Histology & Microscopy

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Altered sugar composition impacts cell-to-surface adhesion

Biotechnologists measure the forces with which algae cells adhere to surfaces and move on them. How can cells adhere to surfaces and move on them? This is a question that was investigated by an international team of researchers headed by Prof. Michael Hippler from the University of Münster and Prof. Kaiyao Huang from the Institute of Hydrobiology (Chinese Academy of Sciences, Wuhan, China).

4 Jan 2021

Scientists develop novel approach to acquire fluorescence lifetime images

Fluorescence microscopy is widely used in biochemistry and life sciences because it allows scientists to directly observe cells and certain compounds in and around them. Fluorescent molecules absorb light within a specific wavelength range and then re-emit it at the longer wavelength range.

4 Jan 2021

TUM researcher develops self-learning algorithms to help analyze bioscientific image data

Imaging techniques enable a detailed look inside an organism. But interpreting the data is time-consuming and requires a great deal of experience.

29 Dec 2020

High-speed atomic force microscopy sheds light on structure, dynamics of intrinsically disordered proteins

Kanazawa University’s pioneering high-speed atomic force microscope technology has now shed light on the structure and dynamics of some of life’s most ubiquitous and inscrutable molecules – intrinsically disordered proteins.

29 Dec 2020

Highly developed microscopy methods can help detect antigens

Highly complicated processes constantly take place in our body to keep pathogens in check: The T-cells of our immune system are busy searching for antigens - suspicious molecules that fit exactly into certain receptors of the T-cells like a key into a lock. This activates the T-cell and the defense mechanisms of the immune system are set in motion.

22 Dec 2020

Novel microscope could allow surgeons to inspect cancer margins in minutes

When surgeons remove cancer, one of the first questions is, "Did they get it all?" Researchers from Rice University and the University of Texas MD Anderson Cancer Center have created a new microscope that can quickly and inexpensively image large tissue sections, potentially during surgery, to find the answer.

21 Dec 2020

Microglia surveillance helps prevent seizure activity in the brain

An important part of the brain's immune system, cells called microglia constantly extend and retract "branches" from their cell body to survey their environment.

15 Dec 2020

Researchers set a new record in X-ray microscopy

Researchers at Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), the Paul Scherrer Institute in Switzerland and other institutions in Paris, Hamburg and Basel, have succeeded in setting a new record in X-ray microscopy.

14 Dec 2020

Research clarifies regulatory impacts of ubiquitin-proteasome system on DNA damage repair

An international research team has clarified the regulatory mechanism of the ubiquitin-proteasome system (*1) in recognizing and repairing DNA that has been damaged by ultraviolet (UV) light.

9 Dec 2020

Researchers discover molecular mechanism of plant immune receptors

In a recent study, Alexander von Humboldt Professor Jijie Chai at the University of Cologne and his team together with MPIPZ researchers have succeeded for the first time in reconstructing the sequence of molecular events that activate an inactive plant immune receptor and thus mediate the death of the host cell.

8 Dec 2020

CRISPR-based test for COVID-19 provides quick, accurate results

Imagine swabbing your nostrils, putting the swab in a device, and getting a read-out on your phone in 15 to 30 minutes that tells you if you are infected with the COVID-19 virus.

7 Dec 2020

Researchers use super-resolution microscopy to study bacterial infection mechanisms

Expansion microscopy, abbreviated as ExM, allows scientists to image cells and their components with a spatial resolution down to 200 nm.

4 Dec 2020

New breakthrough in microscopy and endoscopy may advance the field of precision medicine

A breakthrough in microscopy and endoscopy will soon revolutionize the study of the cellular origin of diseases, advancing the field of precision medicine.

3 Dec 2020

Researchers present holographic Raman microscopy for biological sensing applications

Raman spectroscopy is widely used in analytical sciences to identify molecules via their structural fingerprint. In the biological context, the Raman response provides a valuable label-free specific contrast that allows distinguishing different cellular and tissue contents.

1 Dec 2020

Scientists elucidate the structure of ABC transporter protein

A high concentration of salt or sugar in the environment will dehydrate microorganisms and stop them from growing.

19 Nov 2020

Gold nanoparticles put spotlight on small drug molecules in live cells

Successful drug development has a significant impact on people's quality of life worldwide. Being able to track how molecules get into target cells, and observing what they do when they are inside, is key to identifying the best candidates.

From Osaka University 19 Nov 2020

New study shows patients' own stem cells can be used to grow new bone

A new, groundbreaking study from the University of Bergen (UiB) shows that a patients' own stem cells can be used to grow new bone. This can potentially help millions of people who are partially edentulous and have insufficient bone for the placement of dental implants.

17 Nov 2020

Glass surface embedded with self-assembled gold nanoparticles can improve live-cell imaging

In the quest to image exceedingly small structures and phenomenon with higher precision, scientists have been pushing the limits of optical microscope resolution, but these advances often come with increased complication and cost.

9 Nov 2020

Experts use super-resolution microscopy to observe individual synapse proteins

In the synapses of nerve cells (neurons), there are hundreds of specialized proteins that are important for the functioning of the nervous system. If something goes wrong here, neurological or psychiatric diseases can be the result - Alzheimer's and Parkinson's, depression, and schizophrenia are just a few of them.

6 Nov 2020

Researchers reveal identity of the last unknown protein of autophagy

Drs. Nobuo Noda (Director) and Kazuaki Matoba (Senior Researcher) et al. at the Institute of Microbial Chemistry (BIKAKEN, Tokyo, Japan) discovered that Atg9, one of the proteins that function to mediate autophagy, has phospholipid-translocation activity (the lipid scramblase activity) between the two layers of the lipid bilayer and elucidated that the protein's activity brings about autophagosome membrane expansion.

5 Nov 2020