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A gene is a unit of heredity in a living organism. It normally resides on a stretch of DNA that codes for a type of protein or for an RNA chain that has a function in the organism. All living things depend on genes, as they specify all proteins and functional RNA chains.

Exploring cell and gene based therapies for Parkinson’s disease

After several decades of pre-clinical development, cell- and gene-based therapies for Parkinson's disease (PD) are now actively being explored. In this special supplement to the Journal of Parkinson's Disease on "Repairing the Parkinsonian Brain," experts highlight some of the current strategies being pursued to restore lost function and replace what is lost in the PD brain, with special emphasis on the challenges associated with translating advanced therapeutic approaches into pioneering clinical trials.

24 Sep 2021

Researchers identify host entry factor for Rift Valley fever virus

Rift Valley fever virus causes economically devastating outbreaks of hemorrhagic fever in livestock such as sheep, goats and cattle. These mosquito-borne outbreaks lead to infection in people working with dead or dying animals, sometimes causing hundreds of human cases and dozens of deaths.

24 Sep 2021

Scientists analyze the molecular machinery of poxviruses at an atomic level

Poxviruses have found a unique way of translating their genes into proteins in the infected organism. A team of researchers from Würzburg shows for the first time how the molecular machinery involved works at an atomic level.

24 Sep 2021

How do genetic variants influence the expression of genes in the blood?

Researchers are now pursuing intensive research on the genetic causes of traits and diseases, with over 250,000 such links known currently.

24 Sep 2021

How does the KLF4 transcription factor influence gene expression?

Scientists have led a research group to identify a mechanism using which transcription factor KLF4 can influence gene expression.

24 Sep 2021

Researchers reverse Kleefstra syndrome after birth in a mouse model

Scientists announced the reversal of Kleefstra syndrome—a genetic disorder leading to intellectual disability.

23 Sep 2021

Researchers provide novel treatment target for common skin condition

Recent research indicates that a familiar inflammatory skin condition might arise due to inadequately regulated sex hormones.

23 Sep 2021

Genetic and epigenetic origin of pediatric liver cancer uncovered

Researchers at Hiroshima University have analyzed the molecular findings of almost 160 pediatric liver cancer cases and discovered molecular markers that should help to understand and treat the considerable variation in prognoses.

22 Sep 2021

Researchers seek to point a way toward a unified theory for DNA folding

At more than 2 meters long, the human DNA molecule uses intricate folding patterns to fit into cells while locally unfolding to express genes. Such phenomena, however, are difficult to measure in experiments, and theoretical frameworks explaining them continue to be at odds with one another.

22 Sep 2021

Scientists find two proteins that pair up to build lifelines to cancer cells

In human cancer cell and mouse studies, researchers from Johns Hopkins Medicine have found that a set of proteins work in tandem to build supply lines that deliver oxygen and nutrients to tumors, enabling them to survive and grow.

21 Sep 2021

Study outlines the advantages of organoids for basic research into coronaviruses

Scientists created an organoid biobank to investigate the genes that are vital for the spreading of a SARS-CoV-2 infection.

21 Sep 2021

Researchers identify a manipulation molecule produced by bacteria to hijack plant development

A newly discovered manipulation mechanism used by parasitic bacteria to slow down plant aging, may offer new ways to protect disease-threatened food crops.

20 Sep 2021

Study reveals how the tumor suppressor gene plays a vital role in pediatric rhabdomyosarcoma

Scientists at St. Jude Children's Research Hospital have revealed how the tumor suppressor gene PTEN plays a more important role in pediatric rhabdomyosarcoma than was previously appreciated.

20 Sep 2021

Novel T cells reside in lymph nodes and offer protection against melanoma

Immunotherapy is an advancing field but there is limited knowledge on the immunity to metastatic tumors in locations like lymph nodes.

20 Sep 2021

Changes in epigenome responsible for reduced stem cell function upon aging

The bones become thinner with age, resulting in frequent fractures and making them susceptible to bone diseases like osteoporosis.

From The Max Planck Institute 20 Sep 2021

Study identifies vital factor involved in the evolution of the human brain

Humans have a huge and intricately folded neocortex, the reason for various intellectual abilities, setting apart humans from all other species.

17 Sep 2021

Hundreds of mutated tumor suppressor genes can help cancer cells evade the immune system

Hundreds of cancer-linked genes play a different role in causing disease than scientists had expected.

17 Sep 2021

UC Riverside scientists aim to turn edible plants into mRNA vaccine factories

The future of vaccines may look more like eating a salad than getting a shot in the arm. UC Riverside scientists are studying whether they can turn edible plants like lettuce into mRNA vaccine factories.

17 Sep 2021

Researchers capture the assembly of ribosomes within human cells

Ribosomes are the multi-component molecular machines that create complex proteins by binding building blocks together as per instructions encoded in the messenger RNAs of the cell.

16 Sep 2021

New genetic classifier can predict the sensitivity of chemotherapy for breast cancer

A team of researchers recently postulated a genetic classifier with the ability to predict the sensitivity of neoadjuvant chemotherapy for breast cancer in the area of tumor molecular markers.

16 Sep 2021