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New research center brings advancements in genomic medicine to admixed individuals

One way to make health care more personalized is to use a person's DNA sequence -; or genome -; to predict their risk of disease. But as the field of precision medicine grows, so have concerns that we may be leaving a large fraction of Americans out.

From UC San Diego 13 Oct 2021

Study unravels factors involved in risiRNA generation

A team of scientists disclosed the nucleolar RNA interference based on Caenorhabditis elegans (C. elegans) as a model organism.

1 Oct 2021

Tumor suppressor protein binding to RNA also binds DNA, says study

Scientists from the Medical University of South Carolina earlier displayed how hnRNP E1 attaches to metastatic-linked RNAs to prevent their translation.

27 Sep 2021

Genetic and epigenetic origin of pediatric liver cancer uncovered

Researchers at Hiroshima University have analyzed the molecular findings of almost 160 pediatric liver cancer cases and discovered molecular markers that should help to understand and treat the considerable variation in prognoses.

22 Sep 2021

Scientists develop a technique for reconstructing whole genomes on a personal computer

Scientists at the Massachusetts Institute of Technology and the Institut Pasteur in France have developed a technique for reconstructing whole genomes, including the human genome, on a personal computer.

From Massachusetts Institute of Technology (MIT) 15 Sep 2021

Researchers discover nucleotide sequences characteristic of microRNA isoforms

Researchers from HSE University have discovered nucleotide sequences characteristic of microRNA isoforms (microRNAs with errors).

22 Jul 2021

Researchers identify gene responsible for vicine-convicine content in faba beans

Faba beans are exceptional sources of food protein; however, around 4 % of the world’s population is affected by favism.

12 Jul 2021

Protein's 'silent code' influences cell movement

The protein actin is ubiquitous and essential for life. In mammals, every cell expresses two of its forms, beta-actin and gamma-nonmuscle-actin. Despite having distinct roles, the two forms are nearly identical, sharing 99% of their amino acid sequence.

8 Jul 2021

Study identifies the gene responsible for toxic vicine and convicine production in faba beans

Faba beans have been a good source of protein. A team of experts has now found the gene that causes the toxic vicine and convicine to be produced.

7 Jul 2021

Worm cells sense metabolism changes to stimulate their defense against pathogens

Microbial infections form part of the wider repercussions of the COVID-19 pandemic, and researchers are focusing more on such infections.

1 Jun 2021

Researchers prove that drugs designed for bacteria have the potential to act on human cells

Antibiotics used to treat common bacterial infections may potentially be used to treat human illnesses such as cancer, at least theoretically.

27 May 2021

Refreshers develop new DNA sequencing method

An international research team headed by Michal Hocek of the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) and Charles University and Ciara K. O'Sullivan of Universitat Rovira i Virgili (URV) in Spain have developed a novel method for labeling DNA, which in the future can be used for sequencing DNA by means of electrochemical detection.

18 May 2021

“Expansion Hunter” approach can detect DNA errors

Researchers from Radboud University Medical Center have successfully detected hidden genetic defects by using an existing technique on existing datasets. The team demonstrated that the “Expansion Hunter” approach can detect DNA errors that cause repeat expansion diseases, like ataxia—a movement disorder.

16 Apr 2021

Inhibiting a specific protein could increase tumor sensitivity to PARP inhibitors

Researchers at the Francis Crick Institute have found that blocking a specific protein could increase tumor sensitivity to treatment with PARP inhibitors. Their work published in Science , suggests combining treatments could lead to improved therapy for patients with inheritable breast cancers.

9 Apr 2021

Study demonstrates how DNA-like molecules could have joined to form the origin of life

Nagoya University scientists in Japan have demonstrated how DNA-like molecules could have come together as a precursor to the origins of life.

7 Apr 2021

Researchers take a key step toward new drugs and vaccines for combating COVID-19

Scientists have achieved a huge step toward new vaccines and drugs for fighting against COVID-19.

6 Apr 2021

Supercomputer simulations help uncover the mechanism for HIV replication

Viruses lurk in the grey area between the living and the nonliving, according to scientists. Like living things, they replicate but they don't do it on their own. The HIV-1 virus, like all viruses, needs to hijack a host cell through infection in order to make copies of itself.

1 Apr 2021

New highly sensitive RNA detection method advances in situ transcriptomics

Human cells typically transcribe half of their roughly 20,000 genes into RNA molecules at any given time. Just like with proteins, the function of those RNA species not only relies on their abundance but also their precise localization within the 3D space of each cell.

18 Mar 2021

ADAR1 protein offers a potential therapeutic target for cancer

A research team has discovered a new role of ADAR1 and found that the ADAR1p110 isoform controls genome stability at the ends of chromosomes.

15 Mar 2021

Genomics study examines the impact of COVID-19 on care homes

Care homes are at high risk of experiencing outbreaks of COVID-19, the disease caused by SARS-CoV-2. Older people and those affected by heart disease, respiratory disease and type 2 diabetes - all of which increase with age - are at greatest risk of severe disease and even death, making the care home population especially vulnerable.

4 Mar 2021