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Non-coding RNA molecule helps lung cancer cells evade immune cells

Researchers in Spain have identified a non-coding RNA molecule that helps lung cancer cells proliferate and avoid being killed by the body's immune cells.

28 Aug 2020

Novel computational approach helps find genetic causes of severe childhood brain disorders

A team of researchers at Children's Hospital of Philadelphia affiliated with the CHOP Epilepsy Neurogenetics Initiative (ENGIN) have combined clinical information with large-scale genomic data to successfully link characteristic presentations of childhood epilepsies with specific genetic variants.

27 Aug 2020

Protein structural study may lead to more improved research on disease development

Researchers had identified an actin cytoskeketal nucleator, called Arp2/3 complex, more than 20 years ago.

26 Aug 2020

Study uncovers how the immune system generates effective antibodies

An in-depth Garvan study of how the immune system generates effective antibodies provides new insights for vaccine design.

25 Aug 2020

Each person's gut has a unique viral 'fingerprint'

Each person's gut virus composition is as unique as a fingerprint, according to the first study to assemble a comprehensive database of viral populations in the human digestive system.

25 Aug 2020

Researchers discover antibodies that may provide effective immunity against SARS-CoV-2

A new study by researchers at MassBiologics of UMass Medical School published in Nature Communications suggests that COVID specific IgA monoclonal antibodies may provide effective immunity in the respiratory system against the novel coronavirus - a potentially critical feature of an effective vaccine.

25 Aug 2020

Researchers add a component to make cancer vaccine more effective

Jefferson researchers developing a cancer vaccine to prevent recurrences of gastric, pancreatic, esophageal and colon cancers have added a component that would make the vaccine more effective.

25 Aug 2020

Lipid-based nanoparticles can help treat genetic disorders

Introducing genetic material into the body to treat diseases can work, but making sure that those materials are safely sent to the right location is complicated.

24 Aug 2020

New bioluminescent reporter tracks DNA double stranded break repair in cells

A new bioluminescent reporter that tracks DNA double stranded break (DSB) repair in cells has been developed by researchers from Massachusetts General Hospital (MGH) and the Academia Sinica in Taiwan.

24 Aug 2020

Eliminating tumors with engineered ‘off-the-shelf’ therapeutic T cells

Personalized cancer treatments are no longer just options of the future. In the past few years, researchers have made significant progress in 'teaching' the body's immune T cells to recognize and kill specific cancer cells, and human clinical trials have shown that this approach can successfully eliminate tumors

21 Aug 2020

Genetic background influences cancer risk in individuals with single-gene variants

Life can change dramatically when someone learns they are genetically predisposed to a disease, such as a condition called familial hypercholesterolemia, where a mutated gene can lead to elevated cholesterol and increased risk for a premature heart attack.

21 Aug 2020

Study offers promising data for improved treatments for cardiac disease

A group of researchers have recently published an article that provides promising data for enhanced therapeutic treatments for cardiac disease.

20 Aug 2020

Study reveals a mechanism for lower-quality immune response in patients with severe COVID-19

The release of massive amounts of proteins called cytokines can lead to some of the most severe symptoms of COVID-19.

From Harvard Medical School 20 Aug 2020

Shielded stem cells can improve heart healing

Ghanta, R.K., et al. (2020) Immune-modulatory alginate protects mesenchymal stem cells for sustained delivery of reparative factors to ischemic myocardium. Biomaterials Science. doi.org/10.1039/D0BM00855A.

19 Aug 2020

Surface structure of SARS-CoV-2 virus offers insights for development of therapeutics

At the start of a COVID-19 infection, the coronavirus SARS-CoV-2 docks onto human cells using the spike-like proteins on its surface. The spike protein is at the centre of vaccine development because it triggers an immune response in humans.

19 Aug 2020

Scientists identify complex enzyme that protects cells from constant DNA damage

A team of researchers have revealed the mechanism and 3D structure of a complex enzyme that guards cells against persistent DNA damage.

19 Aug 2020

SIDT1 in the mammalian stomach mediates absorption of dietary miRNAs

In a new study published in Cell Research, Chen-Yu Zhang's group at Nanjing University School of Life Sciences, China, reports that SIDT1 in the mammalian stomach mediates host uptake of dietary and orally administered microRNAs (miRNAs), thus exerting biological functions in the host.

18 Aug 2020

Detection of cancer using different kind of liquid biopsy

Because cancer is easier to successfully treat when it's caught early, a major goal in cancer research is to develop new ways to find tumors at early stages, before they start to spread. One approach that's being studied are liquid biopsies.

14 Aug 2020

Combination regimen improves overall survival in acute myeloid leukemia patients

A combination regimen of venetoclax and azacitidine was safe and improved overall survival (OS) over azacitidine alone in certain patients with acute myeloid leukemia (AML), according to the Phase III VIALE-A trial led by The University of Texas MD Anderson Cancer Center.

13 Aug 2020

Study reveals key biochemical processes that advance understanding of colorectal cancer

A new insight into cell signals that control cancer growth and migration could help in the search for effective anti-cancer drugs. A McGill-led study reveals key biochemical processes that advance our understanding of colorectal cancer, the third most common cancer among Canadians.

13 Aug 2020

therapeutics News and Research

Non-coding RNA molecule helps lung cancer cells evade immune cells

Novel computational approach helps find genetic causes of severe childhood brain disorders

Protein structural study may lead to more improved research on disease development

Study uncovers how the immune system generates effective antibodies

Each person's gut has a unique viral 'fingerprint'

Researchers discover antibodies that may provide effective immunity against SARS-CoV-2

Researchers add a component to make cancer vaccine more effective

Lipid-based nanoparticles can help treat genetic disorders

New bioluminescent reporter tracks DNA double stranded break repair in cells

Eliminating tumors with engineered ‘off-the-shelf’ therapeutic T cells

Genetic background influences cancer risk in individuals with single-gene variants

Study offers promising data for improved treatments for cardiac disease

Study reveals a mechanism for lower-quality immune response in patients with severe COVID-19

Shielded stem cells can improve heart healing

Surface structure of SARS-CoV-2 virus offers insights for development of therapeutics

Scientists identify complex enzyme that protects cells from constant DNA damage

SIDT1 in the mammalian stomach mediates absorption of dietary miRNAs

Detection of cancer using different kind of liquid biopsy

Combination regimen improves overall survival in acute myeloid leukemia patients

Study reveals key biochemical processes that advance understanding of colorectal cancer

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