therapeutics News and Research

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cBAF Protein Complex Controls the Fate of T Cells

The immune system protects the body from intruders, like bacteria, viruses, or tumors, with its intricate network of proteins, cells, and organs. Cytotoxic T cells are specialized immune cells that can grow into short-lived effector cells that destroy infected or malignant cells in human bodies.

14 Jun 2023

Reengineering the Cellular Synthetic Machinery to Produce Never-Before-Seen Polymers

Synthetic biologists have become increasingly creative in engineering yeast or bacteria to churn out useful chemicals -; from fuels to fabrics and drugs -; beyond the normal repertoire of microbes.

14 Jun 2023

Virus Plays Important Role in Treating Glioblastoma

A potential advancement in the treatment of glioblastoma was noted by Howard Colman, MD, PhD, the Jon M. Huntsman Presidential Professor of Neuro-Oncology and co-leader of the Neurologic Cancers Disease Center and the Experimental Therapeutics CCSG program at Huntsman Cancer Institute, in a recently published manuscript.

13 Jun 2023

Researchers Discover Novel Combination Therapy to Counter Antibiotic-resistant Mycobacterium Abscessus Infections

Researchers from the Antimicrobial Resistance (AMR) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, in collaboration with Nanyang Technological University Singapore (NTU Singapore) and National University Hospital (NUH), have discovered a novel therapy by combining two antibiotics, rifaximin and clarithromycin, to treat Mycobacterium abscessus (M. abscessus), a non-tuberculous mycobacterium (NTM) that causes chronic lung-related infections.

9 Jun 2023

The New Player in ALS—An Ancient, Virus-Like Protein

ALS (amyotrophic lateral sclerosis) is a deadly neurodegenerative disease that attacks nerve cells in the brain and spinal cord, progressively robbing individuals of their capability to speak, move, eat, and breathe.

8 Jun 2023

Scientists Integrate Multiple Therapeutic Approaches to More Effectively Target Brain Metastatic Melanomas

Acting as a team, twin stem cells activate the immune system to suppress tumor growth and prolong survival in representative preclinical models.

1 Jun 2023

Researchers Develop Novel Metal-Protein Hybrid Complex With Enhanced ROS Activity

Cu(II) complexes with low molecular weight are functional superoxide-dismutase (SOD) models with superior reactive oxygen species (ROS) removal ability.

30 May 2023

Ex Vivo Expansion of HSCs Using a Novel Culture System

Hematopoietic stem cells (HSCs) are immature blood cells found in the bone marrow that can be stimulated to develop into any type of blood cell.

25 May 2023

Breakthrough Discovery Paves Way for Understanding Downstream Cellular Applications in Human Health

Assemblies of tiny molecular proteins span the membranes that encapsulate our cells, directing cellular activities and regulating the transport of materials and information in and out.

25 May 2023

Novel Map Depicts the Human Body's Highly Complicated System for Repairing DNA Damage

Writing in the May 22, 2023 issue of Cell Systems, a diverse team of scientists, led by researchers at University of California San Diego School of Medicine, have produced a novel map that depicts the human body's enormously complicated and highly evolved system for addressing and repairing DNA damage -; a cause and consequence of many diseases.

23 May 2023

Altered Anti-Nausea Drug can Penetrate Cells and Provide Sustained Pain Relief

Altering the chemical properties of an anti-nausea drug enables it to enter an interior compartment of the cell and provide long-lasting pain relief, according to a new study led by researchers at NYU College of Dentistry's Pain Research Center.

23 May 2023

A High-Throughput Assay for Identifying and Validating ECHS1 Enzyme Genetic Variants

The enzyme variations of mitochondrial enoyl-CoA hydratase short-chain 1 (ECHS1) are dysfunctional. In Japan, they are mostly responsible for mitochondrial disease.

19 May 2023

Pancreatic Cancer Cells Use a New Nutrient Source to Grow, Study Finds

Researchers at the University of Michigan Rogel Cancer Center have discovered a new nutrient source that pancreatic cancer cells use to grow.

18 May 2023

Understanding How Cell-to-Cell Communication Networks Drive Pancreatic Cancer Development

Discussions of cancer often stress the genetic mutations that drive disease by altering the normal function of cellular proteins.

12 May 2023

Cytiva and Pall Life Sciences Complete Integration to Create a Global Innovation and Solutions Leader in Biotechnology

Cytiva and the life sciences business of Pall Corporation have completed their integration and are now united as one business under the Cytiva brand.

12 May 2023

Breakthrough "Gene Silencing" Technology Could Revolutionize the Development of DNAzymes

Researchers from the University of California, Irvine have developed a DNA enzyme – or DNAzyme – that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact.

9 May 2023

T Cells can Fuel Their Ability to Attack Tumors

When you need a bit of motivation, it often has to come from within. New research suggests cancer-fighting immune cells have found a way to do just that.

9 May 2023

Cancer Stem Cell Test can Accurately Decide More Effective Treatments for Glioblastoma Patients

New multi-institutional phase 3 clinical trial data published May 2 in Cell Reports Medicine found that a cancer stem cell test can accurately decide more effective treatments and lead to increased survival for patients with glioblastoma, a deadly brain tumor.

8 May 2023

Researchers Create a Computational Tool to Gain New Insights From Multi-Omics Data

Despite the astounding advances made in understanding the biologic underpinnings of cancer, many cancers are missing obvious genetic drivers.

5 May 2023

Study Reveals an Immunological Strategy to Overcome Microbiome-Related Immunotherapy Resistance

Cancer immunotherapy has transformed the treatment of many types of cancer. Yet, for reasons that remain poorly understood, not all patients get the same benefit from these powerful therapies.

4 May 2023