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Study shows link between metabolic and cell division mechanisms

Several biological processes are subject to rhythmic variations. Popular examples of this include the supposed circadian rhythm.

17 Feb 2021

Oncotarget review highlights molecular connections between cancer stem cells and macrophages

Oncotarget published "Cancer stem cells and macrophages: molecular connections and future perspectives against cancer" which reported that Cancer stem cells have been considered the key drivers of cancer initiation and progression due to their unlimited self-renewal capacity and their ability to induce tumor formation.

17 Feb 2021

Study suggests a way to improve immunotherapy by altering immune cells’ access to sugar

Cancer cells and immune cells share something in common: They both love sugar. Sugar is an important nutrient. All cells use sugar as a vital source of energy and building blocks. For immune cells, gobbling up sugar is a good thing, since it means getting enough nutrients to grow and divide for stronger immune responses. But cancer cells use sugar for more nefarious ends.

17 Feb 2021

Gut microbiome alterations help melanoma patients to respond to immunotherapy

Statistical modeling developed by Oregon State University researchers has confirmed that changes to melanoma patients' gut microbiome led them to respond to a type of treatment capable of providing long-term benefit.

17 Feb 2021

Tumor microenvironment could improve cancer immunotherapy

A study has revealed how chemicals surrounding tumors, the tumor microenvironment, undermine the immune system and allow cancer to resist attack.

From University of Pittsburgh 16 Feb 2021

New understanding of tumor microenvironment could help enhance immunotherapy

A paper published today in Nature shows how chemicals in the areas surrounding tumors--known as the tumor microenvironment--subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy.

From University of Pittsburgh 16 Feb 2021

Gene-based blood test may predict treatment success in people with metastatic melanoma

A test that monitors blood levels of DNA fragments released by dying tumor cells may serve as an accurate early indicator of treatment success in people in late stages of one of the most aggressive forms of skin cancer, a new study finds.

From New York University (NYU) 15 Feb 2021

Researchers use mouse models to explain how cancer cells spread

Most tumors consist of a heterogenous mix of cells. Genetic mutations found only in some of these cells are known to aid with the spread and progression of cancer.

15 Feb 2021

Study reveals a new role of SRC-3 protein in various cancers

New research has revealed a new role of the steroid receptor coactivator 3, also called SRC-3/NCOA3.

15 Feb 2021

Genomic test helps identify prostate cancer patients who may benefit from hormone therapy

A commercially available genomic test may help oncologists better determine which patients with recurrent prostate cancer may benefit from hormone therapy, according to new research from the Johns Hopkins Kimmel Cancer Center and 15 other medical centers.

12 Feb 2021

N-terminal acetylation shields proteins from degradation and inhibits programmed cell death

A new study shows that proteins called IAPs, which can trigger programmed cell death, are inhibited by a specific chemical modification, and reveals that they play a wider role in protein quality control than previously assumed.

11 Feb 2021

Inherited genetic variation plays a role in how patients respond to cancer immunotherapy

For all their importance as a breakthrough treatment, the cancer immunotherapies known as checkpoint inhibitors still only benefit a small minority of patients, perhaps 15 percent across different types of cancer. Moreover, doctors cannot accurately predict which of their patients will respond.

11 Feb 2021

Scientists use new approach to avert drug resistance in glioblastomas

In far too many cases over the years, scientists have discovered promising new cancer treatments, only to report later that the tumor cells found ways to become resistant. These disappointing results have made overcoming drug resistance a major goal in cancer research.

11 Feb 2021

Researchers identify tumor suppressor gene involved in stress response

Even the larvae of the Drosophila fly contain adult progenitor cells. And these cells are the only ones that are preserved throughout the growth and are responsible for the development of adult tissues and organs.

11 Feb 2021

Mast Cells: High-speed messengers of the immune defense

In order to fight pathogens, mast cells regulate inflammatory reactions of the immune system.

10 Feb 2021

New platform may accelerate genomic medicine research, drug therapies

A research team, headed by Cleveland Clinic, has designed a novel personalized genomic medicine platform that would help speed up genomic medicine studies as well as genome-informed drug discovery. The results of the new study have been recently published in the Genome Biology journal.

9 Feb 2021

Blocking autophagy could help treat certain cancers

Recycling cans and bottles is a good practice. It helps keep the planet clean. The same is true for recycling within cells in the body. Each cell has a way of cleaning out waste in order to regenerate newer, healthier cells. This "cell recycling" is called autophagy.

9 Feb 2021

AI analyzes tissue scans to identify cancer patients at risk of hyperprogressive disease

Researchers at Case Western Reserve University, using artificial intelligence (AI) to analyze simple tissue scans, say they have discovered biomarkers that could tell doctors which lung cancer patients might actually get worse from immunotherapy.

5 Feb 2021

Fecal microbiota transplant helps cancer patients respond to immunotherapy

For patients with cancers that do not respond to immunotherapy drugs, adjusting the composition of microorganisms in the intestines--known as the gut microbiome--through the use of a stool, or fecal, transplants may help some of these individuals respond to the immunotherapy drugs, a new study suggests.

From National Cancer Institute (NCI) 5 Feb 2021

Researchers explore the regulatory role of protein in human health and disease

Researchers from the University of Virginia, Lehigh University and the Massachusetts Institute of Technology are pooling their respective labs' expertise to unlock the mysteries of a protein that plays a critical regulatory role in human health and disease.

5 Feb 2021

Tumor News and Research

Study shows link between metabolic and cell division mechanisms

Oncotarget review highlights molecular connections between cancer stem cells and macrophages

Study suggests a way to improve immunotherapy by altering immune cells’ access to sugar

Gut microbiome alterations help melanoma patients to respond to immunotherapy

Tumor microenvironment could improve cancer immunotherapy

New understanding of tumor microenvironment could help enhance immunotherapy

Gene-based blood test may predict treatment success in people with metastatic melanoma

Researchers use mouse models to explain how cancer cells spread

Study reveals a new role of SRC-3 protein in various cancers

Genomic test helps identify prostate cancer patients who may benefit from hormone therapy

N-terminal acetylation shields proteins from degradation and inhibits programmed cell death

Inherited genetic variation plays a role in how patients respond to cancer immunotherapy

Scientists use new approach to avert drug resistance in glioblastomas

Researchers identify tumor suppressor gene involved in stress response

Mast Cells: High-speed messengers of the immune defense

New platform may accelerate genomic medicine research, drug therapies

Blocking autophagy could help treat certain cancers

AI analyzes tissue scans to identify cancer patients at risk of hyperprogressive disease

Fecal microbiota transplant helps cancer patients respond to immunotherapy

Researchers explore the regulatory role of protein in human health and disease

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