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Persistent tumor mutation load may help predict outcome of novel immunotherapies

Cancer experts have tried, sometimes unsuccessfully, to use the total number of mutations in a tumor, called the tumor mutation burden (TMB), to predict a patient's response to immunotherapy.

27 Jan 2023

New study figures out which patients will react to immunotherapy

According to a new study, patients with head and neck cancer who have more chromosome 9 genetic material in their cancer cells survive three times longer after accepting immunotherapy than patients who have less of it.

From New York University (NYU) 15 Nov 2022

Different cancers carry distinctive genetic signatures

After analyzing data from a public repository, CD4-T, CD8-T cells, and Treg cells, a team of researchers led by bioinformatics Mabel Vidal from the University of Concepcion and working with researchers from MELISA Institute and other academic institutions discovered a distinctive genetic signature among subsets of infiltrating T cells of various types of cancer.

4 Nov 2022

Common genetic variants associated with beat synchronization identified

The first large-scale genomic study of musicality revealed 69 genetic variations linked with beat synchronization, which denotes the ability to move in time with the beat of the music.

From Vanderbilt University 20 Sep 2022

Researchers develop targeted immunotherapy to destroy tumor cells

A minimally invasive technique was created and improved by scientists at Terasaki Institute for Biomedical Innovation (TIBI) to develop immunotherapeutic cancer treatments.

3 Aug 2022

Study shows how mitochondrial RNA changes enhance invasive growth of cancer cells

The energy centers of cells and mitochondria have their own genetic material and RNA molecules.

1 Jul 2022

Novel nanoparticle therapeutic shows potential for treating human cancers

Researchers from Wake Forest University School of Medicine have discovered a possible new approach to treating solid tumors through the creation of a novel nanoparticle. Solid tumors are found in cancers such as breast, head and neck, and colon cancer.

15 Jun 2022

Computational approach could enable large-scale analyses of tumor-specific total mRNA levels from patient samples

Researchers at The University of Texas MD Anderson Cancer Center have developed a new approach to quantify tumor-specific total mRNA levels from patient tumor samples, which contain both cancer and non-cancer cells.

14 Jun 2022

Study shows the role of mucosal-associated invariant T cell in mucosal melanomas patients

Many cancer patients have benefited from the development of anti-cancer immunotherapy drugs known as immune checkpoint inhibitors, but patients with mucosal melanomas—melanomas that occur in the mucous membranes of the head, neck, eyes, respiratory system, and genitourinary region rather than on the skin—are highly resistive to immune checkpoint inhibitors for reasons researchers do not fully understand.

29 Apr 2022

Scientists discover a special cell in salivary glands that is likely crucial for oral health

Scientists at Scripps Research and the National Institute of Dental and Craniofacial Research have discovered a special type of cell that resides in salivary glands and is likely crucial for oral health.

13 Apr 2022

Specific gene variant linked with poor response to sublingual immunotherapy for allergies

Although sublingual immunotherapy (SLIT) has become an effective treatment option for many allergies, about 20-30% of patients don’t respond to SLIT for Japanese cedar pollinosis–a highly common disease.

8 Mar 2022

Mortality of newborns on ECMO linked with red blood cell transfusion volume

Newborns in respiratory failure who require the life-sustaining support of ECMO also require transfusion of red blood cells. But a new study indicates that the higher volume of these oxygen-carrying blood cells the babies receive, the higher their mortality rate.

15 Feb 2022

Neck News and Research

Persistent tumor mutation load may help predict outcome of novel immunotherapies

New study figures out which patients will react to immunotherapy

Different cancers carry distinctive genetic signatures

Common genetic variants associated with beat synchronization identified

Researchers develop targeted immunotherapy to destroy tumor cells

Study shows how mitochondrial RNA changes enhance invasive growth of cancer cells

Novel nanoparticle therapeutic shows potential for treating human cancers

Computational approach could enable large-scale analyses of tumor-specific total mRNA levels from patient samples

Study shows the role of mucosal-associated invariant T cell in mucosal melanomas patients

Scientists discover a special cell in salivary glands that is likely crucial for oral health

Specific gene variant linked with poor response to sublingual immunotherapy for allergies

Mortality of newborns on ECMO linked with red blood cell transfusion volume

Scientists find how cells remain dormant for years before awakening to create metastatic cancer

Novel therapeutic approach forces cancer cells to dormancy, prevents metastasis

Researchers discover molecular mechanism that explains why moles become melanomas

Genomic changes in advanced tumors reveal interactions with treatment

Brown fat protects against secondary obesity-related diseases, says study

Research uncovers key component of cellular malfunction that contributes to tumor growth

SARS-CoV-2 virus may be able to infect the inner ear, study shows

Researchers identify the mechanism leading to deafness in Norrie disease

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