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Study discovers Parkinson’s disease-linked protein impairs mitochondria

Recently, researchers discovered that a protein linked with Parkinson’s disease can impair mitochondria.

23 Aug 2021

Study reveals the biology and treatment behind rare rheumatoid-like autoinflammatory condition

The absence of a protein that activates the body's antiviral defenses can cause a rare rheumatoid-like autoinflammatory condition that is treatable with an FDA-approved class of drugs known as TNF (tumor necrosis factor) inhibitors, a global research team led by Mount Sinai has found.

20 Aug 2021

Research provides a detailed 'proteogenomic' view of lung squamous cell carcinoma

Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, but the search for effective new therapies for another subtype called lung squamous cell carcinoma (LSCC) has largely come up short.

6 Aug 2021

Researchers identify inhibitor that converts immune cold cancer to red hot ones

Scientists headed by the University of Michigan Rogel Cancer Center converted an immune cold cancer into one that responds to immunotherapy.

4 Aug 2021

New study could help develop novel treatments for neurodegenerative diseases

Researchers have introduced a novel gene therapy program that could set the stage for new treatments for neurodegenerative diseases.

2 Aug 2021

Analyses of DNA tags may lead to better understanding of treatment approaches for cancers

Cell-free DNA (cfDNA) shed into the blood was discovered in the late 1940s but with rapid advances in genomics and computational analytics in just the past few years, researchers at Georgetown Lombardi Comprehensive Cancer Center now believe that studying tags, or modifications to this type of DNA, may lead to a better understanding of how to assess, and possibly modulate, treatment approaches for cancer and other diseases.

28 Jul 2021

Yeast study reveals a protein involved in gross chromosomal rearrangements

Gross chromosomal rearrangements--where portions of the genome become moved, deleted, or inverted--can lead to cell death and diseases such as cancer in complex multicellular organisms.

23 Jul 2021

Study unravels the biomechanical, biophysical response of cancer cells to drugs

A new study reports the use of single-cell, force spectroscopy methods to probe biophysical and biomechanical kinetics of cancer cells.

21 Jul 2021

Atomic force spectroscopy probes cellular biomechanics in response to drugs in hypoxia

Oncotarget published "Dynamic cellular biomechanics in responses to chemotherapeutic drug in hypoxia probed by atomic force spectroscopy" which reported that by exploiting single-cell, force spectroscopy methods, the authors probed biophysical and biomechanical kinetics of brain, breast, prostate, and pancreatic cancer cells with standard chemotherapeutic drugs in normoxia and hypoxia over 12-24 hours.

20 Jul 2021

World’s first cancer cell model helps modern cancer research and drug development

For many years, computer models have been standard tools in fundamental biomedical research.

5 Jul 2021

WEHI partners with Boehringer Ingelheim to develop novel anti-cancer therapeutics

WEHI has partnered with Boehringer Ingelheim, a leading research-driven pharmaceutical company, in a collaboration to discover and develop anti-cancer therapeutics using a promising new technology called targeted protein degradation.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 25 Jun 2021

Protein known to mediate cell death plays a key role in maturation and release of interleukin-1α

Interluekin-1α (IL-1α) is an important part of the immune response, but until now it has been unclear how this molecule is processed from its precursor, pro-IL-1α, and exits the cell during inflammasome activation.

21 Jun 2021

Inhibition of necroptosis may be a new therapeutic approach to treating COPD

Research shows that inhibiting necroptosis, a form of cell death, could be a novel therapeutic approach for treating chronic obstructive pulmonary disease (COPD), an inflammatory lung condition, also known as emphysema, that makes it difficult to breathe.

21 Jun 2021

Scientists unravel the proteins that trigger some cancerous tumors

Even on a good day, DNA is constantly getting damaged. Nicks, scratches, breaks: the delicate strands that carry life's genetic code take a beating as they jumble about in the course of their work. If left untreated, errors accumulate, with fatal consequences -- such as cancerous tumors -- for the cell and the organism.

11 Jun 2021

Novel protein could improve treatment outcomes after heart attacks

New research, headed by scientists from Washington State University, has revealed a protein that could be crucial for enhancing treatments after a heart attack.

4 Jun 2021

Scientists discover the central role of LRRC8A gene in cellular ability to survive osmotic shock

Cells have to constantly adapt to their surroundings in order to survive. A sudden increase in the environmental levels of an osmolyte, such as salt, causes cells to lose water and shrink. In a matter of seconds, they activate a mechanism that allows them to recover their initial water volume and avoid dying.

2 Jun 2021

Cell Death News and Research

Study discovers Parkinson’s disease-linked protein impairs mitochondria

Study reveals the biology and treatment behind rare rheumatoid-like autoinflammatory condition

Research provides a detailed 'proteogenomic' view of lung squamous cell carcinoma

Researchers identify inhibitor that converts immune cold cancer to red hot ones

New study could help develop novel treatments for neurodegenerative diseases

Analyses of DNA tags may lead to better understanding of treatment approaches for cancers

Yeast study reveals a protein involved in gross chromosomal rearrangements

Study unravels the biomechanical, biophysical response of cancer cells to drugs

Atomic force spectroscopy probes cellular biomechanics in response to drugs in hypoxia

World’s first cancer cell model helps modern cancer research and drug development

WEHI partners with Boehringer Ingelheim to develop novel anti-cancer therapeutics

Protein known to mediate cell death plays a key role in maturation and release of interleukin-1α

Inhibition of necroptosis may be a new therapeutic approach to treating COPD

Scientists unravel the proteins that trigger some cancerous tumors

Novel protein could improve treatment outcomes after heart attacks

Scientists discover the central role of LRRC8A gene in cellular ability to survive osmotic shock

Study discovers novel function for metabolic enzyme medium-chain acyl-CoA dehydrogenase

Exposure to even low levels of lead can trigger epigenetic changes

Study analyzes how resistance proteins defend plants from pathogens

Study reveals mitochondrial enzyme plays a vital role in preventing ferroptosis

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