring compounds in food products and cosmetics.

17 May 2024

How Gut Microbiome Modulation Affects Social Decision-Making

Taking pro- and prebiotics could make people more sensitive to fairness, even at the cost of earning less money, according to a study.

15 May 2024

Rare YKT6 Gene Variants Linked to New Neurological Disorder

A recent collaborative study has discovered rare variants in the YKT6 gene as the cause of a new neurological disorder characterized by developmental delays along with severe progressive liver disease and a potential risk for liver cancer.

2 Apr 2024

Novel Amino Acid Nanoparticles Offer Hope for Fighting Multi-Drug Resistant Cancers

Amino acids, such as tyrosine and tryptophan, are the fundamental building blocks that make up proteins.

9 Jan 2024

New Irreversible Inhibitor Overcomes Drug Resistance in Cancer Cells

The concept of irreversible inhibitors binding permanently to a target protein has garnered growing interest for potential applications in drug development.

30 Nov 2023

Novel Activation Mechanism for First Identified Oncogene

In the late 1970s, the link between the c-Src gene and cancer was unveiled, marking the identification of the inaugural oncogene.

1 Nov 2023

Live Broadcasting of “Growth Factor Signaling” Proteins Inside Living Cells

The “live reporter” technology, developed by synthetic biologists at Princeton University and Rice University, has shown that it is possible to expose, with a great deal more accuracy than is now possible, the functioning of networks of signaling proteins in living cells.

11 Jul 2023

New Genome Editing Technology Achieves Precise Targeted Insertion of DNA Segments

A new genome editing technology was developed by GAO Caixia’s group from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS). This technology achieves successful and accurate targeted insertion of large DNA segments in plants.

26 Apr 2023