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Scientists find how cells remain dormant for years before awakening to create metastatic cancer

Mount Sinai researchers have solved a major mystery in cancer research: How cancer cells remain dormant for years after they leave a tumor and travel to other parts of the body, before awakening to create metastatic cancer.

14 Dec 2021

Research describes dynamic genomic landscape of tumor heterogeneity in hepatocellular carcinoma

Clinician scientists and scientists from the National Cancer Centre Singapore and A*STAR's Genome Institute of Singapore, in collaboration with Singapore General Hospital, the National University Health System, Duke-NUS Medical School, Nanyang Technological University, and collaborators from China, Malaysia, Thailand and the Philippines, have described a dynamic genomic landscape of tumour heterogeneity in hepatocellular carcinoma (HCC).

13 Dec 2021

New classification method divides breast cancers into 12 distinct biological groups

Researchers at UNC Lineberger Comprehensive Cancer Center have taken a major step forward in melding two key methods for studying breast cancer: one by genetic analysis and the second by looking at the architecture of cells, or their pathology.

9 Dec 2021

Highly optimized X-ray process delivers high-resolution 3D images of cells

Viral pathogens such as the SARS-CoV-2 coronavirus alter the interior structure of the cells they infect.

8 Dec 2021

Experts create world’s first single-cell atlas of human and porcine eyes

Researchers recently constructed the first single-cell atlas of the human and porcine eyes.

8 Dec 2021

Experts identify first non-coding RNA that controls chromosome loop formation

Recent research carried out by scientists from Massachusetts General Hospital (MGH) reveals that a significant player in the healthy development of female embryos also performs a vital role in controlling the behavior of chromosome loops and gene expression in both sexes.

7 Dec 2021

Research team grows mini-stomach across varying stages of development

A group of researchers led from Great Ormond Street Hospital (GOSH) hinged on recent progress to culture “mini-organs” in a lab, called organoids.

From University College London 7 Dec 2021

Long-term exposure to particulate matter associated with hypertension

According to the WHO, air pollution is the greatest health risk worldwide, accounting for more than 4.2 million deaths annually.

6 Dec 2021

Daytime eating maintains circadian alignment, prevents glucose intolerance despite mistimed sleep

What are the effects of eating during the nighttime instead of the daytime? New research, focused on a simulation of night shift work, may hold implications for people eating at atypical times -; like those experiencing jet lag, circadian rhythm sleep disorders, or who tend to sleep late during the weekends.

6 Dec 2021

Researchers identify a new approach to triggering differentiation in acute myeloid leukemia

In the late 1980s, scientists developed a revolutionary approach to treating acute myeloid leukemia (AML), a type of blood cancer. Called differentiation therapy, it amounted to a bona fide cure for many patients.

2 Dec 2021

Next-generation sequencing for minimal residual disease proven more sensitive than flow cytometry

In pediatric and young adult patients with acute lymphoblastic leukemia (ALL) treated with tisagenlecleucel (Kymriah), DNA sequencing-based detection of residual disease between three and 12 months accurately identified all patients who would eventually relapse, while other methods were less predictive.

2 Dec 2021

Novel technique precisely corrects DNA errors in cultured patient cells

Scientists recently created a technique to accurately and quickly correct genetic alterations in the cultivated patient cells.

2 Dec 2021

Cytomegalovirus accelerates the decline of the immune system regardless of age

Scientists from the University of Córdoba have been investigating the changes that occur in the T lymphocytes of the immune system with increasing age.

2 Dec 2021

Researchers successfully generated Leydig cells from human iPS cells

Scientists recently succeeded in creating Leydig cells from human induced pluripotent stem (iPS) cells.

2 Dec 2021

Lung cancer: Cholesterol metabolism of tumor-associated macrophages found to be severely compromised

Significant changes in lipid metabolism are known to occur in cells associated with non-small-cell lung carcinoma – the most common form of lung cancer.

1 Dec 2021

Experts investigate adaptations that confer antibiotic resistance to pathogens

Researchers anticipate that without intervention, the issue of multidrug-resistant bacterial infections could become catastrophic by 2050.

25 Nov 2021

Researchers discover molecular mechanism that explains why moles become melanomas

Moles and melanomas are both skin tumors that come from the same cell called melanocytes. The difference is that moles are usually harmless, while melanomas are cancerous and often deadly without treatment.

24 Nov 2021

New details about Shigella's translocon may help develop effective strategy to block infection

Shigella, a bacterial pathogen that causes dysentery and is the leading cause of childhood diarrheal diseases, inserts a pore called a translocon into an infected person's intestinal cells and then injects bacterial proteins into the cells.

24 Nov 2021

Deep learning can generate real insights into how proteins interact

Scientist are now combining recent advances in evolutionary analysis and deep learning to build three-dimensional models of how most proteins in eukaryotes interact.

23 Nov 2021

Cancer cells disarm immune cells by hijacking mitochondria, says research

Researchers utilized the power of nanotechnology to identify a novel means that cancer cells use to disarm their would-be cellular attackers.

19 Nov 2021

Hospital News and Research

Scientists find how cells remain dormant for years before awakening to create metastatic cancer

Research describes dynamic genomic landscape of tumor heterogeneity in hepatocellular carcinoma

New classification method divides breast cancers into 12 distinct biological groups

Highly optimized X-ray process delivers high-resolution 3D images of cells

Experts create world’s first single-cell atlas of human and porcine eyes

Experts identify first non-coding RNA that controls chromosome loop formation

Research team grows mini-stomach across varying stages of development

Long-term exposure to particulate matter associated with hypertension

Daytime eating maintains circadian alignment, prevents glucose intolerance despite mistimed sleep

Researchers identify a new approach to triggering differentiation in acute myeloid leukemia

Next-generation sequencing for minimal residual disease proven more sensitive than flow cytometry

Novel technique precisely corrects DNA errors in cultured patient cells

Cytomegalovirus accelerates the decline of the immune system regardless of age

Researchers successfully generated Leydig cells from human iPS cells

Lung cancer: Cholesterol metabolism of tumor-associated macrophages found to be severely compromised

Experts investigate adaptations that confer antibiotic resistance to pathogens

Researchers discover molecular mechanism that explains why moles become melanomas

New details about Shigella's translocon may help develop effective strategy to block infection

Deep learning can generate real insights into how proteins interact

Cancer cells disarm immune cells by hijacking mitochondria, says research

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