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Study explores the impact of solute carriers on the activity and potency of cytotoxic drugs

At the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, scientists have investigated how solute carriers (SLCs)—a large class of membrane transport proteins—affect the activity and potency of cytotoxic drugs, for example, those used to treat leukemia and other cancers.

10 Mar 2020

New chromosome-level detectors developed to monitor cellular activity

For researchers investigating the regulatory processes in cells that are vital to all life, an innovative system that amplifies gene expression signals could be a turning point.

10 Mar 2020

In a first, AI discovers antibiotic that kills dangerous bacteria

For the very first time, artificial intelligence (AI) has been used to discover a new type of antibiotic.

From Massachusetts Institute of Technology (MIT) 10 Mar 2020

New discovery reveals earliest known instance of complex form of protein regulation

Researchers have given a new life to the ancient history of two proteins, thus gaining insights into the origin of an age-old molecular partnership.

9 Mar 2020

A new breakthrough could lead to better approaches for preventing breast cancer metastasis

New breakthrough in breast cancer could enable the development of better approaches to prevent the spread of cancer cells to other organs in the body, thereby effectively bringing down mortality in patients suffering from breast cancer.

9 Mar 2020

Researchers successfully crystallize and map novel conformation of LeuT transporter

Researchers at the University of Copenhagen have mapped a novel structure of what is called a “neurotransmitter: sodium symporter.”

9 Mar 2020

Structure of intact IgE revealed by electron microscopy

Scientists at Aarhus University have described the structure of an IgE antibody for the very first time.

9 Mar 2020

New method has revealed how cells communicate

A new light technique has been developed by a team of researchers in the UK that can reveal how cells communicate in disease scenarios.

27 Feb 2020

Nucleosomal DNA Dynamics Mediate Oct4 Pioneer Factor Binding

An international team of researchers has disproved the role of an essential protein, known as Oct4, in regulating gene expression.

22 Feb 2020

WDR74 modulates melanoma tumorigenesis and metastasis through the RPL5–MDM2–p53 pathway

A team of scientists has discovered that the WDR74 protein plays a vital role in metastasis progression in lung cancer and melanoma primary tumors.

22 Feb 2020

New correlative, 3D, super resolution imaging platform reveals unexpected findings in mammalian cells

Researchers have developed a platform for the 3D super-resolution imaging at the nanoscale level that has revealed unexpected findings in mammalian cells.

21 Feb 2020

Deep-learning based tool super-resolves imaging in point scanning systems

Researchers have developed a point scanning approach that increases the spatiotemporal resolution of imaging systems to unprecedented levels.

21 Feb 2020

Distinct loss-of-function variants cause shared clinical features in neuronal development disorders

Researchers have shown that mutations in four distinct genes that lead to Kleefstra syndrome.

20 Feb 2020

New single-cell isolation method could revolutionize live cell imaging

Researchers have proposed a new high-throughput, multigenerational time-lapse imaging platform, capable of single-cell screening.

20 Feb 2020

Intact Protein Mass Spectrometry of Cell Culture Harvest Guides Cell Line Development for Trispecific Antibodies

A team in Massachusetts has established a method of profiling of mispairing in antibody assembly.

18 Feb 2020

Mass Spectrometry‐Based Strategies for Therapeutic Antibodies Extensive Characterization and Optimization

For many years’ antibodies have been used in therapeutic applications to treat a plethora of diseases and ailments.

17 Feb 2020

Applying integrated lipidomics and proteomics in multiple myeloma reveals potential disease pathways

A team of Australian researchers has confirmed the feasibility and potential of applying integrated lipidomics and proteomics to malignant plasma cells from myeloma patients.

13 Feb 2020

Considering evolution of the cancer genome in metastatic disease

Metastasis refers to the spread of cancer cells from primary tumors to distant sites that they then colonize to form a metastatic tumor.

13 Feb 2020

A new study finds a potential immunotherapeutic pan-target on cancer cells

In a genome-wide CRISPR-Cas9 screen published in Nature Immunology in January 2020, a group of researchers described a potential universal target on cancer cells.

12 Feb 2020

Progesterone induces sperm release from oviductal epithelial cells by modifying sperm proteomics

An international team of researchers has uncovered valuable insights on the underlying mechanisms involved in the process of sperm release from the oviduct.

10 Feb 2020

Cell News and Research

Study explores the impact of solute carriers on the activity and potency of cytotoxic drugs

New chromosome-level detectors developed to monitor cellular activity

In a first, AI discovers antibiotic that kills dangerous bacteria

New discovery reveals earliest known instance of complex form of protein regulation

A new breakthrough could lead to better approaches for preventing breast cancer metastasis

Researchers successfully crystallize and map novel conformation of LeuT transporter

Structure of intact IgE revealed by electron microscopy

New method has revealed how cells communicate

Nucleosomal DNA Dynamics Mediate Oct4 Pioneer Factor Binding

WDR74 modulates melanoma tumorigenesis and metastasis through the RPL5–MDM2–p53 pathway

New correlative, 3D, super resolution imaging platform reveals unexpected findings in mammalian cells

Deep-learning based tool super-resolves imaging in point scanning systems

Distinct loss-of-function variants cause shared clinical features in neuronal development disorders

New single-cell isolation method could revolutionize live cell imaging

Intact Protein Mass Spectrometry of Cell Culture Harvest Guides Cell Line Development for Trispecific Antibodies

Mass Spectrometry‐Based Strategies for Therapeutic Antibodies Extensive Characterization and Optimization

Applying integrated lipidomics and proteomics in multiple myeloma reveals potential disease pathways

Considering evolution of the cancer genome in metastatic disease

A new study finds a potential immunotherapeutic pan-target on cancer cells

Progesterone induces sperm release from oviductal epithelial cells by modifying sperm proteomics

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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