Cell Biology

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Intricate Relationship Between Goblet Cells and the Gut Microbiome

In a new study, scientists from the University of California, San Diego have shed light on the crucial function goblet cells—specialized gut-lining cells—play in preserving a balanced and healthy immune environment in the gastrointestinal (GI) tract. Dr. Fernanda Raya Tonetti led the project, and Dr. Cristina Llorente made important contributions.

13 Nov 2024

A Closer Look at CAR T-Cell Therapy — Successes, Challenges, And Future

Chimeric antigen receptor T-cell therapy enhances immune response against cancer, with promising results in hematological malignancies and ongoing advancements.

13 Nov 2024

Cow Digestive Enzyme Shown to Break Down Tough Bacterial Biofilms

Most of the disease-causing bacteria secrete matrix-like layers around themselves called biofilms. These biofilms act as thick barriers limiting the entry of drugs and helping the bacteria become resistant to antibiotics.

12 Nov 2024

New Strategy Reinvigorates Exhausted T Cells to Fight Cancer

As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells -; which have lost their cancer-fighting oomph -; consume this lactic acid, which further saps their energy, according to new research from the University of Pittsburgh and UPMC Hillman Cancer Center.

11 Nov 2024

New Insights into the Molecular Basis of Mitochondrial Diseases

A significant finding about the energy production process of human cells has been made by researchers at the Karolinska Institute's Department of Cell and Molecular Biology.

11 Nov 2024

CRISPR Reveals Hidden Functions of Noncoding RNA

Genes contain instructions for protein production, with the central dogma of biology stating that this information flows from DNA to RNA to proteins.

8 Nov 2024

New Understanding of the Evolution of Multicellular Life

In 2017, the single-celled species Chromosphaera perkinsii was found in maritime sediments in Hawaii. More than a billion years ago, long before the first animals appeared on Earth, the earliest indications of its existence were found.

7 Nov 2024

Scientists Discover a Hidden Ally in the Fight Against Cancer

An intracellular sensor that tracks the quality of so-called MHC-I molecules which aid the immune system in identifying and eliminating dangerous cells, including tumor cells has been discovered by a global team headed by Goethe University Frankfurt.

7 Nov 2024

Study Reveals How Plants Override Genetic Instructions Through DNA Duplication

Biologists at Washington University in St. Louis have discovered the origin of a curious duplication that gives plants multiple ways to override instructions that are coded into their DNA.

7 Nov 2024

Astrocytes Play Key Role in Memory Storage and Recall, Study Shows

A study published in Nature by researchers at Baylor College of Medicine changes the way we understand memory.

7 Nov 2024

Ancient Protist May Hold Clues to Evolution of Multicellular Life

Chromosphaera perkinsii is a single-celled species discovered in 2017 in marine sediments around Hawaii. The first signs of its presence on Earth have been dated at over a billion years, well before the appearance of the first animals.

7 Nov 2024

How Neuroimmune Cells Modulate Immune Responses and Neuroinflammation

The brain, traditionally considered an immune-privileged organ due to the blood-brain barrier (BBB), has its own sophisticated immune defense system.

7 Nov 2024

MIT Engineers Develop Model to Decode Complex Biological Systems

Over the past two decades, new technologies have helped scientists generate a vast amount of biological data. Large-scale experiments in genomics, transcriptomics, proteomics, and cytometry can produce enormous quantities of data from a given cellular or multicellular system.

6 Nov 2024

Study Reveals How Chronic Immune Signaling Can Promote Cancer

Along with defending against pathogens, the body's innate immune system helps to protect the stability of our genomes in unexpected ways -; ways that have important implications for the development of cancer, researchers at Memorial Sloan Kettering Cancer Center (MSK) are discovering.

6 Nov 2024

16 Types of Nerve Cells Found to be Involved in Human Sense of Touch

No less than 16 different types of nerve cells have been identified by scientists in a new study on the human sense of touch.

6 Nov 2024

Gut Bacteria Influence Stress Responses Through Circadian Rhythms

A pioneering study has uncovered the vital role that gut microbiota plays in regulating stress responses by interacting with the body's circadian rhythms.

6 Nov 2024

Researchers Develop Synthetic Genes for Self-Assembling Biomaterials

Researchers from the UCLA Samueli School of Engineering and the University of Rome Tor Vergata in Italy have developed synthetic genes that function like the genes in living cells.

5 Nov 2024

APOE4 and Microglia Together Drive Alzheimer's Protein Deposits

In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein-;the most important genetic risk factor for Alzheimer's disease-;the same cells cause harmful inflammation and clumps of misfolded proteins, according to a new study by scientists at Gladstone Institutes.

5 Nov 2024

Novel Approach to Isolating and Quantifying EV Cargo for Disease Diagnosis

Parkinson's disease (PD) and Alzheimer's disease (AD) are examples of brain illnesses that begin to develop in patients far earlier than the onset of their initial clinical symptoms.

4 Nov 2024

The Role of Neural Crest Stem Cells in Cellular Reprogramming

Researchers at the University of Toronto have identified that neural crest stem cells, a group of cells located in the skin and other parts of the body, are the origin of reprogrammed neurons previously discovered by other scientists.

4 Nov 2024