Genetic News and Research

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Advanced cryo-EM reveals stunning details of viral RNA replication complex structure

For the first time, scientists at the Morgridge Institute for Research have generated near atomic resolution images of a major viral protein complex responsible for replicating the RNA genome of a member of the positive-strand RNA viruses, the large class of viruses that includes coronaviruses and many other pathogens.

21 Jul 2020

Researchers estimate the cost-effectiveness and health impact of BRCA testing

Screening entire populations for breast and ovarian cancer gene mutations could prevent millions more breast and ovarian cancer cases across the world compared to current clinical practice, according to an international study led by Queen Mary University of London.

20 Jul 2020

Type 1 interferon deficiency in the blood could be a hallmark of severe COVID-19

Approximately 5% of people with Covid-19 progress to a severe or critical form, including the development of severe pneumonia that progresses to acute respiratory distress syndrome.

20 Jul 2020

Yale researchers uncover mechanism driving Wolfram Syndrome

Yale pharmacology professor Barbara Ehrlich and her team have uncovered a mechanism driving a rare, lethal disease called Wolfram Syndrome and also a potential treatment.

20 Jul 2020

Researchers construct “DNA droplets” that exhibit dynamic functions

DNA is considered the storage unit of all genetic data in living organisms.

20 Jul 2020

Study shows how proteins prevent DNA replication errors

Two rereading proteins on the DNA assembly line collectively work as an emergency stop button to inhibit replication errors.

20 Jul 2020

Genetic sequencing can reveal evolutionary differences in reef-building corals

Globally, the rising water temperatures caused by pollution and global warming have impacted the coral reefs that are dwindling at an alarming speed.

20 Jul 2020

Study: High levels of iron in the blood can prevent age-related damage

Genes linked to ageing that could help explain why some people age at different rates to others has been identified by scientists.

17 Jul 2020

Hypercompact CRISPR enzyme from bacteriophages expands genome editing toolbox

A recently discovered hypercompact CRISPR enzyme found only in huge bacteriophages, and known as CRISPR-CasΦ, is functional, a new study by Patrick Pausch, Jennifer Doudna and colleagues reports, and it provides a powerful new tool in the CRISPR genome editing toolbox, including because it can target a wider range of genetic sequences compared to Cas9 and Cas12

17 Jul 2020

Study shows how cells respond to nutrient deprivation

The idea of the cell as a city is a common introduction to biology, conjuring depictions of the cell's organelles as power plants, factories, roads, libraries, warehouses and more.

From Harvard Medical School 17 Jul 2020

Researchers use high-quality coral genome to forecast potential bleaching events

In a new approach to conservation genetics, researchers used a high-quality genome of the coral Acropora millepora, along with environmental data, to study this coral's variable responses to climate change, a trait of key conservation importance.

17 Jul 2020

Study focuses on how relationship between plants and microbes responds to drought conditions

Just below ground, an ancient and poorly understood relationship plays out between plants and microbes that infuse the soil.

17 Jul 2020

Study unravels the mysteries of variation in microbiome composition

Oregon State University researchers have made a key advance in understanding how timing impacts the way microorganisms colonize plants, a step that could provide farmers an important tool to boost agricultural production.

17 Jul 2020

Rare inherited mutation in TP53 gene predisposes to a wide range of cancers

Rare inherited mutations in the body's master regulator of the DNA repair system – the TP53 gene – can leave people at a higher risk of developing multiple types of cancer over the course of their lives.

17 Jul 2020

New technique increases the precision of gene editing

A group of biomolecular engineers from Rice University has now identified a C-worthy method that significantly improves the precision of gene editing.

17 Jul 2020

Researchers identify key enzyme that drives the production of ribosomes

Scientists have demonstrated that an enzyme fuels the production of ribosomes—the molecular machines that synthesize all cellular proteins.

From University of Toronto 17 Jul 2020

Credit-card sized tool provides better understanding on breast cancer metastasis

A group of researchers from the University of Toronto have developed a credit-card sized tool for growing cancer cells outside the human body, which they believe will enhance their understanding of breast cancer metastasis.

From University of Toronto 16 Jul 2020

Study shows genetic factors may influence the susceptibility to COVID-19

A new Cleveland Clinic study has identified genetic factors that may influence susceptibility to COVID-19. Published today in BMC Medicine, the study findings could guide personalized treatment for COVID-19.

16 Jul 2020

Unfamiliar social interactions can produce negative emotions in people with autism

Some individuals love meeting new people, while others abhor the idea. For individuals with conditions such as autism, unfamiliar social interactions can produce negative emotions such as fear and anxiety.

15 Jul 2020

Changes in glioblastoma cells influence the effect of different drugs, shows study

Therapies for treating glioblastoma brain cancer can be delivered with greater precision and existing drugs can be used in new ways.

15 Jul 2020

Genetic News and Research

Advanced cryo-EM reveals stunning details of viral RNA replication complex structure

Researchers estimate the cost-effectiveness and health impact of BRCA testing

Type 1 interferon deficiency in the blood could be a hallmark of severe COVID-19

Yale researchers uncover mechanism driving Wolfram Syndrome

Researchers construct “DNA droplets” that exhibit dynamic functions

Study shows how proteins prevent DNA replication errors

Genetic sequencing can reveal evolutionary differences in reef-building corals

Study: High levels of iron in the blood can prevent age-related damage

Hypercompact CRISPR enzyme from bacteriophages expands genome editing toolbox

Study shows how cells respond to nutrient deprivation

Researchers use high-quality coral genome to forecast potential bleaching events

Study focuses on how relationship between plants and microbes responds to drought conditions

Study unravels the mysteries of variation in microbiome composition

Rare inherited mutation in TP53 gene predisposes to a wide range of cancers

New technique increases the precision of gene editing

Researchers identify key enzyme that drives the production of ribosomes

Credit-card sized tool provides better understanding on breast cancer metastasis

Study shows genetic factors may influence the susceptibility to COVID-19

Unfamiliar social interactions can produce negative emotions in people with autism

Changes in glioblastoma cells influence the effect of different drugs, shows study

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