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New genetic engineering strategy largely reduces tau protein levels in Alzheimer’s animal model

A genetic engineering approach has helped scientists to drastically decrease the levels of tau protein.

22 Mar 2021

New highly sensitive RNA detection method advances in situ transcriptomics

Human cells typically transcribe half of their roughly 20,000 genes into RNA molecules at any given time. Just like with proteins, the function of those RNA species not only relies on their abundance but also their precise localization within the 3D space of each cell.

18 Mar 2021

High-resolution map of yeast genome can shed light on development responses in higher organisms

A new study explains an effort to create the most detailed and high-resolution map of gene regulation and chromosome architecture in yeast organisms.

15 Mar 2021

ADAR1 protein offers a potential therapeutic target for cancer

A research team has discovered a new role of ADAR1 and found that the ADAR1p110 isoform controls genome stability at the ends of chromosomes.

15 Mar 2021

Cryogenic electron microscopy helps visualize 3D structure of complex responsible for gene regulation

A research team has looked inside a human cell to visualize a multi-subunit machine that is responsible for controlling the expression of genes.

15 Mar 2021

Study offers fresh insights into infection process during spaceflight

Astronauts face many challenges to their health, due to the exceptional conditions of spaceflight. Among these are a variety of infectious microbes that can attack their suppressed immune systems.

10 Mar 2021

Novel agonistic effect of polyphenol compound could treat amyloidosis, other metabolic disorders

Reportedly, Curcumin has several physiological activities, which include anti-inflammatory, anti-oxidation, anti-amyloid, and anti-cancer properties.

1 Mar 2021

Study reveals mechanism through which plant hormone controls cell division

The mechanism through which cytokinin—a plant hormone—regulates the division of cells has been identified.

26 Feb 2021

Fungal hybridization confers greater adaptive potential in Verticillium longisporum

Several plant pathogens belong to the genus Verticillium and affect many different plant hosts.

24 Feb 2021

Jumping genes are an important force in the creation of new genes during evolution, shows study

In the same way that Lego pieces can be arranged in new ways to build a variety of structures, genetic elements can be mixed and matched to create new genes, according to new research.

23 Feb 2021

Advanced explainable AI to solve regulatory instructions encoded in DNA

Researchers at the Stowers Institute for Medical Research, in collaboration with colleagues at Stanford University and Technical University of Munich have developed advanced explainable artificial intelligence (AI) in a technical tour de force to decipher regulatory instructions encoded in DNA.

19 Feb 2021

Animal model yields important insights into T cell exhaustion

T lymphocytes, or T cells, are an important component of our immune system. They can recognize foreign proteins, so-called antigens, as peptide fragments - for instance, those derived from viruses or cancer cells.

15 Feb 2021

Cell cycle of cancer cells can be disrupted using two commercially available inhibitors

With two commercially available inhibitors, the cell cycle of the cancer cells in the childhood tumor neuroblastoma can be disrupted at a key point causing tumor cell death.

12 Feb 2021

Scientists use new approach to avert drug resistance in glioblastomas

In far too many cases over the years, scientists have discovered promising new cancer treatments, only to report later that the tumor cells found ways to become resistant. These disappointing results have made overcoming drug resistance a major goal in cancer research.

11 Feb 2021

Unusual DNA folding leads to higher mutation rates

DNA sequences that can fold into shapes other than the classic double helix tend to have higher mutation rates than other regions in the human genome.

From Penn State University 10 Feb 2021

New protein quality control system could enhance full-length translation in bacteria

Professor Sang Woo’s research group has designed a synthetic protein quality control system to improve the full-length translation in bacteria.

9 Feb 2021

Scientists determine biological mechanism that may lead to more efficient antibiotics

Hormone-mimicking molecules that trigger the production of antibiotics in soil bacteria could present new opportunities for drugs that are right under our feet.

From The University of Warwick 5 Feb 2021

LEAFY protein licenses cell reprogramming to floral fate

Cells don't express all the genes they contain all the time. The portion of our genome that encodes eye color, for example, doesn't need to be turned on in liver cells. In plants, genes encoding the structure of a flower can be turned off in cells that will form a leaf.

28 Jan 2021

Pioneer transcription factors help turn on key genes that give cells unique properties

Biologists have long wondered how complex organisms contain a variety of dramatically different types of cells with specialized functions, even though all of those cells are genetically identical.

25 Jan 2021

Study shows how nonmalignant cells adapt to harsh tumor microenvironment

Cells need energy to survive and thrive. Generally, if oxygen is available, cells will oxidize glucose to carbon dioxide, which is very efficient, much like burning gasoline in your car. However, even in the presence of adequate oxygen, many malignant cells choose instead to ferment glucose to lactic acid, which is a much less efficient process.

20 Jan 2021

Transcription News and Research

New genetic engineering strategy largely reduces tau protein levels in Alzheimer’s animal model

New highly sensitive RNA detection method advances in situ transcriptomics

High-resolution map of yeast genome can shed light on development responses in higher organisms

ADAR1 protein offers a potential therapeutic target for cancer

Cryogenic electron microscopy helps visualize 3D structure of complex responsible for gene regulation

Study offers fresh insights into infection process during spaceflight

Novel agonistic effect of polyphenol compound could treat amyloidosis, other metabolic disorders

Study reveals mechanism through which plant hormone controls cell division

Fungal hybridization confers greater adaptive potential in Verticillium longisporum

Jumping genes are an important force in the creation of new genes during evolution, shows study

Advanced explainable AI to solve regulatory instructions encoded in DNA

Animal model yields important insights into T cell exhaustion

Cell cycle of cancer cells can be disrupted using two commercially available inhibitors

Scientists use new approach to avert drug resistance in glioblastomas

Unusual DNA folding leads to higher mutation rates

New protein quality control system could enhance full-length translation in bacteria

Scientists determine biological mechanism that may lead to more efficient antibiotics

LEAFY protein licenses cell reprogramming to floral fate

Pioneer transcription factors help turn on key genes that give cells unique properties

Study shows how nonmalignant cells adapt to harsh tumor microenvironment

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