Drug Discovery & Pharmaceuticals

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Cocklebur fruit shows potential to protect the skin and help enhance collagen production

The fruit of the cocklebur plant, which grows worldwide and is often considered a noxious weed, has antioxidant and anti-inflammatory components that could make it useful as a skin protectant, according to new research.

29 Mar 2023

New inhibitor molecule disrupts the infection mechanism of SARS-CoV-2 coronavirus

A team of scientists led by the Department of Energy's Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

29 Mar 2023

New compound may offer a way to prevent serious C. diff infections

Each year, about 500,000 people in the U.S. deal with gastrointestinal infections from Clostridioides difficile (C. diff), and more than 20,000 die from these infections.

27 Mar 2023

No more needles? Future vaccines could be delivered by a puff of air

In the future, vaccines may be delivered with a puff of air rather than a needle, according to the promising results of new research presented at a meeting of the American Chemistry Society this March.

27 Mar 2023

Using big data and machine learning to create multi-functional cancer drugs

Many cancer patients undergo treatment with multiple drugs, each of which attacks cancer in a different way, so the combination fights cancer on many fronts. But more drugs mean higher risks of side effects.

24 Mar 2023

Curcumin could enhance ovarian cancer treatments

A pharmacology researcher at New York Institute of Technology College of Osteopathic Medicine (NYITCOM) has co-authored a new study that makes a strong case for why a golden spice commonly found in curry could enhance ovarian cancer treatments.

23 Mar 2023

BetaLife and A*STAR team up to accelerate the development of new cell-based therapy for diabetes

Up-and-coming local biotech startup BetaLife Pte Ltd ("BetaLife") is collaborating with the Agency for Science, Technology and Research (A*STAR) to accelerate the development of next generation cell-based therapy for diabetes.

22 Mar 2023

How can the adoption of AI technology accelerate drug discovery?

In this interview, we speak to SLAS 2023 keynote speaker Joshua Smith from IBM Research about the importance of AI in accelerating drug discovery.

From Society for Laboratory Automation and Screening (SLAS) 22 Mar 2023

Genetic signature might be shared across multiple substance use disorders, new study reveals

A new study has revealed a common genetic signature that seems to underlie multiple substance use disorders.

22 Mar 2023

Gyros Protein Technologies introduces new PurePep EasyClean services to accelerate development and manufacturing of peptide-based drugs

Gyros Protein Technologies AB today announced the launch of three service offerings to support development and manufacturing of peptide-based drugs.

From Gyros Protein Technologies AB 22 Mar 2023

Researchers uncover the role of third intracellular loop in GPCR's signaling mechanism

More than a third of FDA-approved drugs work by targeting a G protein-coupled receptor, or GPCR. The human body has more than 800 types of GPCRs that provide cells with information about the external environment to calibrate responses.

20 Mar 2023

New antibody "cocktail" may help counter the Lassa virus

The finding, made with the use of the Advanced Photon Source, shows a new way to exploit monoclonal antibodies to subvert the "shield" of the virus, potentially paving the way for new therapies.

20 Mar 2023

Delaying paralysis in ALS by using designer DNA drug

In virtually all persons with amyotrophic lateral sclerosis (ALS) and in up to half of all cases of Alzheimer's disease (AD) and frontotemporal dementia, a protein called TDP-43 is lost from its normal location in the nucleus of the cell.

20 Mar 2023

Fomepizole may reduce disease severity in the lungs of mice with bacterial pneumonia

Pneumococcal disease leads to over three million hospitalizations and hundreds of thousands of deaths annually.

17 Mar 2023

Rice biologists embark on a three-year project to create genetically encoded antibiotics

Synthetic biologists at Rice University are embarking on a three-year project to create "genetically encoded antibiotics," strands of RNA that bacteria will readily copy and share that will selectively kill only disease-causing, pathogenic bacteria.

14 Mar 2023

SMART researchers develop the world's first microneedle-based drug delivery technique for plants

Researchers from the Disruptive & Sustainable Technologies for Agricultural Precision (DiSTAP) Interdisciplinary Research Group (IRG) of Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, and their collaborators from Temasek Life Sciences Laboratory (TLL) and Massachusetts Institute of Technology (MIT), have developed the first-ever microneedle-based drug delivery technique for plants.

14 Mar 2023

New class of oral drugs inhibits a diverse range of SARS-CoV-2 strains

The constant evolution of new COVID-19 variants makes it critical for clinicians to have multiple therapies in their arsenal for treating drug-resistant infections. Researchers have now discovered that a new class of oral drugs that acts directly on human cells can inhibit a diverse range of pathogenic SARS-CoV-2 strains.

13 Mar 2023

LDL-mediated nanoparticle drug delivery could potentially circumvent high-grade gliomas

New research has shown that the blood vessels that feed aggressive brain tumors have receptors that could allow a new type of drug-containing nanoparticle to be used to starve the tumors of the energy they use to grow and spread, and also cause other disruptions to their adapted existence, even killing themselves.

8 Mar 2023

Revolutionary drug blocks a gene associated with driving the spread of bone cancer

Researchers at the University of East Anglia have developed a new drug that works against all of the main types of primary bone cancer.

8 Mar 2023

Novel framework provides solutions to evade detoxification networks

Scientists at St. Jude Children's Research Hospital have demonstrated how drug makers can avoid two key problems: toxicity and resistance. The researchers made slight changes to a small molecule to reduce its metabolism and elimination by the cellular detoxification network regulated by the pregnane X receptor (PXR). This research provides a framework to develop solutions to the long-standing issue of how to evade detoxification networks using medicinal chemistry. The findings were published today in Proceedings of the National Academy of Sciences.

1 Mar 2023

Drug Discovery & Pharmaceuticals

Cocklebur fruit shows potential to protect the skin and help enhance collagen production

New inhibitor molecule disrupts the infection mechanism of SARS-CoV-2 coronavirus

New compound may offer a way to prevent serious C. diff infections

No more needles? Future vaccines could be delivered by a puff of air

Using big data and machine learning to create multi-functional cancer drugs

Curcumin could enhance ovarian cancer treatments

BetaLife and A*STAR team up to accelerate the development of new cell-based therapy for diabetes

How can the adoption of AI technology accelerate drug discovery?

Genetic signature might be shared across multiple substance use disorders, new study reveals

Gyros Protein Technologies introduces new PurePep EasyClean services to accelerate development and manufacturing of peptide-based drugs

Researchers uncover the role of third intracellular loop in GPCR's signaling mechanism

New antibody "cocktail" may help counter the Lassa virus

Delaying paralysis in ALS by using designer DNA drug

Fomepizole may reduce disease severity in the lungs of mice with bacterial pneumonia

Rice biologists embark on a three-year project to create genetically encoded antibiotics

SMART researchers develop the world's first microneedle-based drug delivery technique for plants

New class of oral drugs inhibits a diverse range of SARS-CoV-2 strains

LDL-mediated nanoparticle drug delivery could potentially circumvent high-grade gliomas

Revolutionary drug blocks a gene associated with driving the spread of bone cancer

Novel framework provides solutions to evade detoxification networks

Driving Support for Pharmaceutical Testing Through Continuous Innovation

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