Cell Biology

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Cryo-ET reveals mechanisms underlying gene mutations that lead to blindness

Researchers have discovered the structural determinants of the highly specialized rod outer segments membrane architecture of the eye, which plays a crucial role in vision.

7 Jan 2022

Researchers identify molecules responsible for dangerous neutrophil behavior

Researchers have found that circulating neutrophils—a kind of immune cell—acquire distinct behavior patterns during inflammatory processes.

7 Jan 2022

Research shows how bacteria silence potentially deadly genes

Humans are all made of collections of cells, where each cell contains instructions in the DNA to become another cell.

7 Jan 2022

Scientists use fruit fly embryos to study immune cell invasion

To fight infections and heal injuries, immune cells need to enter tissue. They also need to invade tumors to fight them from within.

7 Jan 2022

Novel delivery system for genome editing in vascular endothelial cells developed

The laboratory of Youyang Zhao developed a novel nanoparticle to deliver genome editing technology, such as CRISPR/Cas9, to endothelial cells, which line blood vessel walls.

7 Jan 2022

In vivo generation of engineered CAR T cells to treat heart injury

A novel immunotherapy strategy using in vivo generation of transient engineered chimeric antigen receptor (CAR) T cells, through the delivery of modified mRNA, can reduce fibrosis and restore cardiac function in a mouse model of heart failure, researchers report.

7 Jan 2022

T cell responses likely to protect against Omicron, says research

T cells are thought to be effective in setting up an immune response against Omicron despite the substantially higher mutations compared to earlier variants of concern.

7 Jan 2022

Researchers fine-tune an additional system for more efficient gene editing

Over the past decade, the CRISPR genome-editing system has revolutionized molecular biology, giving scientists the ability to alter genes inside living cells for research or medical applications. Now, researchers at Gladstone Institutes have fine-tuned an additional system for more efficient gene editing, using molecules called retrons.

6 Jan 2022

NRL scientists apply new methods to analyze cell behavior

Naval Research Laboratory researchers in the Chemistry Division apply their knowledge of biology in conjunction with materials to improve understanding of how cells and tissues organize and apply new methods to affect cell communication.

From United States Naval Research Laboratory 6 Jan 2022

Researchers discover a crucial and exploitable vulnerability in diffuse large B cell lymphomas

Aggressive and relatively common lymphomas called diffuse large B cell lymphomas (DLBCLs) have a critical metabolic vulnerability that can be exploited to trick these cancers into starving themselves, according to a study from researchers at Weill Cornell Medicine and Cornell's Ithaca campus.

4 Jan 2022

Researchers develop new CAR T cells that act as a "micropharmacy"

Immunotherapies called chimeric antigen receptor (CAR) T cells use genetically engineered versions of a patient's own immune cells to fight cancer. These treatments have energized cancer care, especially for people with certain types of blood cancers.

3 Jan 2022

Research highlights opportunities to expand the manufacture of stem cells in space

The secret to producing large batches of stem cells more efficiently may lie in the near-zero gravity conditions of space. Scientists at Cedars-Sinai have found that microgravity has the potential to contribute to life-saving advances on Earth by facilitating the rapid mass production of stem cells.

3 Jan 2022

Scientists discover how sponginess of stem cell nuclei controls cell differentiation

Researchers from Tokyo Metropolitan University have discovered how the sponginess and stickiness of stem cell nuclei controls how they "differentiate" into specialized cells. They found that the nucleus starts solid-like but becomes more fluid-like over time.

3 Jan 2022

Scientists shed light on mechanisms responsible for maturation of the splicing machinery

Alternative Splicing is an extraordinarily complex process that requires the coordinated action of multiple proteins, each specialized in very specific functions. These proteins are assembled and matured, forming a kind of consortium of proteins that perform these gene reading functions.

31 Dec 2021

Cryobioprinting uses a bioink embedded with cells to print frozen and complex structures

A new technique takes bioprinting -; in which an ink of cells is printed, layer by layer, to form a structure -; to a whole new, and icy level. Investigators from the Zhang lab at Brigham and Women's Hospital have developed a technology that they term "cryobioprinting," a method that uses a bioink embedded with cells to print frozen, complex structures that can be easily stored for later use.

31 Dec 2021

Severe lung injuries can trigger stem cells to undergo abnormal differentiation, study finds

Severe injuries to the lung from diseases such as COVID-19 trigger abnormal stem cell repair that alters the architecture of the lung. The aberrant stem cell differentiation in response to injury can prevent the restoration of normal lung function.

31 Dec 2021

Researchers grow intestinal organoids to study why bats infected with viruses do not succumb to diseases

Experiments attempting to explain why bats can be infected with many viruses at a time without succumbing to diseases such as COVID-19-;knowledge that could help us to reduce the threat to humans of infectious disease-;have struggled until now with the fact that live wild bats make poor research subjects.

30 Dec 2021

Study reveals a tug-of-war between genes inherited from the father and the mother

Cambridge scientists have identified a key signal that the fetus uses to control its supply of nutrients from the placenta, revealing a tug-of-war between genes inherited from the father and from the mother. The study, carried out in mice, could help explain why some babies grow poorly in the womb.

28 Dec 2021

Biochemical signals sent from cell to cell play a key role in deciding their fate

Scientists have found a way to prove that biochemical signals sent from cell to cell play an important role in determining how those cells develop.

24 Dec 2021

Simple, marine-dwelling creature shines light on cancer resistance

A simple, marine-dwelling creature known as Trichoplax adhaerens has some remarkable properties. The organism can tolerate unusually high doses of radiation that would kill most other forms of life. T. adhaerens has another intriguing characteristic: the ability to resist cancer.

24 Dec 2021

Cell Biology

Cryo-ET reveals mechanisms underlying gene mutations that lead to blindness

Researchers identify molecules responsible for dangerous neutrophil behavior

Research shows how bacteria silence potentially deadly genes

Scientists use fruit fly embryos to study immune cell invasion

Novel delivery system for genome editing in vascular endothelial cells developed

In vivo generation of engineered CAR T cells to treat heart injury

T cell responses likely to protect against Omicron, says research

Researchers fine-tune an additional system for more efficient gene editing

NRL scientists apply new methods to analyze cell behavior

Researchers discover a crucial and exploitable vulnerability in diffuse large B cell lymphomas

Researchers develop new CAR T cells that act as a "micropharmacy"

Research highlights opportunities to expand the manufacture of stem cells in space

Scientists discover how sponginess of stem cell nuclei controls cell differentiation

Scientists shed light on mechanisms responsible for maturation of the splicing machinery

Cryobioprinting uses a bioink embedded with cells to print frozen and complex structures

Severe lung injuries can trigger stem cells to undergo abnormal differentiation, study finds

Researchers grow intestinal organoids to study why bats infected with viruses do not succumb to diseases

Study reveals a tug-of-war between genes inherited from the father and the mother

Biochemical signals sent from cell to cell play a key role in deciding their fate

Simple, marine-dwelling creature shines light on cancer resistance

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