Central Nervous System News and Research

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Mitochondria Transfer From Astrocytes Enhances Tumorigenesis in Glioblastoma

Glioblastoma cancer cells use mitochondria from the central nervous system to grow and form more aggressive tumors, according to new Cleveland Clinic-led findings published in Nature Cancer.

12 May 2023

Experimental Model Sheds Light on Key Cellular Processes Involved in Embryogenesis

Many birth defects and spontaneous abortions occur during the embryonic development stage known as neurulation, yet we have very little insight into how this critical developmental process unfolds in humans.

9 May 2023

A Study on Gene Silencing Through a Recent Trial

Dr Catherine Mummery, a consultant neurologist at UCL Queen Square Institute of Neurology & the National Hospital for Neurology and Neurosurgery, has led a trial. The trial signifies for the first time that a “gene silencing” method has been taken in Alzheimer’s and dementia disease.

From University College London 27 Apr 2023

Mathematical Mechanism Behind the Rugged Structures at Cell Boundaries

The mathematical and biological mechanisms underlying the rugged structures at cell boundaries present in tissues like the kidneys and nasal glands have been discovered.

26 Apr 2023

Molecular Mechanisms That Maintain the Tissue Specificity of PKMzeta

The protein PKMzeta has been strongly associated with long-term memory formation.

19 Apr 2023

New Peptide Blocks a Hyperactive Brain Enzyme Involved in Neurodegeneration

MIT neuroscientists have found a way to reverse neurodegeneration and other symptoms of Alzheimer's disease by interfering with an enzyme that is typically overactive in the brains of Alzheimer's patients.

17 Apr 2023

Retinal Microvasculature may be a Potential Biological Indicator for Predicting Acute Mountain Sickness

This study is led by Dr.Ningli Wang and Dr.Yuan Xie (Beijing Tongren Hospital, Capital Medical University), they provide evidence that retinal microvasculature is a potential biomarker for cerebral microvasculature changes and acute mountain sickness(AMS) development during risk assessment of individuals at high altitudes.

10 Apr 2023

Astrocytes in the Brain may Play a Key Role in Regulating Information

Long thought of as "brain glue," the star-shaped cells called astrocytes-;members of a family of cells found in the central nervous system called glial that help regulate blood flow, synaptic activity, keep neurons healthy, and play an important role in breathing.

3 Apr 2023

Common Epstein-Barr virus may be a trigger for multiple sclerosis

In 1868, French physician Jean-Martin Charcot, known as the founder of modern neurology, defined a disease entity in which multiple plaques formed in the brain and spinal cord, with varying physical symptoms, called Sclérose en plaques, or in English as multiple sclerosis (MS).

24 Mar 2023

Wearable microscopes produce real-time images of mouse spinal cord activity

The spinal cord acts as a messenger, carrying signals between the brain and body to regulate everything from breathing to movement.

23 Mar 2023

Study reveals the cellular composition and circuit organization of the locus coeruleus

A small nucleus in the brainstem called locus coeruleus (literally the "blue spot,") is the primary source of a major neuromodulator, norepinephrine (NE), an important mediator of the 'fight or flight' response in animals. However, very little is known about the local connections of this small albeit critically important group of neurons.

16 Mar 2023

Novel platform identifies genes that control biologic processes

Inflammatory neurological diseases, such as multiple sclerosis (MS), can arise when cell-to-cell communication between cells in the central nervous system (CNS) goes awry. But exactly how this cellular crosstalk leads to the molecular changes that drive disease remain unknown.

13 Mar 2023

Researchers find methods to awaken and revive neural stem cells

Some areas of the adult brain contain quiescent, or dormant, neural stem cells that can potentially be reactivated to form new neurons. However, the transition from quiescence to proliferation is still poorly understood. A team led by scientists from the Universities of Geneva (UNIGE) and Lausanne (UNIL) has discovered the importance of cell metabolism in this process and identified how to wake up these neural stem cells and reactivate them. Biologists succeeded in increasing the number of new neurons in the brain of adult and even elderly mice. These results, promising for the treatment of neurodegenerative diseases, are to be discovered in the journal Science Advances.

2 Mar 2023

Insilico Medicine: IND application for first generative AI-designed drug for COVID-19 approved

Insilico Medicine, a clinical-stage biotech company powered by generative AI, today announces that China National Medical Products Administration (NMPA) has approved the Investigational New Drug (IND) application for ISM3312, an orally available 3CLpro inhibitor generated and designed with the support of Insilico's proprietary generative chemistry platform Chemistry42 for the treatment of COVID-19.

24 Feb 2023

Realistic model explores new treatments for brain tumors

Until now, the use of models to study the barrier that differentiates the circulatory and nervous systems has been either limited or extremely complex. ETH Zurich researchers have created a more accurate model that can also be used to effectively investigate new treatments for brain tumors.

21 Feb 2023

Study reveals important role of Secretin receptor in regulating drinking behavior under thirst

Animals instinctively find and consume water when feeling thirsty in order to restore body fluid osmolality and plasma volume to their set points.

15 Feb 2023

Study charts seasonal and circadian genetic variation across the human body

The daily rotation of Earth and its yearly voyage around the Sun marks the natural rhythm of life on the planet.

14 Feb 2023

Promotional spending share allocated to consumer advertising higher for drugs with low added benefit

A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health found that the share of promotional spending allocated to consumer advertising was on average 14.3 percentage points higher for drugs with low added benefit compared to drugs with high added benefit.

8 Feb 2023

UNC research describes another layer to the challenge of HIV latency

When people living with HIV take antiviral therapy (ART), their viral loads are driven so low that a standard blood test cannot detect the virus.

1 Feb 2023

Flexible copper sensor detects heavy metals in sweat

Heavy metals such as lead and cadmium are present in batteries, cosmetics, food and other things that are part of everyday life.

24 Jan 2023