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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Blunted inflammatory response could make obese patients more susceptible to severe COVID-19

Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

21 Mar 2023

DNA drugs help restore the normal processing of protein-encoding RNA

A protein named TDP-43 has been lost from its normal location in the nucleus of the cell in virtually all persons having amyotrophic lateral sclerosis (ALS) and in up to half of all cases of frontotemporal dementia and Alzheimer’s disease (AD).

From UC San Diego 20 Mar 2023

Delaying paralysis in ALS by using designer DNA drug

In virtually all persons with amyotrophic lateral sclerosis (ALS) and in up to half of all cases of Alzheimer's disease (AD) and frontotemporal dementia, a protein called TDP-43 is lost from its normal location in the nucleus of the cell.

20 Mar 2023

Using a programmable control switch to deliver therapeutic RNA molecules to target cells

Using an RNA sensor, MIT engineers have designed a new way to trigger cells to turn on a synthetic gene.

17 Mar 2023

Highly sensitive bioluminescent platform for nucleic acid detection

Despite significant advances, numerous highly sensitive viral disease diagnostic tests even now require complex techniques to prepare a sample or decipher a result, making them inconvenient for point-of-care settings or areas with limited resources.

17 Mar 2023

Highlighting a potential sex‐specific precision immunotherapy strategy

Immunotherapy is an effective form of treatment for various types of cancer. However, its effect on pancreatic cancer is restricted and varies between men and women. Karolinska Institutet scientists have observed a possible explanation for this gender difference.

17 Mar 2023

High correlation between the product of a gene in the majority of cancers

The product of a gene expressed in most cancers, including the most prevalent type of head and neck cancer, has been linked to elevated levels of white blood cells that produce antibodies inside tumors, according to researchers at the University of California San Diego School of Medicine and UC San Diego Moores Cancer Center.

14 Mar 2023

Rice biologists embark on a three-year project to create genetically encoded antibiotics

Synthetic biologists at Rice University are embarking on a three-year project to create "genetically encoded antibiotics," strands of RNA that bacteria will readily copy and share that will selectively kill only disease-causing, pathogenic bacteria.

14 Mar 2023

Significance of astrocyte–neuron interactions in fine-tuning brain function

Humans learn to handle a variety of skilled movements throughout their lives, from driving a car to swinging a tennis racket. Neurons are not the only ones who implement this learning, but a new study from The Picower Institute for Learning and Memory at MIT shows that astrocytes play an important role as well.

From Massachusetts Institute of Technology (MIT) 14 Mar 2023

A reliable way to downregulate gene translation in plants

By carefully constructing upstream open reading frames (uORFs), Caixia Gao’s team at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS) has created a new technique for downregulating gene translation to a predictable and desirable level in plants.

10 Mar 2023

Study identifies previously unknown cell types that drive the onset of osteoarthritis

A Michigan Medicine study has identified a new potential target for treating osteoarthritis – a debilitating joint disease that affects over 31 million Americans and is a leading cause of disability worldwide.

10 Mar 2023

Novel protein complex plays a significant role in RNA protection

Two proteins help in protecting and stabilizing RNA as it travels through the cell carrying muscle-forming code. Studying this RNA-stabilizing complex further may have ramifications for muscle recovery and disease treatment.

10 Mar 2023

Study shows link between a mitochondrial metabolite and activation of inflammatory response

A new study shows for the first time a connection between a mitochondrial metabolite and the activation of an inflammatory response.

9 Mar 2023

Study pinpoints a splicing deregulation that causes therapeutic vulnerability in pediatric AML

Pediatric acute myeloid leukemia or pAML is a childhood blood cancer, one that has proved confounding to clinicians and researchers, with a high relapse rate and relatively few identified genetic mutations (compared to the adult version) that might explain its cause.

8 Mar 2023

Scientists discover mechanism behind how plants can develop long-term immunity to stress

A mechanism behind how plants can develop long-term immunity to stress has been discovered by scientists at the University of Sheffield.

8 Mar 2023

Using data from Sanger sequencing to quantify of genetic variants in bacterial cultures

Genetic variations, such as mutations, recombinations, or transpositions occur naturally in cultured microorganisms and are often considered nonneutral mutations.

7 Mar 2023

Novel way to block the death of nerve cells in MND

Scientists have found a novel way to block the transportation of mutant RNA and subsequent production of toxic repeat proteins which lead to the death of nerve cells in the most common subtypes of motor neurone disease (MND) and frontotemporal dementia (FTD).

2 Mar 2023

RNA News and Research

Blunted inflammatory response could make obese patients more susceptible to severe COVID-19

DNA drugs help restore the normal processing of protein-encoding RNA

Delaying paralysis in ALS by using designer DNA drug

Using a programmable control switch to deliver therapeutic RNA molecules to target cells

Highly sensitive bioluminescent platform for nucleic acid detection

Highlighting a potential sex‐specific precision immunotherapy strategy

High correlation between the product of a gene in the majority of cancers

Rice biologists embark on a three-year project to create genetically encoded antibiotics

Significance of astrocyte–neuron interactions in fine-tuning brain function

A reliable way to downregulate gene translation in plants

Study identifies previously unknown cell types that drive the onset of osteoarthritis

Novel protein complex plays a significant role in RNA protection

Study shows link between a mitochondrial metabolite and activation of inflammatory response

Study pinpoints a splicing deregulation that causes therapeutic vulnerability in pediatric AML

Scientists discover mechanism behind how plants can develop long-term immunity to stress

Using data from Sanger sequencing to quantify of genetic variants in bacterial cultures

Novel way to block the death of nerve cells in MND

Elaborating how amino acids shaped the genetic code of ancient microbes

RNA modification plays a vital role in TDP-43-related neurodegeneration in ALS

Nanosatellite paves the way for developing RNA-based medicines

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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