Drug Discovery & Pharmaceuticals

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Scientists Engineer the First CRISPR-Based Drug Candidate to Directly Target E. Coli

Many people have experienced infections from E. coli, which are primarily seen as inconvenient and unpleasant.

10 May 2023

Discovering Novel Senolytic Compounds with the Power of Artificial Intelligence

A new publication in the May issue of Nature Aging by researchers from Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, demonstrates the power of artificial intelligence (AI) to discover novel senolytic compounds, a class of small molecules under intense study for their ability to suppress age-related processes such as fibrosis, inflammation and cancer.

8 May 2023

New Insights on Cases of Post-Vaccine Heart Inflammation

Public health experts discovered an increase in cases of myocarditis, an inflammation of heart muscle, after the introduction of the new COVID-19 vaccinations two years ago, particularly in young males who had received mRNA vaccines.

8 May 2023

New AI System Could Help Advance the Field of Generative Biology

Researchers at the University of Toronto have developed an artificial intelligence system that can create proteins not found in nature using generative diffusion, the same technology behind popular image-creation platforms such as DALL-E and Midjourney.

5 May 2023

Multi-Angled Approach of Identifying Dual-Purpose Therapeutic Targets Implicated in Aging, Glioblastoma

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, "Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform."

3 May 2023

New Drug Development Method Could Lead to Cost-Effective Malaria Treatment

Southwest Research Institute (SwRI) and The University of Texas at San Antonio (UTSA) have developed a method to synthesize the highly potent antimalarial drug artemisinin, which could lead to a more cost-effective treatment for malaria.

3 May 2023

Argonne's Advanced Photon Source Helps Identify New Antibodies Against Coronaviruses

Results could speed development of new antivirals or vaccines that could counter many different coronavirus variants.

2 May 2023

Newly Identified Broad-Spectrum Antivirals Can Target Multiple Families of RNA Viruses

A new study has identified potential broad-spectrum antiviral agents that can target multiple families of RNA viruses that continue to pose a significant threat for future pandemics.

2 May 2023

Mirror-Image Versions of a Small Molecule Pave New Way for Cancer Drug Discovery

Scripps Research scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs.

28 Apr 2023

Novel 3D Structure can Serve as Blueprint to Engineer New BoNT/E Variants

A team of researchers from the University of California, Irvine, have revealed the first crystal structures of the receptor-binding domain of botulinum neurotoxin E (BoNT/E) in complex with its human neuronal receptors, synaptic vesicle glycoprotein 2A (SV2A).

28 Apr 2023

High-Throughput Assay to Analyze the Effects of CAR-T Cells Using Image Cytometry

The April 2023 issue of SLAS Discovery contains six full-length articles and one mini-review covering high-throughput screening (HTS) for protease-inhibiting drugs, high-content phenotypic screening and other life sciences research.

28 Apr 2023

Antibacterial Biologic Agent Effective Against Staphylococcus Aureus Infections in Early Tests

Researchers at NYU Grossman School of Medicine and Janssen Biotech, Inc. have shown in early tests that a bioengineered drug candidate can counter infection with Staphylococcus aureus – a bacterial species widely resistant to antibiotics and a major cause of death in hospitalized patients.

25 Apr 2023

New Type of Drug Could Offer a Solution to Tackle Multidrug-Resistant Bacteria

A new type of drug could provide a way to treat multidrug-resistant bacteria, according to a study published in Nature Communications.

19 Apr 2023

Research Identifies Protective Drugs that may Lessen the Collateral Damage Caused by Antibiotics

Antibiotics help to fight bacterial infections, but they can also harm the helpful microbes living in the gut, which can have long-lasting health consequences.

17 Apr 2023

Potential Therapy for Lethal Pediatric Brain Cancer Using ASO Technology

Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain cancer that often kills within a year of diagnosis. Surgery is almost impossible because of the tumors' location.

13 Apr 2023

Glycine-Based Tripeptide Treats Severe Form of Fatty Liver Disease in Non-Human Primates

A recently developed amino acid compound successfully treats nonalcoholic fatty liver disease in non-human primates -; bringing scientists one step closer to the first human treatment for the condition that is rapidly increasing around the world, a study suggests.

11 Apr 2023

Novel Tridimensional Anticancer Agents Have the Ability to Overcome Drug Resistance in Cancer Cells

A research team co-led by chemists from City University of Hong Kong recently discovered novel, highly effective anticancer agents with tridimensional structures, which have high anticancer activity, low toxicity and the ability to overcome drug resistance in cancer cells.

7 Apr 2023

Drug Discovery & Pharmaceuticals

Scientists Engineer the First CRISPR-Based Drug Candidate to Directly Target E. Coli

Discovering Novel Senolytic Compounds with the Power of Artificial Intelligence

New Insights on Cases of Post-Vaccine Heart Inflammation

New AI System Could Help Advance the Field of Generative Biology

Multi-Angled Approach of Identifying Dual-Purpose Therapeutic Targets Implicated in Aging, Glioblastoma

New Drug Development Method Could Lead to Cost-Effective Malaria Treatment

Argonne's Advanced Photon Source Helps Identify New Antibodies Against Coronaviruses

Newly Identified Broad-Spectrum Antivirals Can Target Multiple Families of RNA Viruses

Mirror-Image Versions of a Small Molecule Pave New Way for Cancer Drug Discovery

Novel 3D Structure can Serve as Blueprint to Engineer New BoNT/E Variants

High-Throughput Assay to Analyze the Effects of CAR-T Cells Using Image Cytometry

Antibacterial Biologic Agent Effective Against Staphylococcus Aureus Infections in Early Tests

New Type of Drug Could Offer a Solution to Tackle Multidrug-Resistant Bacteria

Research Identifies Protective Drugs that may Lessen the Collateral Damage Caused by Antibiotics

Potential Therapy for Lethal Pediatric Brain Cancer Using ASO Technology

Glycine-Based Tripeptide Treats Severe Form of Fatty Liver Disease in Non-Human Primates

Novel Tridimensional Anticancer Agents Have the Ability to Overcome Drug Resistance in Cancer Cells

Experts Unravel the Crystal Structure of CENP-E

New Shape-Shifting Antibiotics may Help Combat Drug-Resistant Superbugs

Single monoclonal antibody infusion can strengthen the body's fight against yellow fever

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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