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Study develops a highly efficient expression system for high protease yield

Proteases, one of the most inventive products, are utilized to enhance the efficacy of feed additives.

28 Sep 2021

Researchers suggest new strategies for finding drugs that neutralize key enzymes

Scientists from the UK's University of Bath explore racemases - an important type of enzyme that is linked to certain cancers and other life-threatening diseases while also being critical to cell function - in a paper published in the prestigious journal Chemical Society Reviews. The scientists also propose new strategies for finding drugs that neutralize these enzymes.

From University of Bath 26 May 2021

New drug-like compound designed to stop malaria in its tracks

Researchers at the Francis Crick Institute and the Latvian Institute of Organic Synthesis have designed a drug-like compound which effectively blocks a critical step in the malaria parasite life cycle and are working to develop this compound into a potential first of its kind malaria treatment.

13 May 2021

Study reveals mechanism by which ibuprofen prevents RAC1B alternative splicing in colorectal cells

Oncotarget published "Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells" which reported that although the molecular mechanism behind the antitumor properties of NSAIDs has been largely attributed to inhibition of cyclooxygenases , several studies have shown that the chemopreventive properties of ibuprofen also involve multiple COX-independent effects.

23 Mar 2021

Genetic flaw shows promise for treating eye disease

A genetic flaw may hold the key to delay or prevent the onset of a serious eye disorder that can result in blindness and vision loss.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 17 Mar 2021

Researchers define cancer invasion machinery orchestrated by cancer gene

Researchers at the University of Helsinki have defined a cancer invasion machinery, which is orchestrated by a frequently mutated cancer gene called Ras. When signaling from Ras protein becomes abnormally high, like it does in many cancers, this switches on the cellular machinery that helps the cancer cells to depart from the tissue from which the cells have developed.

20 Jan 2021

New version of phototoxic protein helps control intracellular processes

Researchers have designed an improved version of a genetically encoded phototoxic synthesizer that helps regulate intracellular processes through light.

18 Dec 2020

Study sheds new light on a genetic developmental disorder

The rare hereditary developmental disorder, called Meier-Gorlin syndrome, or MGS for short, causes dwarfism, missing patella, a small brain, small ears, and other skeletal abnormalities. This condition leads to stillbirths and miscarriages in severe cases.

15 Dec 2020

Mature SARS-CoV-2 particle development by host-protein interactions

The proteins of SARS-CoV-2 play a key role in self-arrangement and particle formation, and current work suggests that an assembly is formed in the lipid bilayer of the endoplasmic reticulum.

3 Nov 2020

Pancreatic cancer cells avert starvation by signaling to nerves, shows study

Pancreatic cancer cells avert starvation by signaling to nerves, which grow into dense tumors and secrete nutrients. This is the finding of a study with experiments in cancer cells, mice, and human tissue samples published online on November 2 in Cell.

3 Nov 2020

Researchers unravel the molecular basis underlying colorectal cancer

A team of scientists has unraveled the molecular mechanism behind one of the causes of colorectal cancer, and a treatment target.

15 Sep 2020

Researchers identify metabolically responsive “switch” that reduces tumor growth

According to a study the enzyme called serine palmitoyl-transferase can be utilized as a metabolically responsive “switch” that reduces the growth of tumor.

13 Aug 2020

Test pinpoints which people with gonorrhea can be treated with ciprofloxacin

A test designed by UCLA researchers can pinpoint which people with gonorrhea will respond successfully to the inexpensive oral antibiotic ciprofloxacin, which had previously been sidelined over concerns the bacterium that causes the infection was becoming resistant to it.

10 Aug 2020