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New model can help identify potential drug targets for ulcerative colitis

Scientists from the Lerner Research Institute at Cleveland Clinic have designed an innovative, patient-derived model of ulcerative colitis that will help scale up studies into new therapies for chronic inflammatory bowel disease.

12 Jan 2021

Regulatory T cells found to promote inflammation in periodontal disease

Researchers still do not know much about diseases like periodontitis, rheumatoid arthritis, and osteoporosis, which are characterized by bone loss.

12 Jan 2021

Augmented response of immune system explains COVID-19 severity in patients with hypertension

COVID-19 patients who also suffer from high blood pressure are more likely to fall severely ill with the disease, which also leaves them at greater risk of death.

12 Jan 2021

Pillar-like molecules could be used as biosensors to detect metabolites

Metabolites are essentially organic molecules that are formed or participate during the biochemical reactions that continuously occur in an organism.

12 Jan 2021

Study reveals richness of space-time gene expression dynamics of the liver

Nothing in biology is static. Biological processes fluctuate over time, and if we are to put together an accurate picture of cells, tissues, organs etc., we have to take into account their temporal patterns. In fact, this effort has given rise to an entire field of study known as "chronobiology".

12 Jan 2021

Automated electron microscopy helps visualize neural function and behavior

Researchers are still clueless about how the neural networks are linked together to make functional circuits.

From Harvard Medical School 12 Jan 2021

Researchers reveal surprising propulsion system used by stem cells

Researchers have discovered the surprising propulsion system that enables these regenerative cells to migrate through surrounding tissue to repair the damage.

12 Jan 2021

New discovery helps explain how COVID-19 suppresses the body’s immune response

Seeking to understand why COVID-19 is able to suppress the body's immune response, new research from the USC Leonard Davis School of Gerontology suggests that mitochondria are one of the first lines of defense against COVID-19 and identifies key differences in how SARS-CoV-2, the virus that causes COVID-19, interacts with mitochondrial genes when compared to other viruses.

12 Jan 2021

Researchers show how the genetic material travels from cell to cell

The genetic material of plants, animals, and humans is well protected in the nucleus of each cell and stores all the information that forms an organism. For example, information about the size or color of flowers, hair or fur is predefined here.

12 Jan 2021

Study unravels the mystery of infectious virion formation

Researchers have for the first time identified the way viruses like the poliovirus and the common cold virus 'package up' their genetic code, allowing them to infect cells.

11 Jan 2021

Researchers discover new way to control natural killer cells in immune system

UC San Francisco scientists have discovered a new way to control the immune system's "natural killer" (NK) cells, a finding with implications for novel cell therapies and tissue implants that can evade immune rejection.

11 Jan 2021

Proteogenomic study may lead to more effective treatments for head and neck squamous cell carcinoma

Proteogenomic studies may provide a better understanding of how to match cancer patients with an effective treatment for their specific cancer.

8 Jan 2021

Scientists use stem cells to reverse memory and learning deficits in mice with craniosynostosis

In an effort to regenerate portions of the skull, researchers have successfully used stem cells, corrected the shape of the skull, and thus reversed learning and memory deficits in young mice afflicted with craniosynostosis.

8 Jan 2021

New class of protein materials can influence cell signaling

A new study has revealed that a novel class of protein material that communicates with living cells without being absorbed by them can affect cell signaling. The protein material does this by attaching and sequestering cell surface receptors.

7 Jan 2021

Study explores why Shiga toxin-producing E. coli infections are so dangerous

E. coli food poisoning is one of the worst food poisonings, causing bloody diarrhea and kidney damage. But all the carnage might be just an unintended side effect, researchers from UConn Health report in the 27 November issue of Science Immunology. Their findings might lead to more effective treatments for this potentially deadly disease.

7 Jan 2021

Researchers create molecular ON-OFF switches to regulate CAR T cell activity

CAR T cells are a breakthrough class of effective but often toxic cancer therapies. To prevent overactivation, switchable CAR T cells were engineered that can be turned on and off with an approved, widely used cancer drug.

7 Jan 2021

Study addresses mystery of how chromosomes are inherited during cell division

Starting as a single cell, organisms undergo millions of generations of divisions to ultimately generate the bones, heart, brain and other components that make up a living being. The mainspring within this intricate process is the transfer of DNA through each subsequent cell split within discrete packets called chromosomes.

7 Jan 2021

DNA-editing technique used to extend lifespan of mice with progeria

Researchers have successfully used a DNA-editing technique to extend the lifespan of mice with the genetic variation associated with progeria, a rare genetic disease that causes extreme premature aging in children and can significantly shorten their life expectancy.

From National Human Genome Research Institute (NHGRI) 7 Jan 2021

Microbe found in the colon may promote breast cancers

A microbe found in the colon and commonly associated with the development of colitis and colon cancer also may play a role in the development of some breast cancers, according to new research from investigators with the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

7 Jan 2021