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The Role of DNA Repair Pathways in Antibody Somatic Hypermutation

In a recent online publication in SCIENCE CHINA Life Sciences, researchers from the laboratory of Leng-Siew Yeap at the Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine published a review article entitled "Molecular Mechanisms of DNA Lesion and Repair During Antibody Somatic Hypermutation". This review comprehensively summarizes the mechanisms involved in the generation of antigen-specific diversified antibodies, with a particular focus on the mechanisms that generate high-frequency point mutations and low-frequency deletions and insertions (indels) in antibody genes.

22 Aug 2024

Ancient Viral Remnants Serve as Accurate Aging Clock

DNA markers linked to retroelements - remaining pieces of ancient viral genetic material - in human genes have been found by researchers at Weill Cornell Medicine and the epigenetics startup TruDiagnostic.

20 Aug 2024

Novel Drug Targets in Gardnerella Vaginalis: A Bioinformatics Approach to Combat Bacterial Vaginosis

A computational approach to identify proteins in G. vaginalis that could be potential drug targets.

20 Aug 2024

Advancing Cardiovascular Drug Discovery: Translational Framework Leverages Genetic and Proteomic Insights

A validated framework to translate these recent advances in genoproteomics into clinical applications in cardiovascular drug development.

19 Aug 2024

Light-Activated Macrophages Show Increased Appetite for Cancer Cells

The body has a veritable army constantly on guard to keep us safe from microscopic threats from infections to cancer.

13 Aug 2024

From CRISPR-Cas to Fanzor system: New frontiers in gene editing

The features of various CRISPR-Cas systems, including CRISPR-associated transposons (CASTs) and the eukaryotic equivalent of CRISPR-Cas systems, Fanzor systems.

9 Aug 2024

Breakthrough Compound ZTA-261 Shows Promise for Safer Lipid Disorder Treatment

Scientists at Nagoya University in Japan have made a significant breakthrough in treating lipid disorders.

8 Aug 2024

Cyclo(L-Pro-L-Tyr): A Promising Tyrosinase Inhibitor Derived from Skin Bacteria

Melanin protects the skin-;the body's largest organ and a vital component of the immune system-;from the damaging effects of ultraviolet (UV) radiation.

6 Aug 2024

Geographic Origin Plays Key Role in Tuberculosis Infection, Harvard Study Finds

For some forms of tuberculosis, the chances that an exposed person will get infected depend on whether the individual and the bacteria share a hometown, according to a new study comparing how different strains move through mixed populations in cosmopolitan cities.

2 Aug 2024

The Role of Chemical Proteomics in Understanding Small Molecule-Protein Interactions

The various chemical proteomics methods with relevant examples.

31 Jul 2024

IL-22BP Protein's Influence on Gut Microbiota and Infection Response Revealed

A study reported in Proceedings of the National Academy of Sciences (PNAS) shows how the presence of a specific protein called IL-22BP affects the composition of the gut microbiota and the body's response to bacterial infection.

30 Jul 2024

CRISPR-Cas Vs. Anti-CRISPR Proteins: The Battle Over Antibiotic Resistance In Bacteria

The relationship between antibiotic resistance in bacteria and the interactions between the CRISPR-Cas system and anti-CRISPR proteins.

30 Jul 2024

Injectable Therapy Using 'Dancing Molecules' Promises New Hope for Cartilage Repair

In November 2021, Northwestern University researchers introduced an injectable new therapy, which harnessed fast-moving "dancing molecules," to repair tissues and reverse paralysis after severe spinal cord injuries.

29 Jul 2024

Advancing Cancer Drug Discovery: The Enduring Value of Phenotypic Screening

The niche areas in which phenotypic screening continues to be advantageous over the targeted approach, and the recent advances in phenotypic screening technology that have increased their efficiency.

26 Jul 2024

Antisense Therapy Shows Promise Against Parkinson's

Parkinson's disease (PD), as well as many other neurodegenerative disorders, has shown a link between the abnormal aggregation of a protein called α-synuclein (aSyn) and neuronal death. These aggregates, known as Lewy bodies and Lewy neurites depending on their subcellular localization, can spread by continuously causing normal endogenous aSyn to misfold.

26 Jul 2024

New Assay Fast-Tracks Virucidal Testing

An innovative technique that can quickly ascertain whether a virus is contagious or not has the potential to completely transform how humans respond to pandemics in the future.

24 Jul 2024

Ginseng Genome Map Unlocks New Possibilities for Medicinal Applications

A landmark study has successfully decoded the complete ginseng genome, unveiling the genetic mechanisms that govern saponin biosynthesis. This detailed genetic map illuminates the evolutionary and metabolic pathways of Panax ginseng, a staple in traditional medicine.

19 Jul 2024

New Approach to Finding Antibiotic Alternatives Using Bacterial Data

Researchers have devised an approach for identifying novel antimicrobial drugs with clinical potential using bacterial databases, offering insights into finding alternatives to existing antibiotics.

17 Jul 2024

Unveiling IRF1's Influence on Cancer Progression and Treatment Using Histology and Flow Cytometry

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have discovered new information regarding the function of a protein known as interferon regulatory factor (IRF1) in the course of cancer and how it responds to treatment. This information may help increase the efficacy of cancer immunotherapy.

16 Jul 2024

Neuregulin 3 Gene Variant Linked to Gabapentin Effectiveness in Chronic Pelvic Pain

Women who carry a particular form of a pain gene are more likely to respond well to a common medication used to treat long-term discomfort, research shows.