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Researchers identify the cause for Parkinson's disease and potential treatments

Researchers identify the cause for Parkinson's disease and potential treatments

In a seven-year research effort, an international team of scientists has clarified the cause for certain genetic forms of Parkinson's disease, and has identified potential pharmacological treatments.

14 Sep 2020

Inherited variation in GATA3 gene associated with relapse in children with leukemia

Inherited variation in GATA3 gene associated with relapse in children with leukemia

Scientists at St. Jude Children's Research Hospital are investigating the inherited genetics of childhood leukemia and how particular gene variations can affect treatment outcomes. The research showed that an inherited variation in the GATA3 gene strongly influences early response to chemotherapy and is linked to relapse in children with acute lymphoblastic leukemia (ALL).

14 Sep 2020

New study can help develop diagnostic markers for type 2 diabetes

New study can help develop diagnostic markers for type 2 diabetes

Scientists can detect changes in the islets of Langerhans of the pancreas in patients several years before these individuals are diagnosed with type 2 diabetes.

14 Sep 2020

Study shows how genetic variants affect gene regulation and contribute to disease risk

Study shows how genetic variants affect gene regulation and contribute to disease risk

The multi-institutional Genotype-Tissue Expression (GTEx) Consortium has published its final series of studies, as part of a final-phase initiative.

14 Sep 2020

Mutant tomato helps to decipher fruiting secrets

Mutant tomato helps to decipher fruiting secrets

It may sound like something out of a science fiction B-movie, but with the help of a mutant tomato, researchers from Japan have discovered that the development process of fruit rewires their central metabolism pathway.

11 Sep 2020

New study unravels genetic vulnerability in breast cancer tumors

New study unravels genetic vulnerability in breast cancer tumors

A new study has unraveled a genetic vulnerability that exists in almost 10% of all breast cancer tumors.

11 Sep 2020

Allergic immune responses protect against bacterial infections

Allergic immune responses protect against bacterial infections

Allergy is one of the most common diseases in Europe, it is estimated that more than 150 million Europeans suffer from recurring allergies and by 2025 this could have increased to half of the entire European population.

10 Sep 2020

Combining stem cell therapy with educational intervention can help children with autism

Combining stem cell therapy with educational intervention can help children with autism

Results of a clinical trial released today in STEM CELLS Translational Medicine indicate that a combination of stem cell therapy and educational intervention can significantly help children with autism spectrum disorder (ASD).

10 Sep 2020

CRISPR in a Box: New educational gene editing tool kit

CRISPR in a Box: New educational gene editing tool kit

Introducing CRISPR in a Box™ - it's not a new crunchy cereal or the latest snack - it's an educational tool kit consisting of state-of-the-science gene editing technology that could be coming to a school near you.

10 Sep 2020

Researchers review the role of macrophage activation syndrome in COVID-19

Researchers review the role of macrophage activation syndrome in COVID-19

A major percentage of COVID-19 cases have become so severe that hospital admissions have become mandatory for both monitoring and treatment.

10 Sep 2020

Novel tool helps select the best gene-editing option

Novel tool helps select the best gene-editing option

Scientists have improved one of the biggest scientific advancement of the past decade.

10 Sep 2020

Researchers reconstruct the birth of a male sex chromosome in Atlantic herring

Researchers reconstruct the birth of a male sex chromosome in Atlantic herring

The evolution of sex chromosomes is of crucial importance in biology as it stabilises the mechanism underlying sex determination and usually results in an equal sex ratio.

10 Sep 2020

An efficient therapeutic strategy against KRAS mutant lung tumors in mice

An efficient therapeutic strategy against KRAS mutant lung tumors in mice

The KRAS oncogene is involved in at least one fifth of all human cancers: KRAS mutations are directly responsible for 32% of lung tumors and 96% of pancreatic tumors.

10 Sep 2020

In-depth study of kidney tumors reveals novel markers of response to immunotherapy

In-depth study of kidney tumors reveals novel markers of response to immunotherapy

Treatments for kidney cancer have improved considerably over the past few decades. In 1988, when Memorial Sloan Kettering oncologist Robert Motzer started researching the disease, the average survival was less than one year.

9 Sep 2020

Researchers uncover tissue reparative role for a rare immune cell in the gut

Researchers uncover tissue reparative role for a rare immune cell in the gut

Scientists from King's College London have discovered an unexpected tissue reparative role for a rare immune cell type in the gut that could tip toward fibrosis or cancer if dysregulated.

9 Sep 2020

New study can help reduce the failure rate of drug development for various diseases

New study can help reduce the failure rate of drug development for various diseases

A novel genetic analysis of blood protein concentrations has shown how genetic information can be applied to support the prioritization of drug targets.

9 Sep 2020

New gene test predicts risk of drug-induced liver injury

New gene test predicts risk of drug-induced liver injury

Researchers who were exploring ways to establish the feasibility of batches of small liver organoids have now identified a new testing approach.

9 Sep 2020

Researchers establish new consortium to study the effect of mutations on the blood characteristics

Researchers establish new consortium to study the effect of mutations on the blood characteristics

A team of researchers has established an international consortium to analyze the blood of scores of people across the globe.

7 Sep 2020

Zika virus infection during pregnancy can cause severe abnormalities in the fetus

Zika virus infection during pregnancy can cause severe abnormalities in the fetus

Zika virus infection during pregnancy can cause severe abnormalities in the fetus, including malformations such as microcephaly. In a small proportion of cases, the disease may lead to miscarriage and perinatal death.

4 Sep 2020

Researchers create an algorithm that predicts allosteric sites in proteins

Researchers create an algorithm that predicts allosteric sites in proteins

A new technology that uses a protein's structure to predict the inner wiring that controls the protein's function and dynamics is now available for scientists to utilize.

4 Sep 2020

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