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Liver Cancers With Key Epigenetic Alteration Tend to Have a Poor Clinical Prognosis

Researchers at the Josep Carreras Leukaemia Research Institute, led by Dr. Manel Esteller, have discovered a key epigenetic alteration that anticipates the clinical course of liver cancer.

17 May 2023

Long-Ignored Antibiotic may Provide Much-Needed Protection Against Multi-Drug Resistant Bacteria

An old antibiotic may provide much-needed protection against multi-drug resistant bacterial infections, according to a new study publishing May 16th in the open access journal PLOS Biology by James Kirby of Harvard Medical School, US, and colleagues.

17 May 2023

Study Finds Methylated CD Derivatives as Effective Stabilizers for Supersaturated Drugs

In the medicine market, most newly introduced drugs and drug candidates show poor water solubility, which prevents their absorption in the body. This, in turn, limits their therapeutic efficiency.

16 May 2023

Brain-Wide Mapping Reveals How Serotonin Affects Animal Behavior

Because serotonin is one of the primary chemicals the brain uses to influence mood and behavior, it is also the most common target of psychiatric drugs.

16 May 2023

Study Finds Place of Transcription Start Often Determines the Place of Transcription End

Each gene in the human DNA has a start and an endpoint. It is critical to correctly define the gene's extremities to make functional proteins. Much study has been conducted to identify what determines when, where, and at which place on the DNA a gene “starts.”

16 May 2023

Researchers Develop a System to Deliver Antioxidants to the Mitochondria

A new drug delivery system delivers an antioxidant directly to mitochondria in the liver, mitigating the effects of oxidative stress.

11 May 2023

Using Mass-Spectrometry-Based Cancer Proteomics Datasets to Discover Potential Therapeutic Targets

A new research perspective was published in Oncotarget's Volume 14 on May 4, 2023, entitled, "Using cancer proteomics data to identify gene candidates for therapeutic targeting."

11 May 2023

Scientists Engineer the First CRISPR-Based Drug Candidate to Directly Target E. Coli

Many people have experienced infections from E. coli, which are primarily seen as inconvenient and unpleasant.

10 May 2023

Novel Technique Enables In Vivo Cross‐linking for Protein Complex Analysis

As the executor of life activities, proteins exert their specific biological functions through interactions such as forming protein complexes.

10 May 2023

Breakthrough "Gene Silencing" Technology Could Revolutionize the Development of DNAzymes

Researchers from the University of California, Irvine have developed a DNA enzyme – or DNAzyme – that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact.

9 May 2023

Discovering Novel Senolytic Compounds with the Power of Artificial Intelligence

A new publication in the May issue of Nature Aging by researchers from Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, demonstrates the power of artificial intelligence (AI) to discover novel senolytic compounds, a class of small molecules under intense study for their ability to suppress age-related processes such as fibrosis, inflammation and cancer.

8 May 2023

Analyzing the Complex Sequence of Events Involved in Beta-Arrestin Interactions

Proteins that work like air traffic controllers, controlling the flow of signals in and out of human cells, have been examined in unparalleled detail for the first time using modern microscope techniques.

5 May 2023

Study Reveals an Immunological Strategy to Overcome Microbiome-Related Immunotherapy Resistance

Cancer immunotherapy has transformed the treatment of many types of cancer. Yet, for reasons that remain poorly understood, not all patients get the same benefit from these powerful therapies.

4 May 2023

Research Sheds Light on How Nature has Optimized Photosynthesis

Photosynthesis plays a crucial role in shaping and sustaining life on Earth, yet many aspects of the process remain a mystery.

4 May 2023

Inhibiting a Tiny RNA Could Help Improve Immune, Bone, and Muscle Health With Age

Inhibiting a tiny RNA whose levels significantly increase with age, along with problems like weaker bones and sagging muscles, may be a way to keep our bodies more youthful and healthy, scientists say.

3 May 2023

Reducing Intracellular Ice Formation in Advanced Cell Models

Researchers at the University of Warwick have discovered a way for storing advanced cell models.

From The University of Warwick 3 May 2023

Understanding the Process of Gene Regulation Using Cryogenic Electron Microscopy

LMU researchers show detailed displacement process of TBP transcription factor from DNA by Mot1 enzyme.

2 May 2023

The Pivotal Role of Combinatorial CRISPR Gene Editing in the Elimination of HIV-1 Infection

Recent research from Temple University’s Lewis Katz School of Medicine and the University of Nebraska Medical Center demonstrates that gene-editing therapy aimed at two targets - HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that aids the virus getting into cells—can effectively eliminate HIV infection.

2 May 2023

Mirror-Image Versions of a Small Molecule Pave New Way for Cancer Drug Discovery

Scripps Research scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs.

28 Apr 2023

High-Throughput Assay to Analyze the Effects of CAR-T Cells Using Image Cytometry

The April 2023 issue of SLAS Discovery contains six full-length articles and one mini-review covering high-throughput screening (HTS) for protease-inhibiting drugs, high-content phenotypic screening and other life sciences research.

28 Apr 2023

Molecule News and Research

Liver Cancers With Key Epigenetic Alteration Tend to Have a Poor Clinical Prognosis

Long-Ignored Antibiotic may Provide Much-Needed Protection Against Multi-Drug Resistant Bacteria

Study Finds Methylated CD Derivatives as Effective Stabilizers for Supersaturated Drugs

Brain-Wide Mapping Reveals How Serotonin Affects Animal Behavior

Study Finds Place of Transcription Start Often Determines the Place of Transcription End

Researchers Develop a System to Deliver Antioxidants to the Mitochondria

Using Mass-Spectrometry-Based Cancer Proteomics Datasets to Discover Potential Therapeutic Targets

Scientists Engineer the First CRISPR-Based Drug Candidate to Directly Target E. Coli

Novel Technique Enables In Vivo Cross‐linking for Protein Complex Analysis

Breakthrough "Gene Silencing" Technology Could Revolutionize the Development of DNAzymes

Discovering Novel Senolytic Compounds with the Power of Artificial Intelligence

Analyzing the Complex Sequence of Events Involved in Beta-Arrestin Interactions

Study Reveals an Immunological Strategy to Overcome Microbiome-Related Immunotherapy Resistance

Research Sheds Light on How Nature has Optimized Photosynthesis

Inhibiting a Tiny RNA Could Help Improve Immune, Bone, and Muscle Health With Age

Reducing Intracellular Ice Formation in Advanced Cell Models

Understanding the Process of Gene Regulation Using Cryogenic Electron Microscopy

The Pivotal Role of Combinatorial CRISPR Gene Editing in the Elimination of HIV-1 Infection

Mirror-Image Versions of a Small Molecule Pave New Way for Cancer Drug Discovery

High-Throughput Assay to Analyze the Effects of CAR-T Cells Using Image Cytometry

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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