Oncology News and Research

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Oncology, meaning bulk, mass, or tumor, and the suffix ''-logy'', meaning "study of") is a branch of medicine that deals with tumors (cancer). A medical professional who practices oncology is an ''oncologist''.

Advanced cryo-EM reveals stunning details of viral RNA replication complex structure

For the first time, scientists at the Morgridge Institute for Research have generated near atomic resolution images of a major viral protein complex responsible for replicating the RNA genome of a member of the positive-strand RNA viruses, the large class of viruses that includes coronaviruses and many other pathogens.

21 Jul 2020

Rare inherited mutation in TP53 gene predisposes to a wide range of cancers

Rare inherited mutations in the body's master regulator of the DNA repair system – the TP53 gene – can leave people at a higher risk of developing multiple types of cancer over the course of their lives.

17 Jul 2020

New, promising CAR T cell therapy results in exceptional patient recovery

In a clinical trial evaluating a novel immunotherapy option for cancer treatment, a child with rhabdomyosarcoma, a form of muscle cancer, that had spread to the bone marrow, showed no detectable cancer following treatment with chimeric antigen receptor (CAR) T cells that were engineered to target the HER2 protein on the surface of cancerthe cells.

16 Jul 2020

Imaging mass spectrometry identifies tumor markers for head and neck squamous cell carcinoma

Volume 11, Issue 28 of Oncotarget features "Lipid and protein tumor markers for head and neck squamous cell carcinoma identified by imaging mass spectrometry" by Schmidt et. al. which reported that the authors used MALDI imaging mass spectrometry and immunohistochemistry to seek tumor-specific expression of proteins and lipids in HNSCC samples.

15 Jul 2020

Golgi membrane protein drives growth and invasion of breast cancer

The cover for issue 28 of Oncotarget features Figure 5, "TMEM165 expression levels alters N-linked glycosylation," by Murali, et al., and reported that the TMEM165 protein was not detected in non-malignant matched breast tissues and was detected in invasive ductal breast carcinoma tissues by mass spectrometry.

15 Jul 2020

Fewer but larger doses of radiotherapy are safe for patients with early breast cancer

A lower total dose of radiotherapy delivered in fewer but larger doses is as safe in the long term as breast cancer radiotherapy courses giving multiple small doses, according to the final results of a 10-year study.

15 Jul 2020

PET radiotracer is safe and effective for imaging malignant brain tumors

A first-in-human study presented at the Society of Nuclear Medicine and Molecular Imaging 2020 Annual Meeting has demonstrated the safety, favorable pharmacokinetic and dosimetry profile of 64Cu-EBRGD, a new, relatively long-lived PET tracer, in patients with glioblastomas.

14 Jul 2020

Nano-radiomics uses imaging data to assess changes in the tumor microenvironment

Research has shown that the tumor microenvironment (TME) can help cancers grow and evade the immune response.The TME has even been shown to inhibit cellular immunotherapy, a novel form of treatment in which the cells of a patient's immune system are re-engineered in the lab to attack cancer cells.

14 Jul 2020

NCCN Distress Thermometer translated into 46 languages for global accessibility

The National Comprehensive Cancer Network--an alliance of leading cancer centers in the United States--today announced the NCCN Distress Thermometer has been translated into 46 languages.

14 Jul 2020

Total-body dynamic PET scans can produce high-quality images of metastatic cancer

Results from the first study using uEXPLORER to conduct total-body dynamic positron emission tomography (PET) scans in cancer patients show that it can be used to generate high-quality images of metastatic cancer.

14 Jul 2020

Study confirms the efficacy of PSMA PET/CT in detection and management of recurrent prostate cancer

New research confirms the high impact of PSMA PET/CT in the detection and management of recurrent disease in prostate cancer patients.

14 Jul 2020

Genomics study in Black Americans could lead to precision prostate cancer therapies

Black men in the United States are known to suffer disproportionately from prostate cancer, but few studies have investigated whether genetic differences in prostate tumors could have anything to do with these health disparities.

13 Jul 2020

New start-up to exploit novel drug-transporting technology

Researchers from IRB Barcelona, the University of Barcelona (UB) and the Sant Joan de Déu Research Institute - Hospital Sant Joan de Déu (SJD) have set up Gate2Brain, a company based on a novel technology developed at IRB Barcelona to transport drugs into the brain.

10 Jul 2020

Preventing immune cell reprogramming could be a new way to stop breast cancer metastasis

Natural killer cells, a type of immune cell, are known to limit metastasis by inducing the death of cancer cells. But metastases still form in patients, so there must be ways for cancer cells to escape.

10 Jul 2020

DNA repair tool is tailored to deal with specific type of complex break, study shows

Our cells are constantly dividing, and as they do, the DNA molecule - our genetic code - sometimes gets broken. DNA has twin strands, and a break in both is considered especially dangerous.

7 Jul 2020

Genome sequencing reveals signposts in DNA for cancer, disease risk

By sequencing entire genomes for DNA modifications, and analyzing both cancer tissues and healthy ones, Hackensack Meridian Health researchers and doctors have found what could be a key to risks for cancer and other diseases: specific locations in the DNA where those expression changes (methylation) are imbalanced, according to a new publication.

30 Jun 2020

Oncology News and Research

Advanced cryo-EM reveals stunning details of viral RNA replication complex structure

Rare inherited mutation in TP53 gene predisposes to a wide range of cancers

New, promising CAR T cell therapy results in exceptional patient recovery

Imaging mass spectrometry identifies tumor markers for head and neck squamous cell carcinoma

Golgi membrane protein drives growth and invasion of breast cancer

Fewer but larger doses of radiotherapy are safe for patients with early breast cancer

PET radiotracer is safe and effective for imaging malignant brain tumors

Nano-radiomics uses imaging data to assess changes in the tumor microenvironment

NCCN Distress Thermometer translated into 46 languages for global accessibility

Total-body dynamic PET scans can produce high-quality images of metastatic cancer

Study confirms the efficacy of PSMA PET/CT in detection and management of recurrent prostate cancer

Genomics study in Black Americans could lead to precision prostate cancer therapies

New start-up to exploit novel drug-transporting technology

Preventing immune cell reprogramming could be a new way to stop breast cancer metastasis

DNA repair tool is tailored to deal with specific type of complex break, study shows

Genome sequencing reveals signposts in DNA for cancer, disease risk

Researchers identify genetic variants that predispose to cancer

Scientists study how cancer cells in the liver react to magnetic nanoparticles

Study identifies complex functional, physical interactions between p53 gene and the INSR pathway

Blocking A 'Jamming Signal' Can Unleash Immune System To Fight Tumors

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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