Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Innovative cancer therapy options with new cell death mechanism

Researchers from The University of Texas MD Anderson Cancer Center have described a previously unrecognized type of cell death called disulfidptosis in a study that was published in Nature Cell Biology.

7 Feb 2023

Gaining insights into human disease biology through CRISPR platforms

In this interview, we speak with Laralynne Przybyla about how she is utilizing CRISPR platforms to understand human disease biology in greater detail.

From Society for Laboratory Automation and Screening (SLAS) 7 Feb 2023

Researchers decipher how common environmental bacterium can digest complex waste

A common environmental bacterium, Comamonas testosteroni, could someday become nature's plastic recycling center.

7 Feb 2023

Study elucidates the structure of centromeric region in chicken cells

The genetic material inside cells is organized into structures called chromosomes. The centromere is essential for the correct division of the chromosomes via interaction with spindle microtubules when cells divide and grow.

7 Feb 2023

Newly discovered gene signature accurately predicts the functioning of P53 variants

In a paper published in PNAS, Maureen Murphy, Ph.D., Deputy Director of Wistar's Ellen and Ronald Caplan Cancer Center and Ira Brind Professor and Program Leader in the Molecular & Cellular Oncogenesis Program, and team have identified a gene signature that accurately predicts the functioning of P53 variants, important information to assessing cancer risk and optimizing choices for cancer therapeutics.

7 Feb 2023

Treating ovarian cancer with immunotherapy involving CAR T cells

Recent research revealed that CAR T-cell therapy, a particular type of cancer treatment in which the immune system’s T cells are directed to kill tumor cells, is successful in treating ovarian cancer in mice.

7 Feb 2023

Macrophages as new therapeutic target to address obesity-related diseases

Macrophages are immune system cells that control inflammation and tissue function in addition to being crucial in the early response to microbial infection. Since it aids in the repair of damaged tissue, inflammation is a natural physiological response.

6 Feb 2023

New hexameric structure of the protein triggering antibiotic resistance discovered

All living organisms require DNA replication to ensure the genetic integrity of the following generation. On the other hand, bacteria have the ability to horizontally transfer genetic information to other bacteria.

6 Feb 2023

Structure of amyloid fibers formed by the protein hnRNPDL-2 determined

Using high-resolution cryo-electron microscopy (cryo-EM), UAB researchers determined the structure of amyloid fibers formed by the protein hnRNPDL-2, which has been linked to limb-girdle muscular dystrophy type 3 and concluded that the protein’s inability to form amyloid ﬁbers, rather than aggregation, would be the cause of the disease.

6 Feb 2023

Researchers use AI to identify genes that are critical to a cancer cell’s survival

Researchers at the University of Sussex are using Artificial Intelligence (AI) technology to analyze different types of cancer cells to understand different gene dependencies, and to identify genes that are critical to a cell's survival.

6 Feb 2023

CAR T-cell therapy effective in mice with ovarian cancer

CAR T-cell therapy, a certain kind of cancer treatment in which the immune system's T cells are programmed to attack tumor cells, is effective in mice with ovarian cancer, according to a study published in The Journal for ImmunoTherapy of Cancer.

6 Feb 2023

Groundbreaking discovery could lead to new ways of controlling gene regulation

UT Southwestern Medical Center researchers have discovered a method cells use to turn genes on and off that involves portions of proteins whose function has long been a mystery.

6 Feb 2023

Antibody that blocks VEGF-B could be a potential therapeutic option for fatty liver disease

There is currently no drug for treating non-alcoholic fatty liver disease, which affects many people with type 2 diabetes and which can result in other serious liver diseases.

6 Feb 2023

Employing molecular anchor for more effective CAR immunotherapies

Researchers at St. Jude Children’s Research Hospital discovered that immune cells with the attached protein boosted the killing of cancer, irrespective of the kind of cancer cell or the type of cancer being targeted.

3 Feb 2023

Countering climate change with nanowires produced by bacteria

Rapid climate change poses a serious and immediate threat to life on Earth. As atmospheric methane traps heat 30 times more effectively than CO2, temperatures are rising as a result.

3 Feb 2023

Scientists unravel the physics of a cellular process linked to aggregation diseases

Researchers from Princeton University have uncovered the physics of a cellular process linked to aggregation diseases including Huntington's disease, paving the way to a deeper understanding of neurodegenerative disorders at the molecular level.

3 Feb 2023

Easy-to-use method quantifies exosomal miRNAs

Most cancer diagnostic procedures, like endoscopies, biopsies, and mammograms, are stressful and invasive. Although blood samples may be a less unpleasant option, only a few forms of the disease can as of now be diagnosed this way.

2 Feb 2023

Scientists define four cancer molecular subtypes using PDX models

Metastasis, the process by which cancer cells leave the primary tumor and spread to other tissues to seed new cancerous growth, causes most cancer deaths.

2 Feb 2023

Study uncovers a link between the genetic instructions for production and perception of sex pheromones

It's almost Valentine's Day, and love is in the air. Or in the waxy coating on your skin, if you are a vinegar fly. That's where flies encounter pheromones that play an important role in regulating sexual attraction.

1 Feb 2023

Study identifies genetic mutation in the SPTSSA gene as cause of Hereditary Spastic Paraplegia

A genetic mutation in the SPTSSA gene is identified as the cause of Hereditary Spastic Paraplegia, a rare disease that causes progressive weakness, stiffness and spasticity in the lower extremities, according to a study, "SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia," published in Brain on on Jan. 30.

1 Feb 2023

Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Innovative cancer therapy options with new cell death mechanism

Gaining insights into human disease biology through CRISPR platforms

Researchers decipher how common environmental bacterium can digest complex waste

Study elucidates the structure of centromeric region in chicken cells

Newly discovered gene signature accurately predicts the functioning of P53 variants

Treating ovarian cancer with immunotherapy involving CAR T cells

Macrophages as new therapeutic target to address obesity-related diseases

New hexameric structure of the protein triggering antibiotic resistance discovered

Structure of amyloid fibers formed by the protein hnRNPDL-2 determined

Researchers use AI to identify genes that are critical to a cancer cell’s survival

CAR T-cell therapy effective in mice with ovarian cancer

Groundbreaking discovery could lead to new ways of controlling gene regulation

Antibody that blocks VEGF-B could be a potential therapeutic option for fatty liver disease

Employing molecular anchor for more effective CAR immunotherapies

Countering climate change with nanowires produced by bacteria

Scientists unravel the physics of a cellular process linked to aggregation diseases

Easy-to-use method quantifies exosomal miRNAs

Scientists define four cancer molecular subtypes using PDX models

Study uncovers a link between the genetic instructions for production and perception of sex pheromones

Study identifies genetic mutation in the SPTSSA gene as cause of Hereditary Spastic Paraplegia

Omics eBook

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Omics eBook

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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