Cell Biology

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Research Advances Understanding of Gene Expression Mechanisms

During embryonic development, cells start out as pluripotent, or have the potential to become many different cell types through differentiation.

17 Oct 2024

Unveiling the Potential of YY1 in Blood Cell Development and Therapy

Common lymphoid progenitors, pre-pro-B cells, pro-B cells, pre-B cells, immature B cells, and finally more mature and specialized B cells are the stages in which B cells, white blood cells that produce antibodies, develop.

17 Oct 2024

Peptide Inhibitor Could Revolutionize mRNA-Based Therapies

The new hope in the fight against diseases that cannot be cured is mRNA-based vaccinations and treatments.

17 Oct 2024

Transposable Elements Drive a Critical Transition in Early Embryogenesis

Researchers at Sinai Health have discovered that DNA elements known as transposons, which may travel throughout the genome, control a crucial stage in early human development instead of human genes.

16 Oct 2024

Proteomics Reveals Age-Related Changes in Mouse Bone Formation

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 19 on October 12, 2024, entitled, "A proteomics approach to study mouse long bones: examining baseline differences and mechanical loading-induced bone formation in young-adult and old mice."

16 Oct 2024

Transposable Elements Are Key to Normal Progression of Embryonic Cells

A critical transition in early human development is regulated not by our own genes, but by DNA elements called transposons that can move around the genome, Sinai Health researchers have found.

16 Oct 2024

Mutant Neurons Show Accelerated Development in Mouse Brain

The mechanisms behind intellectual disabilities and autism remain largely unknown. However, researchers from the labs of Prof. Pierre Vanderhaeghen and Prof. Vincent Bonin at the VIB-KU Leuven Center for Brain & Disease Research and NERF have identified that mutations in the SYNGAP1 gene interfere with the extended development of human neurons, a process believed to be critical for normal cognitive function.

15 Oct 2024

Researchers Develop Innovative Human Macrophage Model for Disease Study

A human cell culture model of the lung's most important immune cells, alveolar macrophages, helped make a key finding that is prompting researchers to rethink the role of another immune protein in infectious disease.

15 Oct 2024

Scientists Identify Key Role of Proteasome in Cell Death

Programmed cell death protects the body against cancer and other diseases. A team of researchers led by Professor Alexander Bartelt from the Institute for Cardiovascular Prevention (IPEK) has decoded a new mechanism by which oxidative stress influences cell death.

15 Oct 2024

New Mouse Model Shows Superior Ability to Study Human Immune Response to Cancer

Immunity plays a central role in the fight against cancer. Many of the current immunotherapies aim at helping the patient's immune system to better recognize cancer cells – by using engineered antibodies – or by simply providing it with new cells, pre-equipped to search and destroy cancer. Either way, what is paramount is a deep understanding of how the immune system works and confronts tumors.

15 Oct 2024

Scientists Uncover the Hidden Order in Chaotic Embryonic Development

Pipetting liquids into tiny test tubes, analyzing huge datasets, poring over research publications-;all these tasks are part of being a scientist.

15 Oct 2024

Disrupting a Gene Boosts T Cell Therapy, St. Jude Study Shows

Immunotherapy, using a patient's own immune system to treat disease, has shown promise in some patients with cancer but has not worked in most.

15 Oct 2024

Unveiling a New Cellular Phase for Protein Compartmentalization

Classical mixture theory, which takes into account the percentage corresponding to each constituent as well as the interactions among constituents, can be used to model a system made up of two substances in physics.

14 Oct 2024

New Insights Into the Antibacterial Function of GBP1 Proteins

An essential part of the human body's defense mechanism against infections is the protein GBP1.

14 Oct 2024

A New Technique Reveals the Behavior of OPCs in the Brain

Imagine yourself sometime in the far future aboard a routine rocket to Mars. Someone just spilled their drink. Without gravity, it collects in floating blobs that ripple right before your eyes. Now freeze.

14 Oct 2024

New Research Reveals Link Between Stress Response and C. difficile Severity

The portion of our nervous systems responsible for the "fight or flight" response can shape the severity of potentially deadly C. difficile infections, new research from the University of Virginia School of Medicine reveals.

14 Oct 2024

Single-Cell Sequencing Reveals New Insights into Immune Cell Interactions

A new review by Dr. Ruyuan Wang and an international team of researchers explores the complex interactions between the innate and adaptive immune systems, shedding light on regulatory mechanisms in infection, cancer, and autoimmune diseases.

14 Oct 2024

UC San Diego and UC Berkeley Collaborate on Innovative Antibiotic Resistance Solution

University of California San Diego and University of California Berkeley researchers have been awarded up to $7 million from the Advanced Research Projects Agency for Health (ARPA-H) to conduct research under the PROTECT project -; Pro/Prebiotic Regulation for Optimized Treatment and Eradication of Clinical Threats.

14 Oct 2024

Metabolic Profiling of Lung-Resident NK Cells Reveals Novel Therapeutic Targets

Trinity College Dublin researchers, based at St James's Hospital have provided important insights into the behavior and metabolic function of a previously largely unknown, but crucial 'natural killer' (NK) immune cell resident in the lungs.

14 Oct 2024

New Research Examines the Role of Skeletal Stem Cells in Bone Growth and Regeneration

Researchers at UTHealth Houston have been awarded an $8.1 million grant by the National Institutes of Health (NIH) to examine skeletal stem cells as potential drivers of craniofacial bone diseases and deformities. The study is led by Noriaki Ono, DDS, PhD, associate professor of orthodontics, and diagnostic and biomedical sciences at UTHealth Houston School of Dentistry.

14 Oct 2024