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Lack of Genetic Diversity in Reference Groups Leads to Misdiagnoses

A new study has uncovered that a gene variant common in Oceanian communities was misclassified as a potential cause of heart disease, highlighting the risk of the current diversity gap in genomics research which can pose a greater risk for misdiagnosis of people from non-European ancestries.

8 Mar 2025

Structural Insights into uMtCK Offer New Pathways for Targeting Cancer Energy Mechanisms

Cancer cells have an insatiable appetite for energy as they multiply more rapidly than normal cells. Greedy cancer cells hijack various cellular functions to find and exploit energy and other resources, including a group of enzymes that help normal cells maintain a balance of energy.

8 Mar 2025

DENND1B Gene Linked to Obesity in Dogs and Humans

Dogs are a compelling model of human obesity, in part because they develop obesity due to similar environmental influences as people.

8 Mar 2025

Tumor Cell Adhesion Could Help Predict Breast Cancer Spread

By assessing how "sticky" tumor cells are, researchers at the University of California San Diego have found a potential way to predict whether a patient's early-stage breast cancer is likely to spread.

6 Mar 2025

Neural Mechanism Involved in Leptin Resistance Revealed

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category.

5 Mar 2025

New Approach Could Protect Insulin-Producing Beta Cells from Damage Related to Diabetes

Researchers from the Icahn School of Medicine at Mount Sinai in New York have discovered a novel approach to protecting insulin-producing beta cells from the damaging effects of glucolipotoxicity-a harmful condition linked to the progression of type 2 diabetes (T2D).

5 Mar 2025

Study Clarifies Genetic Thresholds for Diagnosing SCA6

The Department of Neurology at Niigata University and National Center of Neurology and Psychiatry has identified pathogenic thresholds for the CAG repeat units (RU) of the CACNA1A gene that causes SCA6.

3 Mar 2025

Rare Gene Variants Increase Type 2 Diabetes Prevalence in Asian Indian Families

A new study published in Communications Medicine, a Nature publication, details the discovery of rare gene variants that increase the prevalence of Type 2 diabetes in multiple generations of Asian Indian people.

27 Feb 2025

Understanding Cell States Could Lead to More Personalized Leukemia Therapies

Myeloid leukaemias are among the most aggressive blood cancers and have low survival rates. Today, leukaemia patients undergo genetic analysis to identify mutations and select the most appropriate treatment.

26 Feb 2025

Natural Cytotoxic Agents Enhance Cancer Cell Susceptibility to Ferroptosis

One particular challenge in the treatment of cancer is therapy resistance. An international research team has now discovered a mechanism that opens up new treatment strategies for tumors in which conventional chemotherapeutic agents have reached their limits.

26 Feb 2025

RNA Splicing Errors May Hold the Key to Beating Gliomas Using Immunotherapy

Identifying splicing-related neoantigens in gliomas opens new avenues for immunotherapy, enhancing treatment strategies for this challenging brain tumor.

26 Feb 2025

New ctDNA Model Enhances Metastatic Cancer Surveillance

In metastatic cancer surveillance, monitoring the actual concentrations of circulating tumor DNA (ctDNA) may be critical. Researchers showed that absolute ctDNA concentration thresholds can be defined to rule out or predict impending cancer progression.

25 Feb 2025

Viking Skulls Show Evidence of Disease and Painful Conditions

Sweden's Viking Age population appears to have suffered from severe oral and maxillofacial disease, sinus and ear infections, osteoarthritis, and much more.

24 Feb 2025

Targeting NMDA Receptor Subunit Shows Promise for Fragile X Syndrome

Building on more than two decades of research, a study by MIT neuroscientists at The Picower Institute for Learning and Memory reports a new way to treat pathology and symptoms of fragile X syndrome, the most common genetically-caused autism spectrum disorder.

21 Feb 2025

Breakthrough mRNA Technology Paves the Way for Precision Medicine

Imagine a breakthrough in cancer treatment where only malignant cells are targeted, sparing healthy host cells; or patients with abnormal protein synthesis are treated to produce a healthy protein.

20 Feb 2025

Immunotherapy Breakthrough Targets Jumbled Proteins in Glioma

Immune therapy has transformed how cancer is treated, but many tumors continue to evade these treatments, thanks to their resemblance to healthy tissue.

20 Feb 2025

Dysfunctional Memory B Cells Identified as Key Cancer Therapy Target

University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center scientists have discovered a novel subset of cancer-fighting immune cells that reside outside of their normal neighborhood – known as the tertiary lymphoid structure – where they become frustratingly dysfunctional when in close contact with tumors.

20 Feb 2025