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Study Unveils Surprising Cause of Brain Cell Death in Huntington's Disease

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of brain cells.

17 Jan 2025

Inflammasome Helps Block Malignancy in Blood Stem Cells

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.

17 Jan 2025

Long Reads Show Promise for Diagnosing Rare Genetic Disorders

The cause of rare diseases is increasingly being detected through genome sequencing, which involves reading the entire human DNA by first breaking it into small pieces-short reads.

16 Jan 2025

Unrepaired DNA Damage Can Persist for Years and Lead to Cancer Mutations

While most known types of DNA damage are fixed by our cells’ in-house repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that the damage has multiple chances to generate harmful mutations, which can lead to cancer.

15 Jan 2025

Base Editing Technique Extends Lifespan in Prion Disease Mouse Model

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition.

15 Jan 2025

Researchers Predict U.S. Dementia Cases Will Double by 2060

Unveiling a looming health crisis: how shifting demographics and genetic risks are driving a dramatic rise in dementia cases.

14 Jan 2025

Neuropilin2 Gene Disruption Impacts Brain Circuitry in Autism and Epilepsy

The gene neuropilin2 encodes a receptor involved in cell-cell interactions in the brain and plays a key role in regulating the development of neural circuits.

10 Jan 2025

Bioengineered Vessels Offer Alternative to Synthetic Grafts for Vascular Repairs

A new type of bioengineered blood vessel showed strong results in treating severe vascular injuries, potentially offering vascular surgeons a better alternative to synthetic grafts when patients' veins aren't suitable for use in repairs.

10 Jan 2025

New Gene Editing Therapy Shows Promise for Treating Stargardt Disease

Researchers have developed a highly efficient gene editing therapy that could potentially treat Stargardt disease, the most common form of inherited macular degeneration.

10 Jan 2025

Mapping the Aging Brain: A Single-Cell View of Transcriptomic Changes

Research reveals how aging impacts gene expression across brain cell types, identifying critical changes in the hypothalamus linked to health and function.

9 Jan 2025

New Mechanism Revealed for Immune Response to DNA Damage

A research team from the University of California, Irvine has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged.

7 Jan 2025

Uncovering Key Differences Between Humans and Mice in Cancer Immunotherapy Targets

“Programmed cell death protein 1,” or PD-1, has been considered a key target in cancer therapies since its discovery in the 1990s.

6 Jan 2025

Zebrafish Protein Promotes Cardiac Repair in Mice

Researchers from the Hubrecht Institute's Bakkers group have used a zebrafish protein to successfully repair damaged mouse hearts.

3 Jan 2025

Molecular Lantern Technique Could Revolutionize Brain Pathology Monitoring

Monitoring the changes caused in the brain at the molecular level by cancer and other neurological pathologies in a non-invasive way is one of the great challenges of biomedical research.

2 Jan 2025

Bumetanide Treatment Alters Early and Late Social Behaviors in Fragile X Mice

In a comprehensive Genomic Press Interview, researchers from the University of Texas Health Science Center at San Antonio and Hirosaki University have uncovered critical new insights into the developmental trajectory of social behaviors in fragile X syndrome, the leading genetic cause of autism spectrum disorder.

30 Dec 2024

Research Reveals Regulatory Role of Glucose-6-Phosphate Dehydrogenase in Mitophagy

Mitophagy is a selective form of autophagy via which the damaged mitochondria are cleared via the autophagy-lysosome pathway.

30 Dec 2024

Stress Pathway in Microglia Found to Contribute to Alzheimer's Neurodegeneration

Researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have unveiled a critical mechanism that links cellular stress in the brain to the progression of Alzheimer's disease (AD).

26 Dec 2024

New Treatment Targets Tumor Microenvironment to Fight Breast Cancer

"Build your enemy a golden bridge to retreat across" is a piece of advice offered by Sun Tzu in his ancient military treatise, The Art of War. It turns out that cancerous growths adopt this strategy in their battle against the immune system.

24 Dec 2024

Digital Twin Technology Reverses Colon Cancer in Study by KAIST Researchers

Despite the development of numerous cancer treatment technologies, the common goal of current cancer therapies is to eliminate cancer cells. This approach, however, faces fundamental limitations, including cancer cells developing resistance and returning, as well as severe side effects from the destruction of healthy cells.

24 Dec 2024

Discovery of ALAS1's Secret Role Could Boost Cancer Therapy Development

In everyday life, when things turn out the opposite of what you expect, it's usually cause for frustration. In science, it's often the starting point for discovery.

23 Dec 2024