Genetics and Genomics News and Research

Latest Genetics and Genomics News and Research

Mapping of Mouse Intestine Sheds Light on Immune Control and Adaptability

The intestine maintains a delicate balance in the body, absorbing nutrients and water while maintaining a healthy relationship with the gut microbiome, but this equilibrium is disrupted in parts of the intestine in conditions such as celiac disease, ulcerative colitis, and Crohn's disease.

22 Nov 2024

Chromosome Abnormalities Found in Healthy Women’s Breast Cells

A new study from researchers at The University of Texas MD Anderson Cancer Center finds that, in healthy women, some breast cells that otherwise appear normal may contain chromosome abnormalities typically associated with invasive breast cancer. The findings question conventional thinking on the genetic origins of breast cancer, which could influence early cancer detection methods.

22 Nov 2024

Researchers Map DNA Repair Protein Activity in Human Cells

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human cells.

22 Nov 2024

Versatile Molecule with a New Role in Genome Maintenance

A multi-institutional team of researchers from the Georgia Institute of Technology has uncovered a hitherto unidentified function for RNA.

22 Nov 2024

Immunotherapy Advances: CAR T Cells Targeting GD2 Offer Hope for Glioma Patients

Findings suggest GD2-specific CAR T-cell therapy is a viable option for H3K27M-mutant gliomas, with significant tumor shrinkage and clinical benefits observed.

22 Nov 2024

Scientists Map Microbiome of Rivers Across the U.S.

Rivers and streams serve as critical connectors across vast geographical landscapes, trickling out of tucked-away headwaters and snaking thousands of miles toward oceans and deep seas.

21 Nov 2024

Innovative Approach Reveals Brain Evolution Through Ancient DNA Methylation

This research introduces a novel method for inferring DNA methylation patterns in non-skeletal tissues from ancient specimens, providing new insights into human evolution.

21 Nov 2024

Ancient DNA Unlocks Secrets of European Genetic Adaptation

Leveraging a unique statistical analysis and applying it to ancient DNA extracted from human skeletal remains, a team of researchers from The University of Texas at Austin and the University of California, Los Angeles has revealed new insights into how ancient Europeans adapted to their environments over 7,000 years of European history.

21 Nov 2024

Discovery of Large Tandem Duplications Opens New Avenues for Cancer Treatment

Cancer researchers at the University of Chicago and the University of California, San Francisco (UCSF) have discovered that mutations in certain genes can lead to the accumulation of DNA errors, resulting in a specific type of genetic change known as large tandem duplications (TDs) that can arise from the collision of two critical cellular processes: transcription and DNA replication.

21 Nov 2024

Molecule Found to Aid Intestinal Healing and Prevent Tumor Growth in Colorectal Cancer

Researchers at Karolinska Institutet have found a molecule that can both help the intestines to heal after damage and suppress tumor growth in colorectal cancer.

21 Nov 2024

Novel Cellular Atlas of the Human Gastrointestinal Tract

Spatial and single-cell data from 1.6 million cells have been combined to produce the most complete cell map of the human stomach to date.

21 Nov 2024

Cancer-Causing Mutations Found in Healthy Breast Tissue

Williams, M. J., et al. (2024) Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations. Nature Genetics. doi.org/10.1038/s41588-024-01988-0.

21 Nov 2024

The Role of Social Networks in Shaping Gut Microbiome Diversity

In addition to having comparable interests, preferences, lifestyles, and other characteristics, friends can also have similar gut microbial compositions, according to a recent study led by Yale University.

21 Nov 2024

Sylph: A Fast and Accurate Tool for Species-Level Metagenome Profiling

Sylph's innovative approach to metagenome profiling delivers high accuracy and efficiency, advancing research in microbial diversity and disease associations.

21 Nov 2024

Novel Mechanism Revealed for Zygotic Genome Activation in Drosophila

Early development of an embryo is solely supported by maternally deposited RNAs and proteins until its own genome is activated through a process called zygotic genome activation (ZGA).

20 Nov 2024

Study Reveals Mystery Behind Extra Genes in Coronaviruses

Viruses are lean, mean, infection machines. Their genomes are tiny, usually limited to a handful of absolutely essential genes, and they shed extra genomic deadweight extremely fast.

20 Nov 2024

Scientists Use Cell Density to Control Tissue Formation

Genes aren't the sole driver instructing cells to build multicellular structures, tissues, and organs.

20 Nov 2024

How CRISPRi is Helping Combat Drug-Resistant Tuberculosis

Findings on isoniazid-resistant M. tuberculosis reveal key vulnerabilities, suggesting new avenues for treatment strategies against drug-resistant tuberculosis.

20 Nov 2024

Advanced Sequencing Uncovers Cause of Rare Mitochondrial Encephalopathy

Mitochondrial diseases are among the most prevalent hereditary metabolic disorders, known to occur in one out every 5000 births.

19 Nov 2024

Understanding Marine Worms’ Unique Ability to Regenerate Lost Body Parts

Many living organisms are able to regenerate damaged or lost tissue, but why some are particularly good at this and others are not is not fully understood.

19 Nov 2024