Histology & Microscopy

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'Little brain' contains almost 80% of the cerebral cortex’s surface area

When we say someone has a quick mind, it may be in part thanks to our expanded cerebellum that distinguishes human brains from those of macaque monkeys, for example.

3 Aug 2020

'Marie Kondo' enzyme helps fruit fly embryos to clean out maternal proteins

Researchers at the University of Colorado School of Medicine have discovered a protein in fruit fly embryos, dubbed Marie Kondo, that destroys maternal proteins.

29 Jul 2020

Deep learning algorithm can infer molecular alterations in cancer from histology images

Researchers at the University of Chicago Medicine Comprehensive Cancer Center, working with colleagues in Europe, created a deep learning algorithm that can infer molecular alterations directly from routine histology images across multiple common tumor types.

29 Jul 2020

AI algorithm can identify patterns of mutations and prognosis from tumor images

Researchers at EMBL's European Bioinformatics Institute, the Wellcome Sanger Institute, Addenbrooke's Hospital in Cambridge, UK, and collaborators have developed an artificial intelligence algorithm that uses computer vision to analyse tissue samples from cancer patients.

28 Jul 2020

Novel label-free imaging method can differentiate between quiescent and activated T cells

T cells are the immune soldiers at the frontlines of the battle with infiltrating pathogens that seek to cause disease. A new study published in Nature Biomedical Engineering describes a novel label-free imaging technique that can differentiate active T cells from those off duty.

28 Jul 2020

Evaluating the impact of sugary and acidic drinks on tooth enamel

Using atomic force microscopy, researchers have quantitatively assessed the effect of sugary and acidic drinks on human tooth enamel at the nanoscale level.

23 Jul 2020

A novel technique to control and visualize functions of living cells

A research group composed of Professor Takayuki Shibata and his colleagues at Department of Mechanical Engineering, Toyohashi University of Technology has given greater functionalities to atomic force microscopy (AFM).

23 Jul 2020

Researchers image the formation of four-stranded DNA in living human cells

The development of four-stranded DNA has been monitored in the living cells of human beings, enabling researchers to observe its potential role in cancer.

21 Jul 2020

Advanced cryo-EM reveals stunning details of viral RNA replication complex structure

For the first time, scientists at the Morgridge Institute for Research have generated near atomic resolution images of a major viral protein complex responsible for replicating the RNA genome of a member of the positive-strand RNA viruses, the large class of viruses that includes coronaviruses and many other pathogens.

21 Jul 2020

New method reveals the dynamics of HIV Gag-protein lattice structure

Viruses are scary. They invade our cells like invisible armies, and each type brings its own strategy of attack. While viruses devastate communities of humans and animals, scientists scramble to fight back.

17 Jul 2020

Researchers use super-resolution microscopy to study close protein associations

With the advent of super-resolution microscopy, scientists can study close protein associations better than ever before.

10 Jul 2020

Structural analysis of SARS-CoV-2 spike protein offers clues about the virus' evolution

Researchers at the Francis Crick Institute have characterized the structure of the SARS-CoV-2 spike protein as well as its most similar relative in a bat coronavirus. The structures provide clues about how the spike evolved and could help inform vaccine design.

10 Jul 2020

Scientists discover role of surface diffusion in protein transport

Many of the most promising medicines under development are proteins, often antibodies, to help patients fight disease. These proteins must be purified as part of the manufacturing process -- a task that can be tricky and result in costly waste.

8 Jul 2020

Harvard neurobiologists provide new insights into the mystery of scent

The premiere of the movie Scent of Mystery in 1960 marked a singular event in the annals of cinema: the first, and last, motion picture debut "in glorious Smell-O-Vision."

3 Jul 2020

Light-sheet microscope allows gentle, non-invasive observation of corals

Many corals are sensitive to bright light, so capturing their dynamics with traditional microscopes is a challenge.

2 Jul 2020

Scientists develop new experimental approach to study molecular interactions

When two cars collide at an intersection -- from opposite directions -- the impact is much different than when two cars -- traveling in the same direction -- "bump" into each other.

2 Jul 2020

Researchers track how key brain receptor works

For the first time, researchers in the lab of CSHL Professor Hiro Furukawa have been able to track each atom in the NMDA receptor, an important brain protein, as it transmits or inhibits neural signals.

1 Jul 2020

Princeton researcher solves long-standing mysteries of membrane protein structure

Ion channels and membrane transporters are in the business of moving ions and small molecules across cellular membranes. They are essential for metabolic and cellular homeostasis, and for a host of biological signaling pathways.

30 Jun 2020

Super-resolution technology helps visualize DNA replication in single human cells

DNA replication is a process of critical importance to the cell, and must be coordinated precisely to ensure that genomic information is duplicated once and only once during each cell cycle.

26 Jun 2020

New microscope looks at the different parameters that change during wound healing

Researchers at the GSK Center for Optical Molecular Imaging have developed a new microscope that looks at the different parameters that change during wound healing. They hope to use this technique to understand how skin disorders, such as foot ulcers in diabetic patients and psoriasis, can be treated.

18 Jun 2020