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Modified Nucleotides Boost saRNA Vaccine Efficacy and Protection Against SARS-CoV-2

Modified nucleotides like m5C in saRNA enhance vaccine efficacy, stability, and reduce inflammation, offering a promising approach for SARS-CoV-2 protection.

18 Sep 2024

One-Third of Antibody Drugs Show Unintended Target Binding

Integral Molecular, a leader in antibody discovery and characterization, has published new research in the journal mAbs, revealing that as many as one-third of antibody-based drugs exhibit nonspecific binding to unintended targets.

18 Sep 2024

Lipids Found to Play Key Role in Cancer Immune Evasion

Cancer cells seldom start off stealthy. Quite to the contrary, they announce their presence to the immune system by planting chemical red flags right on their membranes.

18 Sep 2024

Study Expands Potential of Retrons for DNA Editing

Within bacterial cells, specialized immune systems known as retrons fend off viral attacks. But that's not all they can do.

18 Sep 2024

Breakthrough Discovery on How TGF-Beta Communicates in Cells

Scientists discover how TGF-Beta, a crucial protein in development and cancer, sends its message even while tethered to the cell membrane.

17 Sep 2024

Using Optogenetic Control to Generate Leader Cells

In processes such as embryonic development, wound healing or cancer invasion, cells are known to move in groups in a coordinated way.

17 Sep 2024

New Insights into How Mutant p53 Promotes Tumor Growth

Research from the Federal University of Rio de Janeiro (UFRJ) and the National Institute of Science and Technology for Structural Biology and Bioimaging (INBEB) in Brazil has uncovered a critical mechanism by which mutations in the p53 protein-;a key tumor suppressor known as the "guardian of the genome"-;turn other proteins into cancer-promoting agents

17 Sep 2024

New Guidelines Enhance Accuracy of DNA-Protein Interaction Studies

Researchers at University of California San Diego have published new guidelines that could help scientists significantly improve their results when quantifying the interactions between DNA and proteins.

17 Sep 2024

PKN Inhibition Reduces Cardiac Fibrosis and Improves Heart Function

The number of people suffering from heart failure is rising quickly as society ages. Heart failure progression is linked to fibrosis, or the overgrowth of fibrotic tissue in the heart.

16 Sep 2024

New Guidelines for Accurate Spike-In Normalization in DNA-Protein Interaction Studies

New criteria developed by researchers at the University of California San Diego may greatly enhance the accuracy of results obtained by scientists when assessing the interactions between proteins and DNA.

16 Sep 2024

Membrane Tension and Calcium Signaling Regulate Phospholipid Scrambling

Researchers at the Institute for Integrated Cell-Material Sciences (WPI-iCeMS) at Kyoto University have discovered new information regarding how cells control the distribution of lipids in their cell membrane.

16 Sep 2024

Innovative Approach Supercharges T Cells by Transferring Healthy Mitochondria

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion.

16 Sep 2024

Research Sheds Light on Plant-Microbe Interactions and Auxin Hormone Effects

Gazing out on a freshwater pond, you may see tiny green plants with oval shaped leaves floating in clusters.

16 Sep 2024

CRISPR-Edited Euglena Offers Improved Biofuel Feedstock for Cold Conditions

News about biofuels sometimes mentions used cooking oil as a feedstock, but if these substances contain animal fat, they can solidify in colder temperatures.

16 Sep 2024

Potassium Isotope Ratios: A Potential Biomarker for Early Alzheimer's Disease Diagnosis

Potassium isotope ratios in serum show promise as biomarkers for Alzheimer's disease, revealing significant differences between patients and healthy controls.

16 Sep 2024

CHIEF Model Transforms Cancer Evaluation with Enhanced Generalizability Across Diverse Histopathology Samples

The CHIEF model revolutionizes cancer diagnosis, leveraging histopathological imaging to predict tumor origins and survival outcomes with exceptional accuracy.

16 Sep 2024

Soil pH Influences Microbial Community Formation and Nitrogen Cycling

Though a founding concept of ecology suggests that the physical environment determines where organisms can survive, modern scientists have suspected there is more to the story of how microbial communities form in the soil.

15 Sep 2024

Study Reveals How Alternative Splicing Regulates Plant Metabolite Production

A recent study highlights the pivotal role of alternative splicing in controlling plant secondary metabolism, which is crucial for producing bioactive compounds with significant medicinal and industrial value.

14 Sep 2024

Study Reveals Genetic Drivers Behind Red Pigmentation in Apple Flesh

A pivotal study has revealed the genetic drivers of red pigmentation in apple flesh, highlighting the critical role of anthocyanins and flavan-3-ols.

13 Sep 2024

New Protein Identified in Ferns Reveals Role in Plant Gender and Stem Cell Control

Purdue University plant scientists have identified a protein that plays a previously unknown role in controlling cell differentiation and determining gender in vascular plants, using a fern model.

13 Sep 2024