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A gene is a unit of heredity in a living organism. It normally resides on a stretch of DNA that codes for a type of protein or for an RNA chain that has a function in the organism. All living things depend on genes, as they specify all proteins and functional RNA chains.

Study Reveals Widespread Gene Misbehavior in Healthy Humans

Scientists have uncovered that ‘gene misbehaviour’ – where genes are active when they were expected to be switched off – is a surprisingly common phenomenon in the healthy human population.

29 Jul 2024

Effective Plasmid DNA Delivery Achieved with Zwitterionic Polymer Complex

Researchers from Tokyo Metropolitan University have created a new drug delivering molecule, a zwitterionic polymer complex that can help get plasmid DNA inside cells when injected into skeletal muscle, a crucial step in the expression of therapeutic RNA and proteins. The new compound effectively bound to plasmid DNA without affecting its structure. Injected into mouse muscles, the team observed widespread gene expression, promising applications to treatments of serious muscle diseases.

29 Jul 2024

Specific Genes May Determine Stroke Recovery Path

New research led by UCLA Health has found that specific genes may be related to the trajectory of recovery for stroke survivors, providing doctors insights useful for developing targeted therapies.

29 Jul 2024

New Gene Therapy Approach Improves Muscle Strength in DMD Mice

Indiana University School of Medicine researchers have made a significant breakthrough in developing a new gene therapy approach that restores full-length dystrophin protein, which could lead to new treatments for people with Duchenne muscular dystrophy (DMD).

29 Jul 2024

Plant-Based Diet Slows Down Biological Aging Markers

Eating a vegan diet for eight weeks is associated with reductions in biological age estimations based on levels of DNA methylation -; a type of chemical modification of DNA (known as an epigenetic modification) that alters gene expression but not DNA itself. Previous research has reported that increased DNA methylation levels are associated with aging. The findings, which are based on a small randomized controlled trial of 21 pairs of adult identical twins, are published in BMC Medicine.

29 Jul 2024

Unraveling the Complexities of X Chromosome Inheritance

A new study published in Nature Genetics by the Lymphoid Development Group at the MRC Laboratory of Medical Sciences has reveals that the contribution of cells expressing maternal or paternal X chromosomes can be selectively skewed in different parts of the body.

26 Jul 2024

Cost-Effective Array Sheds Light on Imprinted Gene Regulation

Researchers from North Carolina State University have developed an array that assesses methylation levels of genes located in imprint control regions (ICRs) within the human genome. The array represents a cost-effective, efficient method for exploring potential links between environmental exposures and epigenetic dysregulation during the early developmental origins of diseases and behavioral disorders.

26 Jul 2024

New Insights into the Mechanisms of Gene Misbehavior

Researchers have discovered that a startlingly widespread occurrence in the healthy human population is "gene misbehavior," or the state in which genes are active when they should be inactive.

25 Jul 2024

DNA Sequence Variants Drive Link Between Methylation and Gene Expression

The relationship between DNA methylation and gene expression is driven by sequence variants, according to a recent study conducted by researchers at deCODE Genetics, an Amgen subsidiary.

25 Jul 2024

Traffic-Related Ultrafine Particles Cause Mitochondrial Dysfunction in Olfactory Mucosa

Ultrafine particles, UFPs, the smallest contributors to air pollution, hinder the function of mitochondria in human olfactory mucosa cells, a new study shows.

25 Jul 2024

NanoRanger Offers Rapid, Precise Diagnosis for Genetic Diseases

An effective long-read sequencing method that looks for intricate genomic variations can quickly and accurately diagnose genetic disorders molecularly.

24 Jul 2024

New Tool GeneMAP Unveils Key Insights into Cell Metabolism

There's a glaring gap in our knowledge of cell metabolism: in many cases, we still don't know exactly how nutrients are transported into the cell.

24 Jul 2024

New RNA Sequencing Dataset Reveals Genetic Diversity Across Global Populations

An open-access dataset of RNA sequences from lymphoblastoid cell lines of 731 individuals spanning 26 populations and five continental groups.

24 Jul 2024

RNA Technology Enables Precise Control of Gene Networks

Scientists have created a smart RNA that can control networks in response to different signals by converting guide RNAs, which normally direct enzymes. The scholarly community is paying close attention to this ground-breaking study.

23 Jul 2024

Study Identifies Microproteins as Key Source of Tumor-Specific Antigens in Liver Cancer

If microproteins translated from noncanonical open reading frames (ncORFS) in long noncoding ribonucleic acids (RNAs) could be a potential source of tumor-specific antigens.

23 Jul 2024

Developing DNA Test to Eliminate Inherited Blindness in English Shepherd Dogs

Researchers at Cambridge have discovered the genetic mutation that causes English Shepherd Dogs to suffer from progressive retinal atrophy, an irreversible form of blindness.

22 Jul 2024

Genomic Insights into Prunus Species Evolution and Traits

The Prunus genus, encompassing apricots, peaches, plums, and mei, is vital due to its economic and nutritional value.

22 Jul 2024

Rhythmic Gene Expression Regulates Root Nodule Formation in Legumes

Legumes thrive in low-nitrogen environments by partnering with rhizobia, soil bacteria that convert atmospheric nitrogen into ammonium, a usable form for the plants.

22 Jul 2024

Ginseng Genome Map Unlocks New Possibilities for Medicinal Applications

A landmark study has successfully decoded the complete ginseng genome, unveiling the genetic mechanisms that govern saponin biosynthesis. This detailed genetic map illuminates the evolutionary and metabolic pathways of Panax ginseng, a staple in traditional medicine.

19 Jul 2024

Global Gene Expression Data Improves Precision in Genetics

The majority of human genetics research has traditionally concentrated on individuals with European ancestry, a long-standing bias that may reduce the precision of scientific predictions for individuals from other populations.

18 Jul 2024