Molecular & Structural Biology

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RDP1 gene regulates the production of pollen grains

An international study has discovered a gene in the plant model Arabidopsis that reduces the number of pollen grains.

9 Jun 2020

Study reveals the relationship between genome folding and cellular functions

According to a study, the 3D structure of the human genome is fundamental to provide a quick and strong inflammatory response.

9 Jun 2020

Understanding protein-coding gene's role in IBD

A protein-coding gene associated with autoimmune diseases such as Crohn's disease and ulcerative colitis, collectively referred to as inflammatory bowel disease, or IBD, will be the focus of new research in the School of Medicine at the University of California, Riverside.

9 Jun 2020

Automated 3D brain imaging data analysis helps unravel complex neural circuits

Automated 3-D brain imaging data analysis technology offers more reliable and standardized analysis of the spatial organization of complex neural circuits.

9 Jun 2020

DNA damage and repair jointly shape mutational signatures

A collaborative project between the Center for Genome Integrity, within the Institute for Basic Science, and the Dundee School of Life Sciences, the EMBL's European Bioinformatics Institute, and the Wellcome Sanger Institute have screened almost 163,000 DNA mutations in 2,700 C. elegans roundworms to shed light on DNA damage.

9 Jun 2020

Genome rewiring could help explain evolution of multi-cellular organisms

InsideOutBio expert Dr Alan Herbert has explained a pioneering research in a paper recently published online by the Royal Society Open Science journal.

9 Jun 2020

A synthetic microbial system can determine location of origin for objects

Every year, an estimated 48 million Americans get sick from foodborne illnesses, resulting in some 128,000 hospitalizations and 3,000 deaths, according to the U.S. Centers for Disease Control and Prevention.

5 Jun 2020

Single-cell-resolution technologies help map brain regions in humans and primates

Using the single-cell-resolution transcriptomics technologies, researchers have performed a large-scale analysis of gene expression in 33 different brain regions of chimpanzees, bonobos, macaques, and humans, and successfully generated a map of the various brain regions with their particular cell structures.

5 Jun 2020

C19ORF57 gene could advance reproductive medicine

The gene C19ORF57 has been identified to play a major role in meiosis by the Institute of Molecular Embryology and Genetics at Kumamoto University.

5 Jun 2020

New image of LSD1 enzyme in action could provide insight into gene regulation

New images of an enzyme in action as it interacts with the chromosome could provide important insight into how cells--including cancer cells--regulate their genes.

5 Jun 2020

Human protein plays crucial role in transcription and genome integrity

Researchers from the University of Seville and Cabimer discover that the UAP56/DDX39B protein remove DNA-RNA hybrids from the genome.

5 Jun 2020

Researchers discover how a microRNA protects vascular integrity

Ludwig-Maximilian-Universitaet in Munich researchers have discovered a hitherto unknown molecular function of a specific microRNA that preserves integrity of the endothelium and reduces the risk of atherosclerosis.

5 Jun 2020

Exploring the cradle of hematopoietic stem cells

Researchers from the group of Catherine Robin at the Hubrecht Institute characterized the molecular landscape of the aorta that supports the generation of the first Hematopoietic Stem Cells (HSCs) in the embryo.

5 Jun 2020

Scientists aim to develop a gene-targeting, antiviral agent to combat COVID-19

A team of scientists from Stanford University is working with researchers at the Molecular Foundry, a nanoscience user facility located at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab), to develop a gene-targeting, antiviral agent against COVID-19.

5 Jun 2020

Salk researchers discover how cells remember their identity

Cancer is often the result of DNA mutations or problems with how cells divide, which can lead to cells "forgetting" what type of cell they are or how to function properly.

5 Jun 2020

Small protein has a great influence on bacterial gene regulation

Meningococci are bacteria that can cause life-threatening meningitis and sepsis. These pathogens use a small protein with a large impact: The RNA-binding protein ProQ is involved in the activation of more than 250 bacterial genes.

5 Jun 2020

Cryo-electron microscopy helps visualize PANX1 protein at near-atomic level

For the first time, researchers from Van Andel Institute have explained the near-atomic level structure of a molecular route that has crucial roles to play in the regulation of blood pressure, cell death, inflammation, and human development.

4 Jun 2020

Advanced microscopy techniques help visualize telomerase in living cells

Canadian researchers have made a major breakthrough in the analysis of telomerase, a crucial enzyme involved in cancer and aging.

4 Jun 2020

Study uncovers why developing nerve cells take a wrong turn

A group of scientists from CECAD, the Cluster of Excellence 'Cellular Stress Responses in Aging-Associated Diseases,' have found a mechanism by which neurodevelopmental diseases concerning neurons can be explained: The loss of a certain enzyme, UBE2K, impeded the differentiation of stem cells by silencing the expression of genes important for neuronal differentiation and, therefore, the development and generation of neurons.

4 Jun 2020

Building blocks of DNA and RNA could have co-existed in the primordial Earth

Scientists have long debated which genetic information carrier - DNA or RNA - started life on Earth, but a new study suggests life could have begun with a bit of both.

4 Jun 2020