Genomics

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Study Reveals How Male Ruff Birds Use a "Super Enzyme" to Tame Excess Testosterone

We normally associate high testosterone levels with male dominance and aggression. Among ruffs – a shore bird that breeds across Europe and Asia – some males suffer from too much of it.

24 Jan 2025

New Research Sheds Light on Y Chromosome’s Role in Male Infertility

Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice.

24 Jan 2025

Study Unveils Key Genetic Mechanism Behind Antibiotic Resistance in Bacteria

An international collaboration has achieved an important breakthrough in understanding the genetic mechanisms that allow bacteria to build resistance to drugs.

24 Jan 2025

New Insights into the Biological Basis of Bipolar Disorder

According to research published in Nature on January 22nd, 2025, an international team of psychiatric genetics researchers has discovered 298 regions of the genome with DNA variations that increase the risk for bipolar disorder, more than four times the number previously found.

24 Jan 2025

Breakthrough Achieved in Completing the Creation of First Synthetic Yeast Genome

Macquarie University researchers have worked with an international team of scientists to achieve a major milestone in synthetic biology by completing the creation of the final chromosome in the world's first synthetic yeast genome.

23 Jan 2025

New Map Reveals How Human DNA Shuffles During Reproduction

Scientists at deCODE genetics/Amgen have constructed a complete map of how human DNA is mixed as it is passed down during reproduction.

23 Jan 2025

Epigenetic Aging and DNA-Methylation May Help Predict Breast Cancer Susceptibility

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) on December 5, 2024, Volume 16, Issue 22, titled "DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility."

22 Jan 2025

Genetic Mutations May Be Behind Epigenetic Clock of Aging

Researchers at University of California San Diego School of Medicine have published results that shed new light on an old question: what causes aging at the molecular level? Their findings, published in Nature Aging, describe a never-before-seen link between the two most accepted explanations: random genetic mutations and predictable epigenetic modifications.

22 Jan 2025

Mapping Global Microbial Diversity Using Genomic Sequencing Data

Metagenomic datasets could help map out microbial diversity hotspots. Published January 17, 2025 in Science Advances, researchers at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility located at Berkeley Laboratory, have taken stock of the current state of microbial genomic biodiversity.

20 Jan 2025

Mapping of Neuronal IL-1R1 Expression in the Mouse Brain Sheds Light on Mood and Memory

Interleukin-1 (IL-1) is a key molecule involved in inflammation and plays an important role in both healthy and diseased states.

20 Jan 2025

Understanding the Impact of Microbial Associations on Insect Evolution

The evolutionary success of leaf beetles, the most varied herbivores on Earth, was investigated by researchers from the Max Planck Institute for Chemical Ecology in Jena, Max Planck Institute of Biology in Tübingen, Germany, and a group of scientists from around the world.

20 Jan 2025

GET Model Unveils Gene Regulation with Unmatched Accuracy Across Cell Types

GET, a novel computational model, accurately predicts gene activity by analyzing chromatin accessibility and DNA sequences across diverse human cell types.

20 Jan 2025

Deep Sea Foraminifera Species Unveil Secrets of Life in Extreme Environments

Most life on Earth relies on the sun's energy for survival, but what about organisms in the deep sea that live beyond the reach of its rays? A new study led by Woods Hole Oceanographic Institution (WHOI), published in The ISME Journal, sheds light on how a species of foraminifera, single-celled organisms found in almost all marine habitats, thrives in a dark, oxygen-free environment.

17 Jan 2025

Study Unveils Surprising Cause of Brain Cell Death in Huntington's Disease

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of brain cells.

17 Jan 2025

New study reveals how genes switch on and off in human cells

An international group of scientists has made a significant advancement in their understanding of the regulation of gene expression throughout the human genome.

17 Jan 2025

New Approach Aims to Make CRISPR Therapy Safer and More Effective

CRISPR is a powerful gene-editing tool that holds enormous potential for treating genetic diseases by allowing scientists to cut, replace, or delete mutations in DNA.

16 Jan 2025

Epigenetic Mechanism Controls Placental Blood Vessel Formation

If the development of blood vessels in the placenta is impaired, fetal growth retardation may result. Scientists from the German Cancer Research Center (DKFZ) and the Mannheim Medical Faculty of Heidelberg University discovered that the correct development of functioning blood vessels in the mouse placenta is controlled epigenetically: One of the enzymes that modify gene activity using methyl groups is responsible.

16 Jan 2025