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A new way to predict positive outcomes of immunotherapy in patients with bladder cancer

Researchers have detected and validated groups of genes linked to immunotherapy resistance in patients with metastatic urothelial cancer of the bladder.

12 Apr 2021

Women may be at a greater risk of experiencing chronic pain than men

According to a new study, women may be facing a higher risk of feeling chronic pain since the condition has a different genetic basis in men and women.

9 Apr 2021

Mitochondrial DNA mutations reduce death risk in patients with bowel cancer

According to a study, DNA defects in the energy “factories” of a cell increase the chance of survival in patients suffering from bowel cancer.

9 Apr 2021

Inhibiting a specific protein could increase tumor sensitivity to PARP inhibitors

Researchers at the Francis Crick Institute have found that blocking a specific protein could increase tumor sensitivity to treatment with PARP inhibitors. Their work published in Science , suggests combining treatments could lead to improved therapy for patients with inheritable breast cancers.

9 Apr 2021

Genomes of earliest Europeans and their association with Neanderthals

An international research team has sequenced the genomes of the oldest securely dated modern humans in Europe who lived around 45,000 years ago in Bacho Kiro Cave, Bulgaria.

8 Apr 2021

New technique improves single-cell transcriptomics

With the help of single-cell transcriptomic techniques, researchers can study an unlimited number of individual cells from living organisms one at a time.

8 Apr 2021

PNA-based method is a key component of the gene editing toolkit

The Somatic Cell Gene Editing Consortium has given an update on the status of their initiative to design safer techniques to edit the genes of disease-relevant somatic cells.

8 Apr 2021

Warped immune cell signaling during bile acid exposure may lead to Crohn’s disease

People with Crohn's disease are typically treated with powerful anti-inflammatory medications that act throughout their body, not just in their digestive tract, creating the potential for unintended, and often serious, side effects.

8 Apr 2021

Discovery of heat-sensing gene could help crops to cope better with climate change

By 2050 global warming could reduce crop yields by one-third. UC Riverside researchers have identified a gene that could put the genie back in the bottle.

7 Apr 2021

Scientists discover mutations that make cancer resistant to KRAS-targeted therapies

A gene called KRAS is one of the most commonly mutated genes in all human cancers, and targeted drugs that inhibit the protein expressed by mutated KRAS have shown promising results in clinical trials, with potential approvals by the U.S. Food and Drug Administration anticipated later this year.

7 Apr 2021

Japanese consumers have more negative opinions about gene-editing of livestock, survey finds

A statistically rigorous survey of Japanese consumers has found that they have more negative opinions about the use of new gene-editing techniques on livestock than they do about use of the same technologies on vegetables.

7 Apr 2021

Genetic makeup of more than 53,000 people offers valuable insights into dangerous diseases

A new analysis of the entire genetic makeup of more than 53,000 people offers a bonanza of valuable insights into heart, lung, blood and sleep disorders, paving the way for new and better ways to treat and prevent some of the most common causes of disability and death.

7 Apr 2021

Researchers identify overlapping genetic locations that shape face and the brain

An interdisciplinary team led by KU Leuven and Stanford has identified 76 overlapping genetic locations that shape both our face and our brain.

6 Apr 2021

Tumor-inhibiting protein p53 boosts gene expression by bringing together nuclear speckles and DNA

Scientists at the University of Pennsylvania headed a group of researchers to unravel the functions of the so-called “nuclear speckles”.

6 Apr 2021

New CRISPR-SNP-Chip technology detects single-point mutations without amplification

The CRISPR-Chip technology was first introduced in 2019 by Dr. Kiana Aran, an Assistant Professor at Keck Graduate Institute (KGI).

6 Apr 2021

Study identifies multiple genes that are frequently mutated in uterine leiomyosarcomas

In a new study, Yale Cancer Center researchers have defined the genetic landscape of uterine leiomyosarcomas (uLMS).

6 Apr 2021

Researchers use single-cell RNA sequencing to study the development of leaves

How do we become a complex, integrated multicellular organism from a single cell? While developmental biologists have long researched this fundamental question, Stanford University biologist and HHMI investigator Dominique Bergmann's recent work on the plant Arabidopsis thaliana has uncovered surprising answers.

6 Apr 2021

Novel cell-to-cell communication network helps cancers regrow following genotoxic therapies

In the fight against cancers, activating mutations in the RAS family of genes stand in the way of finding viable treatment options.

6 Apr 2021

High expression of cell death genes linked to increased risk of dying early from lung cancer

Patients with a high number of genes most associated with pathways that lead to cell death in lung cancer are at increased risk of dying early from their disease, researchers report.

6 Apr 2021

Customized tumor cell vaccine produces active immune response in melanoma, neuroblastoma models

A pre-clinical study for melanoma and neuroblastoma shows that a customized tumor cell vaccine technique that targets Myc oncogenes coupled with checkpoint therapy produces an active immune response that bypasses antigen selection and immune privilege.

5 Apr 2021

Genes News and Research

A new way to predict positive outcomes of immunotherapy in patients with bladder cancer

Women may be at a greater risk of experiencing chronic pain than men

Mitochondrial DNA mutations reduce death risk in patients with bowel cancer

Inhibiting a specific protein could increase tumor sensitivity to PARP inhibitors

Genomes of earliest Europeans and their association with Neanderthals

New technique improves single-cell transcriptomics

PNA-based method is a key component of the gene editing toolkit

Warped immune cell signaling during bile acid exposure may lead to Crohn’s disease

Discovery of heat-sensing gene could help crops to cope better with climate change

Scientists discover mutations that make cancer resistant to KRAS-targeted therapies

Japanese consumers have more negative opinions about gene-editing of livestock, survey finds

Genetic makeup of more than 53,000 people offers valuable insights into dangerous diseases

Researchers identify overlapping genetic locations that shape face and the brain

Tumor-inhibiting protein p53 boosts gene expression by bringing together nuclear speckles and DNA

New CRISPR-SNP-Chip technology detects single-point mutations without amplification

Study identifies multiple genes that are frequently mutated in uterine leiomyosarcomas

Researchers use single-cell RNA sequencing to study the development of leaves

Novel cell-to-cell communication network helps cancers regrow following genotoxic therapies

High expression of cell death genes linked to increased risk of dying early from lung cancer

Customized tumor cell vaccine produces active immune response in melanoma, neuroblastoma models

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