Genomics

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Comprehensive genetic analysis reveals complex origins of Tibetan-Yi corridor ethnic groups

China's mountainous southwestern area is home to one of the country's most ethnically diverse populations.

27 Apr 2022

Genetic variations in key mitochondrial enzyme associated with age-related mobility changes

Age-related changes in strength and mobility may depend on genetic variations in a critical mitochondrial enzyme, suggests a study published today in eLife.

27 Apr 2022

Researchers discover a unique origin of severe pediatric brain cancer

A new cause of severe childhood brain cancer has been discovered by scientists.

25 Apr 2022

Minor genetic differences impact the ability to utilize the energy of various nutrients

All animals require proteins, carbohydrates, and fats to survive. However, dietary differences between species, populations, and individuals can be significant.

25 Apr 2022

Study identifies novel targets for treating sorafenib-resistant hepatocellular carcinoma

Research headed by Professor Xiujun Cai used the CRISPR/cas9 system to screen the entire genome of hepatocellular carcinoma cells (HepG2) under sorafenib treatment.

25 Apr 2022

Study underscores the crucial role of genomic profiling in diagnosing and grading brain tumors

Patients diagnosed with a type of brain tumor survived for longer when they were treated aggressively with surgery, radiation and chemotherapy.

22 Apr 2022

Cornell scientists explore how human genetics impacts gut microbiome function

New research from Cornell scientists is exploring how human genetics impacts functions of the gut microbiome, and is expanding awareness of the role human genetics plays in shaping the microbiome.

22 Apr 2022

Study shows how whole genome sequencing test reveals details about cancer growth

Professor Serena Nik-Zainal of Cambridge University Hospitals (CUH) and the University of Cambridge headed a group of scientists that analyzed the whole genetic make-up or whole-genome sequencing (WGS) of over 12,000 NHS cancer patients in the largest research of its type.

22 Apr 2022

Study highlights an effective technique to overcome the rice yield constraint

Tradeoffs between diverse agronomic traits constrain crop breeding to a great extent. Because gene pleiotropy causes many of these tradeoffs, lowering gene pleiotropy may make it simpler to overcome tradeoffs in plant breeding.

22 Apr 2022

Extra copies of DNA explain insensitivity to chemotherapy in germ cell cancer

Extra copies of a piece of DNA partly explain insensitivity to chemotherapy in germ cell cancer, a new study shows.

21 Apr 2022

Alzheimer’s patients tend to have differed and increased genetic changes, says study

Errors present in DNA can get accumulated inside brain cells as one is aging. However, in patients with Alzheimer’s disease, these errors called somatic mutations may increase at a quicker rate.

21 Apr 2022

Researchers analyze single-cell DNA sequencing for having a significant role in Alzheimer’s disease

The loss of functional neurons in the brain is a characteristic of Alzheimer’s disease. What, on the other hand, is the source of this loss?

21 Apr 2022

Genomics provides a deeper understanding of the cause of hydrocephalus

The cerebral ventricles—four linked cavities of the brain that are packed with cerebrospinal fluid—become enlarged in hydrocephalus, or “water on the brain;” however, the cause is unknown in many instances.

20 Apr 2022

Zbtb38 removal results in early embryonic death

DNA methylation is a critical epigenetic alteration for mammalian development.

20 Apr 2022

Study identifies new targets for treating sorafenib-resistant hepatocellular carcinoma using CRISPR-Cas9 screening

This study is led by Xiujun Cai (Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine). Professor Xiujun Cai's research team screened the whole genome of hepatocellular carcinoma cells (HepG2) through CRISPR / cas9 system under sorafenib treatment, and screened the dominant gene in sorafenib resistance.

20 Apr 2022

Study provides a deeper understanding of how gene mutations contribute to breast cancer progression

A mutated gene found in more than 20% to 30% of breast cancer recurrences may help tumors become more aggressive and promote metastasis, according to a pair of new studies that uncover mechanisms behind these processes and point to new therapy targets.

From University of Pittsburgh 20 Apr 2022

Genomics

Comprehensive genetic analysis reveals complex origins of Tibetan-Yi corridor ethnic groups

Genetic variations in key mitochondrial enzyme associated with age-related mobility changes

Researchers discover a unique origin of severe pediatric brain cancer

Minor genetic differences impact the ability to utilize the energy of various nutrients

Study identifies novel targets for treating sorafenib-resistant hepatocellular carcinoma

Study underscores the crucial role of genomic profiling in diagnosing and grading brain tumors

Cornell scientists explore how human genetics impacts gut microbiome function

Study shows how whole genome sequencing test reveals details about cancer growth

Study highlights an effective technique to overcome the rice yield constraint

Extra copies of DNA explain insensitivity to chemotherapy in germ cell cancer

Alzheimer’s patients tend to have differed and increased genetic changes, says study

Researchers analyze single-cell DNA sequencing for having a significant role in Alzheimer’s disease

Genomics provides a deeper understanding of the cause of hydrocephalus

Zbtb38 removal results in early embryonic death

Study identifies new targets for treating sorafenib-resistant hepatocellular carcinoma using CRISPR-Cas9 screening

Study provides a deeper understanding of how gene mutations contribute to breast cancer progression

Deeper understanding of genomics support researchers discover new perceptions

Epigenetic regulator helps determine lung cancer patients and their resistance to drugs

Researchers develop epigenetic methods for effective cancer treatments

Researchers use CRISPR gene editing tool to analyze globin gene switching

Driving Support for Pharmaceutical Testing Through Continuous Innovation

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