Oligonucleotides News and Research

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Oligonucleotides are short sequences of nucleotides (RNA or DNA), typically with twenty or fewer bases. Automated synthesizers allow the synthesis of oligonucleotides up to 160 to 200 bases.

Study identifies new therapy to treat cystic fibrosis

The process of making proteins from genes is similar to that of a factory, where employees must follow a set of instructions that are both effective and precise.

31 Jan 2022

Aptamers for Targeting SARS-CoV-2 Proteins

AMSBIO has further expanded its product range to help in the fight against COVID-19 with the introduction of a new range of aptamers targeting SARS-CoV-2 proteins to aid development of new kits and assays.

From AMS Biotechnology 15 Sep 2021

Researchers uncover cellular mechanisms by which the silencing therapies act in cells

Gene silencing therapies are used to interfere with, or "silence", the expression of genes that are associated with disorders. Now, a team at TMDU has uncovered some of the cellular mechanisms by which the silencing therapies act in cells.

7 Jul 2021

An efficient automated method for production of synthetic DNA

Chemically synthesized short DNA sequences are extremely important ingredients with countless uses in research laboratories, hospitals, and in industry, like in the method for identifying COVID-19.

13 May 2021

New highly sensitive RNA detection method advances in situ transcriptomics

Human cells typically transcribe half of their roughly 20,000 genes into RNA molecules at any given time. Just like with proteins, the function of those RNA species not only relies on their abundance but also their precise localization within the 3D space of each cell.

18 Mar 2021

Researchers demonstrate strategy to control chemical reactions using antibodies

Antibodies are remarkable biomarkers: they are the cues that provide us with indications about many diseases and how our immune system counter them. Now a group of scientists from the University of Rome, Tor Vergata (Italy) has found a way to repurpose them so that they can trigger a specific chemical reaction.

8 Dec 2020

Research projects receive BTCA awards to develop new drugs

Five research projects with exceptional promise to deliver new life-changing and health-altering therapies have received the inaugural Blavatnik Therapeutics Challenge Awards (BTCA) at Harvard Medical School.

From Harvard Medical School 30 Oct 2020

Bioengineers detect the presence of maxRNA on the surface of human cells

Bioengineers have demonstrated that RNA produced by the human genome is found on the surface of human cells.

11 Sep 2020

RNA-based therapeutic approach could be used to cure hereditary diseases

Short RNA molecules can be used as medication. Their effectiveness is based on the genetic information they carry: therapeutic RNA can bind to the body's own RNA and thus influence how it functions.

19 Aug 2020

Study shows efficacy of L-Grb2 in preclinical models of ovarian and uterine cancer

The cover for issue 29 of Oncotarget features Figure 5, "In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model," by Lara, et al. which reported that adaptor proteins such as growth factor receptor-bound protein-2 play important roles in cancer cell signaling.

23 Jul 2020