Cell Biology

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Animal model yields important insights into T cell exhaustion

T lymphocytes, or T cells, are an important component of our immune system. They can recognize foreign proteins, so-called antigens, as peptide fragments - for instance, those derived from viruses or cancer cells.

15 Feb 2021

Researchers use mouse models to explain how cancer cells spread

Most tumors consist of a heterogenous mix of cells. Genetic mutations found only in some of these cells are known to aid with the spread and progression of cancer.

15 Feb 2021

Study reveals key process by which plants switch between different stress responses

To design effective strategies that protect significant agricultural crops from climate change, it is important to understand how plants react to stressful environmental conditions.

15 Feb 2021

Study reveals a new role of SRC-3 protein in various cancers

New research has revealed a new role of the steroid receptor coactivator 3, also called SRC-3/NCOA3.

15 Feb 2021

Natural compounds in apples and other fruits may improve brain function

According to a new study, apples and other fruits contain natural substances that may help trigger the generation of new neurons in the brain.

15 Feb 2021

Tiny population of neurons may play a significant role in depression

A tiny population of neurons known to be important to appetite appear to also have a significant role in depression that results from unpredictable, chronic stress, scientists say.

12 Feb 2021

Enzyme in fruit fly larvae plays key role in waking up brain stem cells

Researchers studying an enzyme in fruit fly larvae have found that it plays an important role in waking up brain stem cells from their dormant 'quiescent' state, enabling them to proliferate and generate new neurons.

12 Feb 2021

Researchers identify protein sequences that might be used by SARS-CoV-2 to infect cells

Researchers at EMBL Heidelberg have identified sequences in human proteins that might be used by SARS-CoV-2 to infect cells. They have discovered that the virus might hijack certain cellular processes, and they discuss potentially relevant drugs for treating COVID-19.

12 Feb 2021

Cell cycle of cancer cells can be disrupted using two commercially available inhibitors

With two commercially available inhibitors, the cell cycle of the cancer cells in the childhood tumor neuroblastoma can be disrupted at a key point causing tumor cell death.

12 Feb 2021

New technique reveals natural structure of large enzyme complex

A new technique has revealed the natural structure of specifically massive and complex enzymes.

11 Feb 2021

Scientists identify mystery protein that explains the origins of Parkinson's Disease

Researchers have made a “vital step” toward inferring the origins of Parkinson’s disease—a neurological condition that is rapidly growing in the world.

11 Feb 2021

N-terminal acetylation shields proteins from degradation and inhibits programmed cell death

A new study shows that proteins called IAPs, which can trigger programmed cell death, are inhibited by a specific chemical modification, and reveals that they play a wider role in protein quality control than previously assumed.

11 Feb 2021

Seasonal human coronavirus antibodies not associated with protection against SARS-CoV-2

Past exposure to seasonal coronaviruses (CoVs), which cause the common cold, does not result in the production of antibodies that protect against the novel coronavirus SARS-CoV-2, according to a study led by Scott Hensley, PhD, an associate professor of Microbiology at the Perelman School of Medicine at the University of Pennsylvania.

11 Feb 2021

Inherited genetic variation plays a role in how patients respond to cancer immunotherapy

For all their importance as a breakthrough treatment, the cancer immunotherapies known as checkpoint inhibitors still only benefit a small minority of patients, perhaps 15 percent across different types of cancer. Moreover, doctors cannot accurately predict which of their patients will respond.

11 Feb 2021

Research may help better understand the biochemistry underlying catalysis in cells

Investigators from the Institute of Scientific and Industrial Research at Osaka University, together with the Hiroshima Institute of Technology, have announced the discovery of a new protein that allows an organism to conduct an initial and essential step in converting amino acid residues on a crosslinked polypeptide into an enzyme cofactor.

From Osaka University 11 Feb 2021

Scientists use new approach to avert drug resistance in glioblastomas

In far too many cases over the years, scientists have discovered promising new cancer treatments, only to report later that the tumor cells found ways to become resistant. These disappointing results have made overcoming drug resistance a major goal in cancer research.

11 Feb 2021

Researchers identify tumor suppressor gene involved in stress response

Even the larvae of the Drosophila fly contain adult progenitor cells. And these cells are the only ones that are preserved throughout the growth and are responsible for the development of adult tissues and organs.

11 Feb 2021

Light-activated protein can be used to study single synapses of neurons

Neurons are the primary cells of the nervous system, and the signals that are transmitted between them are responsible for all our actions and our cognitive ability.

10 Feb 2021

Researchers discover new molecular mechanism that promotes cell migration

Research groups at the University of Helsinki and Institut Jacques Monod, Paris, discovered a new molecular mechanism that promotes cell migration. The discovery sheds light on the mechanisms that drive the uncontrolled movement of cancer cells and also revises the 'textbook view' of cell migration.

10 Feb 2021

New therapeutic approach to restore the effectiveness of immune cells

Prompted by the need to improve conventional treatments for people infected with the human immunodeficiency virus (HIV-1), a team from the Institut national de la recherche scientifique (INRS) has identified a therapeutic approach to restore the effectiveness of immune cells.

10 Feb 2021

Cell Biology

Animal model yields important insights into T cell exhaustion

Researchers use mouse models to explain how cancer cells spread

Study reveals key process by which plants switch between different stress responses

Study reveals a new role of SRC-3 protein in various cancers

Natural compounds in apples and other fruits may improve brain function

Tiny population of neurons may play a significant role in depression

Enzyme in fruit fly larvae plays key role in waking up brain stem cells

Researchers identify protein sequences that might be used by SARS-CoV-2 to infect cells

Cell cycle of cancer cells can be disrupted using two commercially available inhibitors

New technique reveals natural structure of large enzyme complex

Scientists identify mystery protein that explains the origins of Parkinson's Disease

N-terminal acetylation shields proteins from degradation and inhibits programmed cell death

Seasonal human coronavirus antibodies not associated with protection against SARS-CoV-2

Inherited genetic variation plays a role in how patients respond to cancer immunotherapy

Research may help better understand the biochemistry underlying catalysis in cells

Scientists use new approach to avert drug resistance in glioblastomas

Researchers identify tumor suppressor gene involved in stress response

Light-activated protein can be used to study single synapses of neurons

Researchers discover new molecular mechanism that promotes cell migration

New therapeutic approach to restore the effectiveness of immune cells

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