1. Mice lacking gamma-actin have normal hearing!
    James Ervasti James Ervasti United States says:
    March 31, 2025 at 9:48 AM

    Readers of this promotional piece should know that mice genetically modified to completely lack gamma-actin (the protein you’ve never heard of) have normal hearing. Here’s the reference:

    Sundby LJ, Hawbaker KM, Powers J, Southern WM, Johnson EE, Patrinostro X, Perrin BJ, Ervasti JM. The complete absence of cytoplasmic γ-actin results in no discernible phenotype in mice or primary fibroblasts. FEBS J. 2025 Mar 20. doi: 10.1111/febs.70075. Epub ahead of print. PMID: 40109120.

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