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New therapeutic approaches to treat autoimmune diseases using a metabolite

Researchers have revealed the modulatory effect of the anti-inflammatory metabolite itaconate on T helper and T regulatory cells, which may lead to new therapeutic approaches to treating some autoimmune diseases.

16 Mar 2023

Understanding the factors that impact CRISPRa efficiency

Investigators, from the Wellcome Sanger Institute and partners, utilized human stem cells and neurons to explore what attributes impact how well CRISPR activation works for different sets of genes.

14 Mar 2023

New class of oral drugs inhibits a diverse range of SARS-CoV-2 strains

The constant evolution of new COVID-19 variants makes it critical for clinicians to have multiple therapies in their arsenal for treating drug-resistant infections. Researchers have now discovered that a new class of oral drugs that acts directly on human cells can inhibit a diverse range of pathogenic SARS-CoV-2 strains.

13 Mar 2023

DNA methylation for precise gene expression regulation

If the genome is viewed as a guidebook for how a cell should operate, then annotations, highlights, and bookmarks are included on every page.

21 Feb 2023

UVA researchers discover a key trigger for common liver disease

University of Virginia School of Medicine researchers have discovered a key trigger for non-alcoholic fatty liver disease, a mysterious condition that causes fat to build up in the liver for no clear reason.

10 Feb 2023

Researchers report the genome-wide atlas of chromatin-accessibility during stomatal development

Researchers at Nagoya University in Japan, the University of Texas at Austin, and the University of Washington have elucidated a mechanism that makes tiny plant stem cells destined to give rise to stomata, cellular valves of plants that facilitate global carbon cycles.

9 Feb 2023

A soybean genome in pan-3D

For cis-regulatory elements in the genome to function, which is crucial for gene regulation, a high-order chromatin structure is required. Three-dimensional (3D) genome organization in eukaryotes exhibits a hierarchical structure.

8 Feb 2023

Gaining insights into human disease biology through CRISPR platforms

In this interview, we speak with Laralynne Przybyla about how she is utilizing CRISPR platforms to understand human disease biology in greater detail.

From Society for Laboratory Automation and Screening (SLAS) 7 Feb 2023

“Reference Epigenome” and regulatory mechanisms in wheat embryogenesis

One of the most basic and amazing processes that occur in both plants and animals is embryogenesis. It is incredible that, within a matter of weeks after fertilization, a single mother egg cell can transform into a living thing with a complex body structure.

6 Feb 2023

Novel protein degradation technology provides functional insights into how CTCF regulates transcription

CTCF is a critical protein known to play various roles in key biological processes such as transcription.

30 Jan 2023

Lysis and hypotonic sonication buffers for ChIP assays

Offering complete disruption of cytoplasmic and nuclear membranes, Porvair Sciences Chromatrap® buffer chemistries are optimised for sonication and enzymatic shearing.

From Porvair Sciences Limited 29 Nov 2022

New computational approach enhances the performance of bioinformatics tools

UVA Health researchers have created an innovative tool to assist scientists in distinguishing signals from noise as they investigate the genetic underpinnings of cancer and other disorders.

24 Nov 2022

Statistical methodology uncovers changes in genomic data

A novel statistical technique makes it easier to find biologically significant changes in genomic data that span multiple conditions, like cell types or tissues.

From Penn State University 15 Nov 2022

Researchers uncover a mechanism of flowering plant sperm compaction

Sperm cells have compact bundles of DNA, yet exactly how and why sperm cell nuclei are condensed in flowering plants has been a mystery, until now.

4 Nov 2022

Genome of the earliest common ancestor of all mammals identified

From a platypus to a blue whale, all living mammals today are derived from a single ancestor that existed around 180 million years ago. Although nothing much is known about this species, an international team of experts has now computationally rebuilt how its DNA is organized.

From The University of California, Davis 28 Sep 2022

Understanding the structure of the nucleus inside a cell using mathematics

Recent work shows a novel mathematical approach to start comprehending how a cell’s nucleus is structured.

21 Sep 2022

Unique combination of transcription factors trigger cell regeneration in zebrafish

Scientists at the National Institutes of Health have identified a particular protein network required for cell regeneration to restore hearing in zebrafish.

From National Human Genome Research Institute (NHGRI) 15 Sep 2022

Chromatin displays different dynamics in cells during organ-formation

Recent research from the School of Medicine has illuminated the development of the liver, lungs, and digestive system. This result may have significant ramifications for the comprehension of cancer.

30 Aug 2022

Diseased connective tissue cells alter the physical structure of their genomes

Researchers at Penn Medicine have found that when cells are impacted by the disease, the physical structure of their genome changes.

25 Aug 2022

Study discovers a molecular mechanism that confers special physical properties to chromosomes in dividing human cells

The Gerlich Group at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) has identified a molecular process that gives chromosomes in dividing human cells unique physical characteristics that permit faithful transmission to the progeny.

8 Aug 2022