Genetic News and Research

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Phage-Derived Endolysin Offers Targeted Treatment for Dysbiosis-Driven Acute GVHD

Allogenic hematopoietic cell transplantation (allo-HCT) involves transferring healthy donor stem cells to recipients with conditions like blood cancer, bone marrow failure, or certain genetic blood disorders.

11 Jul 2024

UNC-Chapel Hill Study Reveals New Mechanism of Gene Regulation Beyond Histone Modification

University of North Carolina at Chapel Hill researchers have determined whether a specific chemical modification of a protein that packages the genome called a histone affects gene activity and cell proliferation according to the paper, "Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation," published in Genes & Development.

11 Jul 2024

Retron-Based Tool Enables Multi-Site DNA Editing

Genome editing has become a widely adopted technology to modify DNA in cells, allowing scientists to study diseases in the lab and develop therapies that repair disease-causing mutations.

10 Jul 2024

Unveiling the Power of mRNA and LNPs in Modern Medicine

Consider a situation in which an expert hacker has to upload vital software to update a central server and stop a potentially fatal virus from causing havoc on a sizable computer network.

10 Jul 2024

A New Tool to Unravel the Mysteries of Metabolic Genes

A novel discovery platform has been created by a multidisciplinary research team to investigate the role of genes involved in metabolism, which is the culmination of all chemical reactions necessary for life.

9 Jul 2024

Integrating Genomic Data for Enhanced Fruit Tree Breeding

Genotyping techniques can be used to select fruit trees with desired traits at the seedling stage, increasing the efficiency of fruit tree breeding.

8 Jul 2024

Comprehensive Analysis Identifies Risk Factors for Multiple Cancers

Scientists have discovered over 5,000 genetic variations that give rise to specific cancers, along with a possible therapeutic target that could be used to treat or even stop these cancers from growing.

8 Jul 2024

Scientists develop first fully functional human immune system in mouse model

Researchers at The University of Texas Health Science Center in San Antonio have produced a mouse model that is humanized, complete with a human immune system and a gut microbiome that resembles that of a human being and is able to elicit particular antibody responses.

8 Jul 2024

Selfish No More: Genetic Elements Give Phages a Competitive Edge

Curious bits of DNA tucked inside genomes across all kingdoms of life historically have been disregarded since they don't seem to have a role to play in the competition for survival.

7 Jul 2024

Study Reveals Key Genetic Interaction for Enhanced Drought Tolerance in Plants

Drought significantly impacts agricultural productivity and plant survival. Traditional methods for improving drought resistance, such as selective breeding and genetic modification, have had limited success.

5 Jul 2024

New Genetic Circuit Forces Cancer Cells to Self-Destruct

Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving them one step behind.

5 Jul 2024

Bowel Cancer Cells Use Genetic On-Off Switch' to Evade the Immune System

Bowel cancer cells have the ability to regulate their growth using a genetic on-off switch to maximize their chances of survival, a phenomenon that's been observed for the first time by researchers at UCL and University Medical Center Utrecht.

4 Jul 2024

Pasteurization Effectively Eliminates H5N1 Virus from Milk

In March 2024, dairy cows in Texas were found to be infected with highly pathogenic avian flu, or H5N1 bird flu, in the first known case of the virus spreading to cattle.

4 Jul 2024

Using Mobile Data to Track the Spread and Evolution of Superbugs

Key insights into the global spread, evolution, and resistance patterns of a major bacterium causing pneumonia and meningitis have been revealed through the combination of genomic data and human travel patterns over 14 years in South Africa.

4 Jul 2024

Innovative Approach to Protein Synthesis Funded by $2 Million Grant

The National Institutes of Health's Maximizing Investigators' Research Award (MIRA) program for established investigators has awarded Rice University chemist Han Xiao with nearly $2 million.

4 Jul 2024

Researchers Decode Impact of Every Possible Alteration in Critical Cancer Gene

Scientists at the Francis Crick Institute have mapped all possible outcomes of changes to a tumor-suppressing gene called VHL, as the first step in a massive research project to unravel the consequences of tens of thousands of genetic variations in genes linked to cancer.

4 Jul 2024

TRPC5 Gene Alterations: A Key Player in Obesity and Postpartum Depression

Researchers at Baylor College of Medicine, the University of Cambridge and collaborating institutions have discovered that alterations in the human gene TRPC5 cause obesity and postpartum depression.

3 Jul 2024

Small Molecules Offer Precise Control Over Splicing in Gene Expression

The correct functioning of cells relies heavily on the ability to finely control gene expression, a complex process by which the information contained in DNA is copied into RNA to eventually give rise to all the proteins and most of the regulatory molecules in the cell.

3 Jul 2024